感染后与非感染后肠易激综合征的多维特点

探讨感染后(PI)与非感染后肠易激综合征(NPI-IBS)的临床,精神心理,组织学特点。取IBS患者和正常人进行问卷调查,了解其多维特点。分别检测肥大细胞的数目。结果显示:(1)PI-IBS与NPI-IBS患者临床、心理特征不同;(2)IBS两组患者肥大细胞的数目无差异,与对照组比较差异明显。因此认为PI-IBS和NPI-IBS有特征差异,对临床治疗有一定指导意义。     

浅述空肠弯曲菌诱发格林-巴利综合征的机制和防控

弯曲菌是全球范围流行的细菌性肠道病原菌之一,对人致病的主要是空肠弯曲菌,HS:19等特定血清型空肠弯曲菌感染是诱发人格林-巴利综合征(GBS)的重要前驱因子。本文浅述了空肠弯曲菌诱发格林-巴利综合征的可能机制,并提出了防控的几点建议。     

Prior sensitivity in theory testing: An apologia for the Bayes factor

A commonly voiced concern with the Bayes factor is that, unlike many other Bayesian and non-Bayesian quantitative measures of model evaluation, it is highly sensitive to the parameter prior. This paper argues that, when dealing with psychological models that are quantitatively instantiated theories, being sensitive to the prior is an attractive feature of a model evaluation measure. This assertion follows from the observation that in psychological models parameters are not completely unknown, but correspond to psychological variables about which theory often exists. This theory can be formally captured in the prior range and prior distribution of the parameters, indicating which parameter values are allowed, likely, unlikely and forbidden. Because the prior is a vehicle for expressing psychological theory, it should, like the model equation, be considered as an integral part of the model. It is argued that the combined practice of building models using informative priors, and evaluating models using prior sensitive measures advances knowledge.     

Fathers' views of the effects on their families of children with Down syndrome

This study examined fathers' views about the effects of children with Down syndrome on themselves and their families. Taped interviews were obtained from 90 fathers of children aged from 7 to 14 years. Qualitative analysis of the interview data revealed 28 categories of comments made by fathers. The most frequent comment, made by 46% of fathers, was about the cheerful personality of their child with Down syndrome. About 42% of fathers talked about the initial trauma they experienced following the diagnosis; 43% of them bemoaned the restrictions imposed on the family, and 30% commented that the child had minimal effects on family life. The greatest concern expressed by fathers was the long-term provision for their children. More fathers commented on the positive effects on their marriage than on negative effects. The results of this study provide a somewhat different view of fathers' experiences to that found in the existing literature.     

The Long-Term Effects of Group-Based Psychological Interventions for Children With Tourette Syndrome: A Randomized Controlled Trial

This randomized controlled trial examined the long-term effects of group-based psychological interventions on measures of tic severity, self-reported quality of life (QOL), and school attendance. Children (n = 28) with Tourette syndrome (TS) were assessed 12 months after completing a course of either group-based Habit Reversal Training (HRT) or Education.Both groups demonstrated long-term improvement in tic severity and QOL, which included significant continued improvement during the follow-up (FU) period. Both groups also showed significant posttreatment improvement in school attendance. Further research is required to explore potential therapeutic mechanisms, independent or mutual, which may underlie long-term symptom improvements.     

Delineation of a spatial working memory profile using a non-verbal eye-tracking paradigm in young children with autism and Williams syndrome

Working memory deficits profoundly inhibit children’s ability to learn. While deficits have been identified in disorders such as autism spectrum disorder (ASD) and Williams syndrome (WS), findings are equivocal, and very little is known about the nature of these deficits early in development. A major barrier to advances in this area is the availability of tasks suitable for young children with neurodevelopmental disorders who experience difficulties with following verbal instructions or who are distressed by formal testing demands. To address these issues, a novel eye-tracking paradigm was designed based on an adaptation of the classic A not B paradigm in order to examine the early foundations of spatial working memory capabilities in 26 developmentally delayed preschool children with ASD, 18 age- and IQ-matched children with WS, and 19 age-matched typically-developing (TD) children. The results revealed evidence that foundational spatial working memory performance in ASD and WS was comparable with that of TD children. Performance was associated with intellectual ability in the ASD and TD groups, but not in the WS group. Performance was not associated with adaptive behavior in any group. These findings are discussed in the context of previous research that has been largely limited to older and substantially less developmentally delayed children with these neurodevelopmental disorders.     

Equivalence‐based instruction to establish a textual activity schedule in an adult with Down syndrome

Transfer of control from picture to text‐based activity schedules has been shown to occur following conditional discrimination training in children with autism. This study extended this research by evaluating if conditional discrimination training could promote transfer of control in an adult with Down syndrome. The participant was taught to select photographs and pictures of kitchen tools when provided with dictated names. Then, he completed a text‐based activity schedule, matched printed words to photographs, and orally named printed words without direct training.     

Depression in primary Sjögren’s syndrome: a systematic review and meta-analysis

There is substantial uncertainty regarding the prevalence of depression in Primary Sjögren’s syndrome (pSS). We conducted a systematic review aiming to evaluate the association of pSS with depression. PubMed, Web of Science, VIP, CNKI and Wanfang database were searched to find the published literatures (from these databases established to October 2016). Studies were screened according to inclusion and exclusion criteria and the qualities of included studies were evaluated. The data was analyzed using Revman5.2 software. A total of 12 studies including 1917 patients were eligible for inclusion in the systematic review and meta-analysis. In this meta-analysis, Severity of depression was assessed using psychometric measures, such as PHQ-9; HADS; CES-D; Zung depression scale and BDI. The result revealed that pSS was associated with an increased prevalence of depression (summary odds ratio (OR) = 5.36, 95% CI: 4.05–7.09, P < 0.01). The depression score in pSS patients (standardized mean difference (SMD) = 1.47, 95% CI: 0.81–2.12, P < 0.01) were higher than in the control group. Depression is highly prevalent in pSS than in healthy controls. Early recognition and appropriate intervention are therefore essential to reduce the negative impact of depression on the patient’s quality of life and outcome of their disease.     

An experiment on measuring awareness of stuttering in individuals with Down syndrome

BackgroundAwareness of stuttering is likely to depend upon the development of the metalinguistic skill to discriminate between fluent speech and stuttering and the ability to identify one’s own speech as fluent or stuttered. Presently, little is known about these abilities in individuals with Down syndrome (DS).PurposeThis study investigates whether individuals with DS and typically developing (TD) children who stutter and who do not stutter differ in their ability to discriminate between fluent speech and stuttering. The second purpose of this study is to discover if this ability is correlated with their self-identification ability.MethodAn experiment to investigate awareness with tasks for discrimination of stuttering and self-identification was developed. It was administered to 28 individuals (7–19 years) with DS, 17 of them stutter and 11 do not, and 20 TD children (3–10 years), 8 of them stutter and 12 do not. Skills to discriminate stuttering were compared between these groups and correlated with self-identification within these groups. The influence of stuttering severity and developmental/chronological age on their ability to discriminate was also investigated.ResultsThe ability to discriminate does not differ significantly between the DS and TD group, but is highly influenced by developmental age. This ability correlates with self-identification but only for the TD individuals who speak fluently.ConclusionThe ability to discriminate matures around the age of 7 and conscious awareness may rely on this ability. Differences between the present findings and earlier studies suggest that differentiation in levels and types of awareness is warranted.