The perception of biological and mechanical motion in female fragile X premutation carriers

Previous studies reported impaired visual information processing in patients with fragile X syndrome and in premutation carriers. In this study, we assessed the perception of biological motion (a walking point-light character) and mechanical motion (a rotating shape) in 25 female fragile X premutation carriers and in 20 healthy non-carrier controls. Stimuli were moving stimulus dots embedded among a cloud of noise dots. Sensitivity (d′) for motion detection was determined. Emotional symptoms were assessed by Hamilton’s depression and anxiety rating scales. Results revealed that the premutation carriers displayed lower sensitivities for biological and mechanical motion relative to the non-carriers. This deficit was more pronounced in the case of biological stimuli. The premutation carriers displayed higher depression and anxiety scores relative to the non-carriers. Higher depression, but not anxiety, scores were associated with decreased sensitivity for biological, but not mechanical, motion in the carrier group. These results suggest that motion perception deficits are detectable in fragile X premutation carriers, and that the impairment of biological motion perception is associated with depressive symptoms.     

Recognition and mental manipulation of body parts dissociate in locked-in syndrome

Several lines of evidence demonstrate that the motor system is involved in motor simulation of actions, but some uncertainty exists about the consequences of lesions of descending motor pathways on mental imagery tasks. Moreover, recent findings suggest that the motor system could also have a role in recognition of body parts. To address these issues in the present study we assessed patients with a complete damage of descending motor pathways (locked-in syndrome, LIS) on the hand laterality task, requiring subjects to decide whether a hand stimulus in a given spatial orientation represents a left or a right hand. LIS patients were less accurate than healthy controls in judging hand laterality; more importantly, LIS patients’ performance was modulated by spatial orientation of hand stimuli whereas it was not affected by biomechanical constraints. These findings demonstrate a dissociation between spared hand recognition and impaired access to action simulation processes in LIS patients.     

Crib death: a biobehavioral phenomenon?

In developed countries, more children under 1 year of age die of crib death (sudden infant death syndrome, SIDS) than of all other causes combined. Researchers and clinicians have proposed many possible causes of SIDS, but the abrupt, unexpected death of some babies remains mysterious and frightening. Although infant behavior may explain some of these deaths, scant attention has addressed behavioral characteristics of babies who die without medical explanation. Any explanation of SIDS must account for the fact that most SIDS deaths occur at 2 to 5 months of age, acknowledging that a protective mechanism appears to spare babies before 2 months but then disappears. The respiratory occlusion reflex serves as an initial defense against smothering and can provide such an explanation. Infantile reflexes wane, after providing opportunities for learned responses to be acquired. During this well-documented neurobehavioral transition from subcortical to cortically mediated responding, some babies, viable for the first 2 months, may become especially vulnerable if they fail to acquire sufficiently strong defensive behaviors needed to prevent occlusion after the waning of the life-preserving reflex. Recent success of back-to-sleep directives, urging that babies sleep on their backs to avoid smothering, supports this hypothesis.     

Neuropsychological Performance in Gulf War Era Veterans: Neuropsychological Symptom Reporting

Relationships between broad-based health symptoms and neuropsychological performance have been investigated previously in Gulf War (GW) veterans. However, very little has been done to assess relationships between severity of neuropsychological symptom complaints and performance on objective neuropsychological tests. In this study, relationships between level of self-reported neuropsychological symptom severity and objective neuropsychological performance measures were investigated. Participants included 240 veterans from three GW-era cohorts: GW-deployed veterans recruited from Ft. Devens, MA, (n = 142) and from New Orleans, LA (n = 51), and veterans deployed to Germany from a Maine National Guard unit (n = 47). Findings suggest that level of subjective neuropsychological complaints was associated primarily with mood symptoms in GW-era veterans. Among GW-deployed troops, high neuropsychological symptom reporters endorsed more tension, fatigue, and confusion and less vigor than those reporting fewer cognitive complaints. Current findings emphasize the importance of independent assessment of subjective symptoms and objective neuropsychological performance.     

