This paper starts by considering an argument for thinking that predictive processing (PP) is representational. This argument suggests that the Kullback–Leibler (KL)-divergence provides an accessible measure of misrepresentation, and therefore, a measure of representational content in hierarchical Bayesian inference. The paper then argues that while the KL-divergence is a measure of information, it does not establish a sufficient measure of representational content. We argue that this follows from the fact that the KL-divergence is a measure of relative entropy, which can be shown to be the same as covariance (through a set of additional steps). It is well known that facts about covariance do not entail facts about representational content. So there is no reason to think that the KL-divergence is a measure of (mis-)representational content. This paper thus provides an enactive, non-representational account of Bayesian belief optimisation in hierarchical PP. 相似文献
In his article, “Genetic Engineering, Virtue-First Enhancement, and Neo-Irenaean Theodicy,” Mark Walker has ventured farther into science more than most when it comes to exploring theodicy. After exposing the Achilles heel of the traditional free-will defense, Walker develops the Irenaean and Augustinian responses to the anthropic problem. Most importantly for this discussion, Walker proceeds to propose Genetic-First-Enhancement as part of his neo-Irenaean theodicy formulation. Overall, there are two major concerns I raised: the impossibility of a gradient morality in the presence of free will, and the scientific impossibility of Genetic Virtue Program. However, my claims are falsifiable if future genetic modifications do indeed improve morality. Before that is proven, I agree with Walker that, yes, we should play God, albeit, with his proposed virtue-first program. 相似文献
In 2009, Mark Walker first proposed the Genetic Virtue Project, advancing that science should explore using genetic engineering to eliminate moral evils just as it attempts to eliminate natural ones like disease. This seemed like an issue for the far future given the unique challenges. Walker focused on the wrong aspect of personhood, however, as moral engineering of the brain appears to be a more likely possibility. As early aspects of moral engineering the brain are in development, especially through the manipulation of the neural correlates of religious and political beliefs, emotions, and behaviors, I consider several issues surrounding this project so as to protect individual rights and prevent future harms. I advance an internal criterion for the field called Acceptability Across Ideologies to serve as a guide to protect against coercive and harmful technologies and analyze how current laws protecting cognitive liberty are lacking and in need of revision. 相似文献
The characteristics of various genetic syndromes have included “stuttering” as a primary symptom associated with that syndrome. Specifically, Down syndrome, fragile X syndrome, Prader-Willi syndrome, Tourette syndrome, Neurofibromatosis type I, and Turner syndrome all list “stuttering” as a characteristic of that syndrome. An extensive review of these syndromes indicated clients diagnosed with these syndromes do show evidence of nonfluency patterns, but not all would be considered stuttering. Many of the syndromes are marked by degrees of mental retardation that probably contribute to a higher than average prevalence of stuttering, as well as a higher than average prevalence of other fluency disorders (when compared to the population at large).
An in-depth analysis of the available data indicates that some of these genetic syndromes show patterns of stuttering that may be indicative of only that syndrome (or similar syndromes) that can be differentially diagnosed from developmental stuttering. Among these patterns are the word-final nonfluencies noted in Prader-Willi syndrome; the presence of stuttering in the absence of secondary behaviors noted in Prader-Willi syndrome and; the presence of palilalia, word-final and word-medial nonfluencies, and word-medial and word-final nonfluencies in Tourette syndrome. Implications for future research are discussed in light of these findings.
Educational objectives: The reader will be able to: (1) describe the various different genetic syndromes that are associated with fluency disorders; (2) describe the types of nonfluencies that are associated with the major types of genetic syndromes that have fluency disorders; (3) describe the behaviors that may assist in differentially diagnosing different types of speech characteristics associated with various genetic syndromes. 相似文献
These cancer genetic counseling recommendations describe the medical, psychosocial and ethical implications of identifying
at-risk individuals for hereditary breast and ovarian cancer (HBOC) through cancer risk assessment, with or without genetic
susceptibility testing. They were developed by members of the Practice Issues Subcommittee of the National Society of Genetic
Counselors’ Familial Cancer Risk Counseling Special Interest Group. The information contained in this document is derived
from extensive review of the current literature on cancer genetic risk assessment as well as the professional expertise of
genetic counselors with significant experience in education and counseling regarding hereditary breast and ovarian cancer.
