系统生物学引导阿尔茨海默病治疗新策略

阿尔茨海默病(AD)是一种发生于中老年期的退行性脑神经变性疾病,临床上以进行性智能衰退,伴有人格改变为主要特征.其发病过程涉及许多途径和靶点.现代医学认为脑内胆碱能递质功能紊乱、β-淀粉样蛋白沉积、tau-蛋白过磷酸化、炎症反应以及基因突变等在其发病过程中起着重要作用.治疗方法从胆碱酯酶抑制剂、神经递质受体阻滞剂到补气活血、益精填髓、化痰开窍等中医药疗法不等.但抑制剂、阻滞剂等药物阻滞疗法,从单一环节阻断发病途径,忽略了AD发病的整体复杂性.中医辨证论治从整体观念出发,在宏观上治疗AD,对AD的发病缺乏微观深入研究.AD治疗需要借助于“系统生物学”理论的指导.中西医结合为AD的治疗提供了较为科学、有效的途径和发展空间.     

中风病简化辨证的哲学思考

中风病分阴证和阳证为纲辨治,不但有是充分的实践依据和理论基础,而且符合哲学的否定之否定定律。从中风病简化辨证的必要性,中风病阴阳辨证的发展,中风病的病因病机、证候属性可从阴阳两方面认识,中风病阴阳为纲辨证方法符合哲学否定之否定定律4方面进行了论述。     

无证可辨浅识及对策

辨证论治是中医学精髓。无证可辨的情况,究其原因,一方面与医者辨证方法和技能有关,另一方面确实存在无证可辨的现象。为提高辨证水平,医者既要重视病性特点、病因、六经病辨证特色;也要积极引入中医“病”的概念和微观辨证,因为中医辨病在特定情况下可弥补辨证的不足,而微观辨证的深入研究则可能为无证可辨提供客观依据。为此,才可在实践中正确处理无证可辨的尴尬,并使中医诊断学内容臻备。     

医学专业研究生扩招对其培养目标与模式的影响

从医学专业研究生招生的现状及目前研究生培养目标和模式中存在问题出发,分析了我国医学专业研究生招生规模不断扩大对研究生教育的影响,并针对以上变化和问题提出针对逐渐膨胀的医学研究生群体,应采取新的管理及教育模式,从而使研究生的质量和水平得到全面的提高,使我国医学研究生教育水平逐渐与世界接轨.     

“病中辨证”是证发展的必然

在疾病的发展过程中,一般存在着病和证的两种演变,相对于病而言,证有着更高层次的组织方式,有自身发展规律,反映的是机体整体状态。这种对证的诠释有利于中西医理论间的接轨,使证研究更容易被现代医学理论所接受,是中医进一步发展的要求,病证二者并不矛盾,而是互补,共同提供了对疾病的完整认识。     

Elucidating the psychosocial context of ‘post‐concussion syndrome’ (PCS): a case study from post‐Milan systemic family therapy

The literature on post‐concussion syndrome (PCS) following mild head injury includes biopsychosocial formulations. However, it is contended that the complexities of the psychosocial remain conceptually underdeveloped. An engagement with this complexity is presented via a case study from post‐Milan systemic family therapy. The work described is with grandparents, a mother and daughter. The latter two both initially experienced PCS following a road traffic accident, yet demonstrated contrasting outcomes in the year post‐injury. Implications for family therapy services and the wider literature are discussed.     

感染后与非感染后肠易激综合征的多维特点

探讨感染后(PI)与非感染后肠易激综合征(NPI-IBS)的临床,精神心理,组织学特点。取IBS患者和正常人进行问卷调查,了解其多维特点。分别检测肥大细胞的数目。结果显示:(1)PI-IBS与NPI-IBS患者临床、心理特征不同;(2)IBS两组患者肥大细胞的数目无差异,与对照组比较差异明显。因此认为PI-IBS和NPI-IBS有特征差异,对临床治疗有一定指导意义。     

浅述空肠弯曲菌诱发格林-巴利综合征的机制和防控

弯曲菌是全球范围流行的细菌性肠道病原菌之一,对人致病的主要是空肠弯曲菌,HS:19等特定血清型空肠弯曲菌感染是诱发人格林-巴利综合征(GBS)的重要前驱因子。本文浅述了空肠弯曲菌诱发格林-巴利综合征的可能机制,并提出了防控的几点建议。     

Prior sensitivity in theory testing: An apologia for the Bayes factor

A commonly voiced concern with the Bayes factor is that, unlike many other Bayesian and non-Bayesian quantitative measures of model evaluation, it is highly sensitive to the parameter prior. This paper argues that, when dealing with psychological models that are quantitatively instantiated theories, being sensitive to the prior is an attractive feature of a model evaluation measure. This assertion follows from the observation that in psychological models parameters are not completely unknown, but correspond to psychological variables about which theory often exists. This theory can be formally captured in the prior range and prior distribution of the parameters, indicating which parameter values are allowed, likely, unlikely and forbidden. Because the prior is a vehicle for expressing psychological theory, it should, like the model equation, be considered as an integral part of the model. It is argued that the combined practice of building models using informative priors, and evaluating models using prior sensitive measures advances knowledge.