Exploring cortical activation and connectivity in infants with and without familial risk for autism during naturalistic social interactions: A preliminary study

Behavioral signs of Autism Spectrum Disorder (ASD) are typically observable by the second year of life and a reliable diagnosis of ASD is possible by 2 to 3 years of age. Studying infants with familial risk for ASD allows for the investigation of early signs of ASD risk within the first year. Brain abnormalities such as hyper-connectivity within the first year may precede the overt signs of ASD that emerge later in life. In this preliminary study, we use functional near-infrared spectroscopy (fNIRS), an infant-friendly neuroimaging tool that is relatively robust against motion artifacts, to examine functional activation and connectivity during naturalistic social interactions in 9 high-risk (HR; older sibling with ASD) and 6 low-risk (LR; no family history of ASD) infants from 6 to 9 months of age. We obtained two 30-second baseline periods and a 5-minute social interaction period. HR infants showed reduced right and left-hemispheric activation compared to LR infants based on oxy (HbO₂) and deoxy (HHb) signal trends. HR infants also had greater functional connectivity than LR infants during the pre- and post-social periods and showed a drop in connectivity during the social period. Our findings are consistent with previous work suggesting early differences in cortical activation associated with familial risk for ASD, and highlight the promise of fNIRS in evaluating potential markers of ASD risk during naturalistic social contexts.     

A high-field functional MRI study of quadri-lingual subjects

We assessed six multilingual subjects by functional MRI using a Noun Verb Generation task in four different languages. We hypothesised that the degree of proficiency in each language would be related to the extent of functional activity measured in a region of interest analysis. Proficiency in each language was quantified using two neuropsychological tests. All four languages activated overlapping brain areas, corresponding to the major language regions. The number of activated voxels correlated with proficiency, so that the activated volume increased for languages in which a subject had poorer proficiency. Activation did not appear to be dependent on the age at which the language was learnt.     

A positron emission tomography study of short- and long-term treatment effects on functional brain activation in adults who stutter

Previous studies have shown that fluency-inducing techniques, such as choral speech, result in changes in neural activation as measured by functional neuroimaging. In the present study, positron emission tomography was used to investigate the effects of intensive behavioural treatment, followed by a 1-year maintenance program, on the pattern of cortical and subcortical activation in stuttering adults during silent and oral reading of single words. The results indicate changes in activation lateralisation, as well as a general reduction in overactivation, especially in the motor cortex, following treatment. The results are discussed in light of previous functional imaging studies with stuttering adults.

Educational objectives: The reader will learn about and be able to describe the: (1) use of functional neuroimaging PET in the study of stuttering; (2) differences in neural activation between stuttering and non-stuttering adults; and (3) effects of behavioural fluency treatment on cortical and subcortical activations in stuttering speakers.     

Functional learning among children, adolescents, and young adults

This study examined age-related differences in functional learning performance manifested among children, adolescents, and young adults placed in a two-cue ecology involving cues with direct relation and inverse relations with the criterion. On each trial, participants were instructed to consider the values taken by two cues, predict from these two values the value of a criterion, and finally examine the corresponding feedback value (i.e., the correct value of the criterion for this situation). The authors' hypotheses were that: (a) very few children under 11 years of age would be able to learn how to use the inverse relation cue for predicting the criterion, although they would be able to correctly use the direct relation cue; (b) most adolescents and young adults over 17 years of age would be able to learn how to use the inverse relation cue and combine it with the direct relation cue; and (c) adolescents between 11 and 17 years of age would show various levels of achievement. In general, these predictions were confirmed. Not until 11 years was a substantial proportion of participants (23%) able to reject the direct relation hypothesis and select the inverse relation hypothesis during learning.     

Intuitive physics and cognitive algebra: A review

IntroductionIntuitive physics explores how people without a formal instruction in physics intuitively understand physical phenomena. After a general overview of the topics of current research in intuitive physics and a discussion of current debates, this paper provides an introduction to Information Integration Theory (IIT).ObjectiveBy means of examples, it is shown how IIT can be used to directly compare the algebraic structure of physical laws and the algebraic structure of cognitive representations of these laws.MethodThe review considers about 40 years of research on the application of IIT in the field of intuitive physics. Occasionally, reference is also made to intuitive physics studies outside this theoretical framework.ResultsThe reviewed studies highlight four main factors that affect the degree of consistency between physical laws and cognitive algebraic laws: the participants’ age, their familiarity with the event under study, the type of task, and possible learning processes.ConclusionThe last part of the article discusses the implications of the results of the reviewed studies for the two main current hypotheses on the nature of intuitive physics, namely, that intuitive physics may be based on sub-optimal heuristics or may be based on the internalization of physical laws.     

