A cross-syndrome study of the development of holistic face recognition in children with autism, Down syndrome, and Williams syndrome

We report a cross-syndrome comparison of the development of holistic processing in face recognition in school-aged children with developmental disorders: autism, Down syndrome, and Williams syndrome. The autism group was split into two groups: one with high-functioning children and one with low-functioning children. The latter group has rarely been studied in this context. The four disorder groups were compared with typically developing children. Cross-sectional trajectory analyses were used to compare development in a modified version of Tanaka and Farah’s part–whole task. Trajectories were constructed linking part–whole performance either to chronological age or to several measures of mental age (receptive vocabulary, visuospatial construction, and the Benton Facial Recognition Test). In addition to variable delays in onset and rate of development, we found an atypical profile in all disorder groups. These profiles were atypical in different ways, indicating multiple pathways to, and variable outcomes in, the development of face recognition. We discuss the implications for theories of face recognition in both atypical and typical development, including the idea that part–whole and rotation manipulations may tap different aspects of holistic and/or configural processing.     

Henry Cavendish and Asperger’s syndrome: A new understanding of the scientist

Although it has recently been suggested that Henry Cavendish (1731–1810) suffered from Asperger’s syndrome (James, 2005; Sacks, 2001), there has yet to be a systematic exploration of this claim. For various reasons, Cavendish is considered here through the diagnostic framework described by Gillberg (1989), with further support from the DSM-IV (APA, 1994). The potential for such a retro-diagnosis is evident, given Cavendish’s biographers’ lament of Cavendish as the ‘incomplete man’: the oddly misanthropic man characterised by negations. Such an impression is evident in the memoirs of Cavendish’s contemporaries but finds its best expression in Wilson’s (1851) biography. With a new and cautious interpretation from an Asperger’s syndrome perspective, this fragmented picture dissipates and Cavendish emerges as a man of remarkable intellect whose syndrome stunted his social development and expression, yet so crucially enabled his research into a paradoxically catholic taste of scientific study. Topics relevant to a ‘retro-diagnosis’ are first addressed, before Cavendish is compared to Gillberg’s and the DSM-IV criteria.     

Lifespan changes in working memory in fragile X premutation males

Fragile X syndrome is the world’s most common hereditary cause of developmental delay in males and is now well characterized at the biological, brain and cognitive levels. The disorder is caused by the silencing of a single gene on the X chromosome, the FMR1 gene. The premutation (carrier) status, however, is less well documented but has an emerging literature that highlights a more subtle profile of executive cognitive deficiencies that mirror those reported in fully affected males. Rarely, however, has the issue of age-related declines in cognitive performance in premutation males been addressed. In the present study, we focus specifically on the cognitive domain of working memory and its subcomponents (verbal, spatial and central executive memory) and explore performance across a broad sample of premutation males aged 18–69 years matched on age and IQ to unaffected comparison males. We further tease apart the premutation status into those males with symptoms of the newly identified neurodegenerative disorder, the fragile X-associated tremor/ataxia syndrome (FXTAS) and those males currently symptom-free. Our findings indicate a specific vulnerability in premutation males on tasks that require simultaneous manipulation and storage of new information, so-called executive control of memory. Furthermore, this vulnerability appears to exist regardless of the presence of FXTAS symptoms. Males with FXTAS symptoms demonstrated a more general impairment encompassing phonological working memory in addition to central executive working memory. Among asymptomatic premutation males, we observed the novel finding of a relationship between increased CGG repeat size and impairment to central executive working memory.     

New insights into the formation and duration of flashbulb memories: Evidence from medical diagnosis memories

Flashbulb memories are vivid and salient memories for the moment one hears about a surprising, emotional, and significant event. The current research examined flashbulb memories for a loved one's medical diagnosis, focusing on individual and situational factors associated with memory development and endurance over time. An online survey collected memory narratives and subjective ratings from 309 mothers who received a diagnosis of Down syndrome for their child. Time since diagnosis ranged from 1 month to 52 years. Using two independent measures, the Flashbulb Memory Checklist and the Autobiographical Memory Questionnaire, we found that a majority of diagnosis memories qualified as flashbulb memories, even 20 years or more after the event. Importantly, support from the medical staff at diagnosis emerged as a critical variable related to flashbulb memory development and the persistence of these flashbulb memories over time.     