Critical components of the process include the ascertainment of medical and family histories, determination and communication
of cancer risk, assessment of risk perception, education regarding the genetics of HBOC, discussion of molecular testing for
HBOC if appropriate (including benefits, risks and limitations) and any necessary follow-up. These recommendations do not
dictate an exclusive course of management or guarantee a specific outcome. Moreover, they do not replace the professional
judgment of a health care provider based on the clinical situation of a client. 相似文献
Personal values are motivational sources for an individual’s actions [Hitlin and Piliavin (Annual Review of Sociology 30:359–393,
2004)]. Genetic counselors’ values may influence their behaviors in clinical practice, but a profile of their personal values
has not been identified empirically. In this study, 292 genetic counselors completed the Schwartz Universal Values Questionnaire
(SUVQ; Schwartz, S. H. (1992). Universals in the content and structure of values: Theoretical advances and empirical tests
in 20 countries. In M. Zanna (Ed.), Advances in experimental social psychology (pp. 1–65). Boston, MA: Academic.), a widely used measure of value types, and provided information about their demographic
characteristics. Results indicate that respondents highly valued benevolence, self-direction, achievement, and universalism indicating a strong pattern of concern for the welfare of others. They placed considerably less value on stimulation, tradition, and power, which reflect personal interests. Respondents who reported practicing a religion scored significantly lower on stimulation and hedonism and higher on tradition and spirituality than those not practicing; married respondents and parents scored significantly lower on stimulation and achievement; and males scored higher on power than females. The value types are described, and training and research recommendations are provided. 相似文献
The purpose of this paper is to report the outcome of a collaborative project between the Fragile X Research and Treatment
Center at the Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute at the University of California at
Davis, the National Fragile X Foundation (NFXF), and the Centers for Disease Control and Prevention (CDC). The objective of
this collaboration was to develop and disseminate protocols for genetic counseling and cascade testing for the multiple disorders
associated with the fragile X mental retardation 1 (FMR1) mutation. Over the last several years, there has been increasing insight into the phenotypic range associated with both
the premutation and the full mutation of the FMR1 gene. To help develop recommendations related to screening for fragile X-associated disorders, four, two day advisory focus
group meetings were conducted, each with a different theme. The four themes were: (1) fragile X-associated tremor/ataxia syndrome
(FXTAS); (2) premature ovarian failure (POF) and reproductive endocrinology; (3) psychiatric, behavioral and psychological
issues; and (4) population screening and related ethical issues. 相似文献
A genetic counselor is often faced with the difficult task of conveying a set of complex and highly abstract factors associated
with the client's risk of developing a familial disorder. The client is faced with the even more difficult task of making
significant health-related decisions about an event which may or may not eventuate. Although there is a large corpus of research
on this topic, much of the knowledge on risk communication is difficult to apply in a practical context. In this paper we
draw together some insights on risk communication and decision-making under conditions of uncertainty, and apply them directly
to the problem of communicating familial cancer risk. In particular, we focus on the distinction between individual risk and
observed frequencies of adverse events, various framing effects, and contextualizing risk communication. We draw attention
to some of the potential pitfalls in counseling about risk and offer avenues for circumventing them. 相似文献
Previous studies examining the covariation among Attention Deficit Hyperactivity Disorder (ADHD), Oppositional Defiant Disorder
(ODD) and Conduct Disorder (CD) have yielded inconsistent results. Some studies have concluded that the covariation among
these symptoms is due to common genetic influences, whereas others have found a common environmental overlap. The present
study investigated the genetic and environmental correlations among these three childhood disorders, based on a sample of
1,219 twins, age 9–10 years. A latent externalizing behavior factor was found to explain the covariance among ADHD, ODD and
CD symptoms. Genetic influences explained more than half of the variance in this externalizing factor in both boys and girls.
There were also unique genetic and environmental influences in each set of symptoms, suggesting some etiological independence
of the three disorders. Our findings have implications for molecular genetic studies trying to identify susceptibility genes
for these disorders.
This study was funded by NIMH (R01 MH58354). Catherine Tuvblad was supported by post-doctoral stipends from the Swedish Council
for Working Life and Social Research (Project 2006-1501) and the Sweden-America Foundation. Adrian Raine was supported by
NIMH (Independent Scientist Award K02 MH01114-08). We thank the Southern California Twin Project staff for their assistance
in collecting data, and the twins and their families for their participation. 相似文献
This report used a population-representative longitudinal twin study with two birth cohorts to explore the association between intelligence and education by understanding how genetic and environmental influences on intelligence moderate genetic and environmental influences on school grades and educational attainment. Nonshared environmental influences on grades were strong when IQ was low, but decreased across the range of IQ. Shared environmental influences common to age 24 educational attainment and age 17 IQ were strong when IQ was low, but genetic influences common to IQ and education were strong when IQ was high. These results suggest that the causal mechanisms linking educational variables with intelligence differ for people with different levels of intelligence. 相似文献