Factors of parricide: Allowance of the use of battered child syndrome as a defense

Children who kill a parent may be mentally ill or dangerously antisocial, but most often they are severely abused. However, most abused children do not resort to killing a parent. Children who do commit murder do so out of desperation when family members and friends have failed to help them. This article discusses issues surrounding allowance of the defense of battered child syndrome as a justification for parricide. An argument will be made for the expansion of the self-defense claim to include battered child syndrome.     

Chickens or eggs? A follow‐up case study exploring links between physical and psychological impact of Tourette's syndrome and sexual abuse

This follow‐up case study highlights the complex relationship when working at the interface between physical and psychological symptoms. The paper draws upon conversations between an ex‐client and myself, held seven years after the end of our six year therapeutic relationship. Conversational interviews, based upon social constructionist beliefs, led to an unexpected exploration of the client's subsequent diagnosis of Tourette's syndrome (given several years after the end of therapy) and evolved into a struggle to reach a shared understanding of how she now makes connection between her problem with eating in public, her neck and facial tics, and childhood sexual abuse. Our research relationship provided both of us with a rare opportunity to reflect upon how she had made meaning of her counselling and its outcomes. The paper draws attention to the impact of counselling and therapy discourses concerning sexual abuse on the work we did at the time and asks how that work might be different today. It also helps us understand the layers of complexity and ambiguity contained within the client's stories. This multi‐layered case study represents the overlap and ‘messiness’ that mirrors the ‘lived experience’ of the persons involved, and provides an example of how co‐constructed research conversations can evoke stories that create meaning as they are told.     

On the psychodynamics of collecting1

The urge to collect is a ubiquitous phenomenon which has anthropological, sociobiological and individual psychodynamic roots, but occurs far more frequently among men than women. The author examines the reasons for this gender difference and defi nes systematic collecting to distinguish it from addictive, obsessive and messy collecting, and from related phenomena such as perversion. The mode of collecting and choice of object are important indicators as to the unconscious psychodynamics of a collector and offer opportunity to describe his structural level. Collecting ranges across a broad spectrum, from an ego‐syntonic integrated mode, i.e. sublimation, to a neurotic defence against pre‐oedipal or oedipal traumas and confl icts. Alongside this drive‐theoretical approach, object and Kleinian theory are also applied to the understanding of collecting. Collecting represents a specifi c form of object relating and way of handling primary loss trauma, which is different from addiction, compulsion, or perversion. Under certain circumstances collecting can also result in a successful Gestalt or way of life. The paper concludes with a case study showing how collecting develops from a pre‐oedipal to a more integrated oedipal mode during the course of the analysis, which is refl ected in changes in the transference.     

重新审视肠易激综合征

肠易激综合征(IBS)作为新近日益受到重视的疑难疾病,以其固有的复杂性冲击着西医传统的疾病观。以其高发病率和对人类生活质量的严重影响促使复杂性探索研究在医学中应用并促进东方整体观在现代医学中复兴,从而用于解决诸如肠易激综合征等的医学疑难。重新审视IBS这种典型的心身相关特点显著的功能性疾病,促进对医学疑难问题研究和认识中观念的更新,特别是促进整体观在医学研究中的深化,从而有助于寻找到更有效的医学疑难病的解决方法。     

中医证的本质

根据现代医学理论、哲学原理等,对中医证本质的科学内涵进行理论探讨,提出中医证的本质是基因表达的改变,用现代科学理论阐明中医证的本质具有重大科学意义.     

Health and Sickness: The Meaning of Menstruation and Premenstrual Syndrome in Women's Lives

The experience of menstruation was examined through an analysis of women's narratives in order to understand perceptions of menstrual cycle changes. Research within a medical anthropology perspective was conducted with 43 women who volunteered for a study on the knowledge and understanding of menstruation and premenstrual syndrome (PMS) in Winnipeg, Manitoba, Canada, from 1997 to 1999. Although most women accepted the PMS label and placed their cyclic changes within the realm of sickness, a small group of women were identified who conceptualized their cyclic changes in an extremely positive way thus reframing their experiences. More positive perceptions of menstrual changes may have a significant impact on the reevaluation of menstrual cycle fluctuations as sickness without devaluing the experiences of those women with severe changes.