《针灸治疗学》教材的改革应当紧跟临床需要——建立现代针灸学临床诊疗体系的思考

以“辨证治疗”为主体的针灸教材,与针灸临床实践需要相脱节。主要的针灸专业杂志的文献多数采用“辨病治疗”模式。脱离临床的针灸学课本知识制造了“学非所用,用非所学”的尴尬状态。虽然新版针灸教材仍然以“辨证诊疗”为主体,但和旧版教材比较仍然展现了针灸临床“辨病治疗”模式的发展趋势。为了适应针灸临床的实践需要,《针灸治疗学》教材应当进行更为务实的改革。建立现代针灸学临床诊疗体系既是适应环境变化的客观需要,也是针灸学术发展的内在要求。基于数据和事实,从学术发展的历史角度,论述了针灸临床的辨证施治模式向辨病治疗模式转化的客观趋势。     

艾滋病流行终结之路的困境与挑战

为了深入分析艾滋病流行终结之路的困境与挑战,从国际形势出发,回顾历史因素,提出在国际社会为了终结这一全球性公共卫生问题付出了巨大努力的基础上,面对新型冠状病毒疫情对全球艾滋病防治工作造成巨大冲击,以及各国所面临的关于政治、经济、医疗等方面的困境与挑战。并以我国为例,提出艾滋病流行终结之路需要继续坚持采取中国特色方案与常规防治相结合的策略,通过弘扬中华民族传统文化、发挥中医中药的优势,从而加快脚步,缩短与目标的距离。

     

Exploratory behavior and developmental skill acquisition in infants with Down syndrome

Infants learn about objects by exploring them. Typically developing infants actively explore objects through visual, manual, and oral modalities. Attenuated exploratory behavior has been observed in various neurodevelopmental disorders, including Down syndrome (DS), presumably limiting learning options. However, a direct link between exploration and overall developmental functioning has not been characterized. This study used a Latent Profile Analysis framework to examine within-syndrome variability in exploratory behavior in infants with DS and the developmental correlates of different exploratory behavior profiles. Participants were 45 infants with DS (CA = 9.58 months; SD = 3.62) who completed an object exploration activity and the Bayley Scales of Infant Development-III (BSID-III; Bayley, 2006). Exploration behavior was coded for the percentage of time engaged in visual, manual, and oral exploration. Results indicated that a 2-profile solution provided the best model fit for exploratory behavior, yielding profiles that represented either an Active (57.78% of the sample) or a Passive Exploratory (42.22% of the sample) profile. The Active Exploratory profile was associated with significantly higher age equivalent scores on the BSID-III Cognitive, Communication, and Motor domains than the Passive Exploratory profile. Other factors, such as sex and biomedical risk factors, were not associated with exploratory profiles. These findings offer a more nuanced understanding of early within-syndrome heterogeneity in DS, and demonstrate that impoverished early exploratory behavior may serve as an important indicator of increased risk for more pronounced developmental delays in DS.     

The perception of biological and mechanical motion in female fragile X premutation carriers

Previous studies reported impaired visual information processing in patients with fragile X syndrome and in premutation carriers. In this study, we assessed the perception of biological motion (a walking point-light character) and mechanical motion (a rotating shape) in 25 female fragile X premutation carriers and in 20 healthy non-carrier controls. Stimuli were moving stimulus dots embedded among a cloud of noise dots. Sensitivity (d′) for motion detection was determined. Emotional symptoms were assessed by Hamilton’s depression and anxiety rating scales. Results revealed that the premutation carriers displayed lower sensitivities for biological and mechanical motion relative to the non-carriers. This deficit was more pronounced in the case of biological stimuli. The premutation carriers displayed higher depression and anxiety scores relative to the non-carriers. Higher depression, but not anxiety, scores were associated with decreased sensitivity for biological, but not mechanical, motion in the carrier group. These results suggest that motion perception deficits are detectable in fragile X premutation carriers, and that the impairment of biological motion perception is associated with depressive symptoms.     

Recognition and mental manipulation of body parts dissociate in locked-in syndrome

Several lines of evidence demonstrate that the motor system is involved in motor simulation of actions, but some uncertainty exists about the consequences of lesions of descending motor pathways on mental imagery tasks. Moreover, recent findings suggest that the motor system could also have a role in recognition of body parts. To address these issues in the present study we assessed patients with a complete damage of descending motor pathways (locked-in syndrome, LIS) on the hand laterality task, requiring subjects to decide whether a hand stimulus in a given spatial orientation represents a left or a right hand. LIS patients were less accurate than healthy controls in judging hand laterality; more importantly, LIS patients’ performance was modulated by spatial orientation of hand stimuli whereas it was not affected by biomechanical constraints. These findings demonstrate a dissociation between spared hand recognition and impaired access to action simulation processes in LIS patients.     

全身炎症反应综合征治疗新策略——胆碱能抗炎通路

全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)是各种原因刺激机体产生失控的全身性炎症反应的统称,严重者可致多器官功能障碍综合征。迷走神经及其递质乙酰胆碱所构成的胆碱能抗炎通路可以有效抑制局部和全身炎症反应。本文将从胆碱能抗炎通路的作用特点分析激活胆碱能抗炎通路对全身炎症反应综合征的潜在治疗前景。