The acceptability of prophylactic mastectomy among lay people and health professionals: A pilot study

IntroductionWomen with certain genetic mutations have a risk of up to 85% of developing breast cancer. Bilateral prophylactic mastectomy is the most effective way to reduce risk of cancer.ObjectiveThis pilot study focuses on the acceptability of prophylactic breast surgery and examines, in a series of concrete cases, the cognitive processes by which health professionals and lay people make their judgments. This research also aims to identify the factors involved in these judgments. An additional objective is to determine whether there are groups with different patterns of responses.MethodWe recruited two samples in France, one comprising 90 lay people and the other 30 health professionals (n = 120) and asked them how acceptable it would be for a woman at a high risk of breast cancer to undergo a prophylactic surgery (mastectomy), in each of the 64 scenarios presented to them. The scenarios were all combinations of two levels of age, of marital status, of parenting status, of body appearance investment, of reconstructive surgery and also two levels of the person suggesting oncogenetic diagnosis.ResultsWe found that lay people and health professionals structured the factors in the scenarios in nearly the same way. They assigned importance to three factors: the most important one was reconstructive surgery, and then the age of the woman. The least important factor was the person who requested the genetic test. Furthermore, the age of the participants, and knowing a person who had cancer impacted the degree of acceptability assigned by participants. Being a lay person or a health professional did not have a direct impact on acceptability but influenced the integration of factors. In addition, cluster analysis showed that only a small group was opposed to mastectomy.ConclusionThis pilot study demonstrated that three factors have to be considered when judging the acceptability of prophylactic mastectomy and showed a common cognitive foundation for future discussion, at the levels of both clinical care and health policy, of the conditions under which prophylactic surgery might be acceptable.     

The relations between specific measures of simulated driving ability and functional ability: New insights for assessment and training programs of older drivers

To gain new insights for driving assessment and training, this study had two objectives: (1) to investigate the relations between specific measures of older drivers’ driving ability and demographic/functional ability measures, and (2) to verify the explained variance of these relations to determine the strength of these relations. A sample of 55 older drivers (mean age 76 years) completed a set of functional ability tests as well as a driving simulator test. Results indicate that (1) each specific driving measure is related to a specific set of functional abilities, and (2) only a small proportion of the variability observed in the specific driving measures is explained by demographic variables (3–15%) and by functional abilities (7–36%). For driving assessment programs, it will be necessary to assess several functional abilities to cover the complexity of the driving task. Furthermore, an assessment program focusing solely on demographic and/or functional ability measures, will not be successful in discriminating safe from unsafe older drivers. For driving training programs, it will be necessary to focus on the right set of functional abilities given that specific driving measures are related to different functional abilities. Moreover, a training targeting functional abilities might only have marginal effects on driving ability, given the relatively low amount of driving ability variance that is explained by functional abilities.     

The functional‐cognitive framework for psychological research: Controversies and resolutions

The scientific goals, values and assumptions of functional and cognitive researchers have propelled them down two very different scientific pathways. Many have, and continue to argue, that these differences undermine any potential communication and collaboration between the two traditions. We explore a different view on this debate. Specifically, we focus on the Functional‐Cognitive (FC) framework, and in particular, the idea that cognitive and functional researchers can and should interact to the benefit of both. Our article begins with a short introduction to the FC framework. We sweep aside misconceptions about the framework, present the original version as it was outlined by De Houwer (2011) and then offer our most recent thoughts on how it should be implemented. Thereafter, we reflect on its strengths and weaknesses, clarify the functional (effect‐centric vs. analytic‐abstractive) level and consider its many implications for cognitive research and theorising. In the final section, we briefly review the articles contained in this Special Issue. These contributions provide clear examples of the conceptual, empirical and methodological developments that can emerge when cognitive, clinical, personality and neuroscientists fully engage with the functional‐cognitive perspective.