Socio-cultural selection and the sculpting of the human genome: Cultures’ directional forces on evolution and development

This paper argues for culture as a significant determinant of the modern human genome. As progress in the fields of genetics and evolutionary biology have gained greater insights into evolutionary process, aspects of classical proposals explaining how phenotypic responses to environmental experience could make their way into the genotype have returned in new guises. Recent proposals recognize environmental context as a key source of genetic variation by directly altering selection pressures to mask and unmask adaptive value of expressed traits, by reorganizing the combination and expression of genes during ontogeny to provide novel variants for selection, and by influencing developmental trajectories through epigenetic systems acutely sensitive to ontogenetic contexts. The emergence of a robust human socio-cultural niche, shielding humans from more proximate evolutionary pressures that marked our ancestral evolution, has arguably provided the strongest directive force on modern human evolution. Language is discussed as an exemplar of a cultural niche with a powerful self-organizing dynamic and the potential to dramatically alter the human genome.     

Impact of genetic testing on causal models of heart disease and arthritis: An analogue study

Abstract

An analogue study investigated the impact of genetic testing on perceptions of disease. Using a 2 × 2 design, participants (n = 212) imagined receiving the information that they were at increased risk for either heart disease or arthritis. The type of risk information was either genetic or unspecified. Presentation of genetic risk information resulted in the condition being perceived as less preventable. Causal models of disease where investigated using principal components analysis. When hem disease was the stimulus condition, attributions to genes and chance were positively associated following unspecified risk information, and negatively associated following genetic risk information. When arthritis was the stimulus condition, presentation of genetic risk information was associated with attributions to genes becoming separated from the other attributions. One explanation for this is that providing genetic risk information may decrease perceptions of a sense of randomness or uncertainty in disease causation. The extent to which these effects occur in clinical populations. and their behavioural consequences. needs to be established.     

Openness to psychological explanations and treatment among people with Fibromyalgia versus Rheumatoid Arthritis

Objective: The classic perspective in the psychosomatic literature is that patients with medically unexplained syndromes do not acknowledge psychologically-based causes for their conditions and will not engage in psychological treatments. These assumptions were tested by contrasting the illness models and reported treatment experiences of individuals with fibromyalgia (FM), a syndrome with a currently unknown organic origin, with those of individuals with rheumatoid arthritis (RA), a ‘legitimate’ (i.e. organic) condition.

Method: 193 patients with FM and 176 with RA completed measures assessing their views about the causes of their condition, the treatments they had used and their judged effectiveness.

Results: Contrary to prediction, compared to patients with RA, patients with FM were more likely to endorse psychological causes for their condition and reported having used more psychological management approaches. Moreover, patients with FM considered psychological approaches to be more effective than narcotics.

Conclusion: These findings indicate that patients with FM do not react defensively to the implication of psychogenic causes. Rather, as a group, they tend to acknowledge both the psychosocial influences on and the effectiveness of psychological management approaches for their condition.     

Illness perceptions and distress in women at increased risk of breast cancer

Variation in the levels of distress in women at increased risk of breast cancer has been reported, yet there is limited understanding of the factors that are associated with heightened distress in this population. This study took a theoretical approach using Leventhal's Self Regulatory Model (SRM) to understand variation in distress levels. The study examined the associations between perceptions of breast cancer and distress in women at increased risk of breast cancer, and a comparison sample with no experience of the disease in their social environment. Questionnaire data from 117 women at increased risk of breast cancer and 100 comparison women were analysed. Women at increased risk of breast cancer showed comparable levels of general distress but significantly higher levels of cancer specific distress than the comparison group. There were few differences in illness perceptions between the samples, although a number of cognitive perceptions of breast cancer were related to both general and cancer specific distress in the increased risk sample, but not in the comparison sample. The results suggest that the SRM provides a useful framework to explore the psychological response to genetic risk. Further research is required in this population to examine illness perceptions in more detail, validate quantitative measures of illness perceptions, and examine interactions between risk perception and the SRM constructs.     

Developing Standard Recommendations (Guidelines) for Genetic Counseling Practice: A Process of the National Society of Genetic Counselors

The National Society of Genetic Counselors (NSGC) supports the development of practice recommendations (guidelines) in the field of genetic counseling. This paper reviews the basic components of NSGC genetic counseling practice recommendations as well as the process for formal adoption of such documents, as approved by the Board of Directors of the NSGC.     

