面对21世纪的人类“圣餐” 中国该怎样分享

人类基因组计划（ＨｕｍａｎＧｅｎｏｍｅＰｒｏｊｅｃｔ,ＨＧＰ）实施７年来已取得巨大进展,不断涌现的新技术、新策略使人基因组全长测序有望在今后几年内提前完成,结构基因组学时代正向功能基因组学时代过渡。然而,发达国家之间的基因争夺战亦愈演愈烈,中国现正面临着严峻挑战。本文简要介绍了ＨＧＰ研究的国际背景、最新进展及发展趋势,目的在于分析目前我国ＨＧＰ研究所存在的问题和探讨其发展对策     

基因芯片技术的出现及对生命科学发展的影响

对于复杂的生命系统,基因芯片技术以一种综合、全面、系统的观点来研究生命现象,打破了以往“一种疾病一个基因”的研究模式,它充分利用了生命科学、信息学等当今带头科学的成果,已成为后基因组时代生命科学研究强有力的工具。随着基因芯片技术的出现, 白质芯片等类似新技术也相继发明,生命科学研究的思维方式正经历一场深刻的改革,同时加速了生物信息、基因工业时代的到来。     

Response to commentaries on discussion paper Gene–environment interdependence

There is a high measure of agreement on the key issues concerning gene–environment interdependence. Contrary to arguments on the need for direct exact replication of findings, it is suggested that “robust” replication using the same constructs is needed. RCTs have an important role for testing for environmental mediation but cannot be used for environmental risks in childhood that show G×E in relation to adult outcomes. Instead, greater use needs to be made of natural experiments. Experimental methods are needed to study biological mediating mechanisms and these should include both animal models and human brain imaging studies. In addition to further research on G×E, further studies of gene–environment correlations are required. Many challenges remain but the future for gene–environment interdependence is bright.     

Contributions of parents and peers to children's moral socialization

This article is concerned with the process of moral development, or specifically, how children acquire a sense of right and wrong from their interactions with two major agents of socialization—parents and peers. The first section of the paper critically examines the literature on parental influences and draws several conclusions about the ways in which parents affect children's moral character. The focus then shifts to a review of the literature on peer group contributions to moral socialization. The paper concludes by examining the literature on cross-pressures, and offering a perspective on the ways in which parental and peer group influences combine to affect children's moral development.     

肿瘤基因治疗的评析

基于用正常基因通过截体纠正、补充缺失或异常基因的原理而进行的肿瘤基因疗法无疑在从根本上治愈肿瘤方面具有诱人的前景。但同时，基础医学研究的薄弱却制约着其进一步推广。认识到其优化非优性，我们就应当努力让其尽快瞳上一条理性化的道路。     

Revising,Correcting, and Transferring Genes

Abstract

The distinction between germline and somatic gene editing is fundamental to the ethics of human gene editing. Multiple conferences of scientists, ethicists, and policymakers, and multiple professional bodies, have called for moratoria on germline gene editing, and editing of human germline cells is considered to be an ethical “red line” that either never should be crossed, or should only be crossed with great caution and care. However, as research on germline gene editing has progressed, it has become clear that not all germline interventions are alike, and that these differences make a significant moral difference, when it comes to ethical questions about research, regulation, clinical application, and medical justification. In this paper, I argue that, rather than lumping all germline interventions together, we should distinguish between revising, correcting, and transferring genes, and I assess the consequences of this move for the ethics of gene editing.