Prosocial behavior in families: Moderators of resource sharing

Archival studies of within-family prosocial behavior (Judge & Hrdy, 1992; Smith, Kish, & Crawford, 1987) have shown that inheritance patterns support Hamilton’s (1964) theory of inclusive fitness, such that people will more of their estates to relatives of closer genetic relatedness. In a survey-based simulation of these studies, students allocated one of three lotteries to their blood relatives. As expected, participants allocated greater proportions of their lotteries to relatives of greater genetic relatedness. This effect became stronger with decreasing lottery amounts. Relatives of certain relatedness were favored over relatives of uncertain relatedness (via paternal uncertainty), and this effect was stronger among those with less money to allocate. Male participants tended to favor their young female relatives over their young male relatives when given the smallest lottery, but this sex preference reversed when male participants were given the largest lottery. In general, scarcer resources led to more evolutionarily conservative investment strategies.     

Genetic Counseling for Fragile X Syndrome: Recommendations of the National Society of Genetic Counselors

The National Society of Genetic Counselors' (NSGC) recommendations for fragile X syndrome (FXS) genetic counseling are intended to assist health care professionals who provide genetic counseling for individuals and families in whom the diagnosis of FXS is strongly suspected or has been made. The recommendations are the opinions of genetic counselors with expertise in FXS counseling and are based on clinical experience, a review of pertinent English language medical articles, and reports of expert committees. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. These recommendations do not displace a health care provider's professional judgment based on the clinical circumstances of a particular client.     

A Method for Analyzing Videotaped Genetic Counseling Sessions

This study describes the development and evaluation of a multi-item scale for analyzing the genetic counseling process, the Manchester Observation Code (MOC) for genetic counseling. The instrument is specific to the field of genetic counseling and is designed for analysis of the communication between counselor and client. Coding is done directly from videotaped sessions. Because communication is the means by which genetic counseling is accomplished, the method measures four relevant components of communication: (1) grammatical form, (2) purpose, (3) subject, and (4) cue source. The instrument enables an observer to code the counselor's statements into these four components. Three videotaped sessions were used to measure interrater reliability, or the consistency of rating for each of the four communication domains using this method. Three videotaped sessions were also used to measure test-retest reliability, or the consistency of the designed method from one time to another. A total of 21 videotaped sessions were tested using the method. A statistical measure of reliability established consistency of the designed method; Cohen's kappa yielded 0.7 for interrater reliability and 0.79 for test-retest reliability. These findings suggest this instrument may be used to identify important elements of the genetic counseling process.     

Analysis of regional environment and regional innovation strategy based on cybernetics

In this paper, based on the perspective of carbon emissions, the regional environment and regional innovation strategies were analyzed by using cybernetics. The main idea was to calibrate the diesel engine simulation model with predictive function based on the data collected from the bench test, and then according to the simulation model, the genetic algorithm was applied to optimize the EGR parameters and fuel injection parameters with the target of emission generation and output torque. First of all, the combustion process and emission performance of diesel engine with internal exhaust re-circulation were studied by genetic algorithm, and the genetic algorithm model was constructed. Then, the genetic algorithm program was written based on Matlab. In addition, taking the NOx emission as the target, and the Soot emission and the output torque of the original machine as constraints, through the joint simulation of Matlab and GT-Power, the EGR parameters and fuel injection parameters of the 10% to 50% load conditions were optimized at the speed of 1500 r/min and 2000 r/min. Finally, the validity of this method was verified and analyzed.     

Neuroticism and extraversion share genetic and environmental effects with negative and positive mood spillover in a nationally representative sample

Work-family spillover research focuses on how negative and positive moods in one life domain carry over to another. Domain-specific etiologies (e.g., family conflict) are often emphasized to explain spillover. Yet, strong correlations exist between spillover variables of the same emotional valence but originating from different domains, suggesting individual differences in the tendencies to prolong mood-states. The current study (N = 1143 individuals) examined whether these general tendencies are associated with neuroticism and extraversion and how genetic and environmental effects contribute to these associations. Findings revealed that neuroticism and extraversion are related to these tendencies through both genetic and environmental pathways.