Cognitive and emotional processes during dreaming: a neuroimaging view

Dream is a state of consciousness characterized by internally-generated sensory, cognitive and emotional experiences occurring during sleep. Dream reports tend to be particularly abundant, with complex, emotional, and perceptually vivid experiences after awakenings from rapid eye movement (REM) sleep. This is why our current knowledge of the cerebral correlates of dreaming, mainly derives from studies of REM sleep. Neuroimaging results show that REM sleep is characterized by a specific pattern of regional brain activity. We demonstrate that this heterogeneous distribution of brain activity during sleep explains many typical features in dreams. Reciprocally, specific dream characteristics suggest the activation of selective brain regions during sleep. Such an integration of neuroimaging data of human sleep, mental imagery, and the content of dreams is critical for current models of dreaming; it also provides neurobiological support for an implication of sleep and dreaming in some important functions such as emotional regulation.     

The temporal organization of functional brain connectivity is abnormal in schizophrenia but does not correlate with symptomatology

Previous work employing graph theory and nonlinear analysis has found increased spatial and temporal disorder, respectively, of functional brain connectivity in schizophrenia. We present a new method combining graph theory and nonlinear techniques that measures the temporal disorder of functional brain connections. Multichannel electroencephalographic data were windowed and functional networks were reconstructed using the minimum spanning trees of correlation matrices. Using a method based on Shannon entropy, we found elevated connection entropy in gamma activity of patients with schizophrenia; however, gamma connection entropy remained elevated in patients with schizophrenia even after a reduction in symptoms due to treatment with antipsychotics. Our results are consistent with several possibilities: (1) aberrant functional connectivity is epiphenomenal to schizophrenia, (2) aberrant functional connectivity is a central feature but antipsychotics reduce symptoms by an independent mechanism, or (3) connection entropy is not an appropriately sensitive measure of brain abnormalities in schizophrenia.     

Perception of suffering and compassion experience: brain gender disparities

Compassion is considered a moral emotion related to the perception of suffering in others, and resulting in a motivation to alleviate the afflicted party. We compared brain correlates of compassion-evoking images in women and men. BOLD functional images of 24 healthy volunteers (twelve women and twelve men; age=27±2.5 y.o.) were acquired in a 3T magnetic resonance scanner while subjects viewed pictures of human suffering previously verified to elicit compassion and indicated their compassionate experience by finger movements. Functional analysis revealed that while women manifested activation in areas involved in basic emotional, empathic, and moral processes, such as basal regions and cingulate and frontal cortices, activation in men was restricted mainly to the occipital cortex and parahippocampal gyrus. These findings suggest that compassion and its moral elements constitute gender-relative subjective phenomena emerging from differently evolved neural mechanisms and socially learned features possibly related to nurturing skills.     

Attentional modulation of perceptual comparison for feature binding

We investigated the neural correlates of attentional modulation in the perceptual comparison process for detecting feature-binding changes in an event-related functional magnetic resonance imaging (fMRI) experiment. Participants performed a variant of a cued change detection task. They viewed a memory array, a spatial retro-cue, and later a probe array. Their task was to judge whether the cued item had changed between the two arrays. Change type was manipulated to be a color-location binding or a color feature change. The retro-cue onset time in the retention interval was manipulated to be early or late. As a consequence of strong inter-item competition, we found strong prefrontal activation for late cues when contrasting the binding-change with the color-change condition. In contrast, we observed a comparable behavioral and neural effect between the two types of change detection when retro-cue was presented early. More importantly, we demonstrated a significant inter-regional correlation between the prefrontal and parietal regions in both binding- and color-change conditions for late cues. In addition, extensive prefrontal-parietal-visual functional connectivity was showed for detecting binding changes in the late-cueing condition. These results support the critical role in prefrontal-parietal-visual functional coupling for resolving strong inter-item competition during the comparison process in the binding-change condition. We provide direct evidence that attention modulates neural activity associated with perceptual comparison, biasing competition in favour of the task-relevant information in order to detect binding changes.     

Cognitive control of a simple mental image in patients with obsessive--compulsive disorder

The nature of obsessions has led researchers to try to determine if the main problem in obsessive-compulsive disorder (OCD) is impaired inhibitory control. Previous studies report that the effort to suppress is one of the factors that increase the frequency of obsessive thoughts. Based on these results and those of the present study that suggest inferior parietal lobe (IPL) abnormality in OCD and findings of a recent study that reported the importance of the right posterior parietal cortex in cognitive control of a simple mental image, the present cognitive control paradigm study aimed to determine whether there is a difference in brain dynamics between OCD patients and non-obsessive controls while performing tasks that necessitate cognitive control of a simple mental image, and whether the right posterior parietal region is one of the regions in which a difference in activity between the OCD patients and controls would be observed. Functional brain imaging was performed while the participants attempted to suppress, imagine, or manipulate a mental image. The general linear model showed that there was a main effect of group and main effect of task. Accordingly, in all contrasts (suppression minus free-imagination, erasing minus free-imagination, and imagination minus free-imagination), the right IPL, right posterior cingulate cortex, and right superior frontal gyrus activity were lower in the OCD patients than in the healthy controls. These results and the observed correlations between activity levels, and symptom and subjective performance scores are discussed. In conclusion, the results of the present study and those of previous studies suggest that the main problem in OCD might be difficulty activating the right frontoparietal networks during tasks that require cognitive control, which might result in the intrusiveness of obsessive thoughts.     

Reduction and emergence in the physical sciences: Reply to Rueger

I analyse Rueger’s application of Kim’s model of functional reduction to the relation between the thermal conductivities of metal bars at macroscopic and atomic scales. 1) I show that it is a misunderstanding to accuse the functional reduction model of not accounting for the fact that there are causal powers at the micro-level which have no equivalent at the macro-level. The model not only allows but requires that the causal powers by virtue of which a functional predicate is defined, are only a subset of the causal powers of the properties filling the functional specification. 2) The fact that the micro-equation does not converge to the macro-equation in general but only under the constraint of a “solvability condition” does not show that reduction is impossible, as Rueger claims, but only that reduction requires inter-level constraints. 3) Rueger tries to analyse inter-level reduction with the conceptual means of intra-level reduction. This threatens the coherence of his analysis, given that it makes no sense to ascribe macroproperties such as thermal conductivity to entities at the atomic level. Ignoring the distinction between theses two senses of “reduction” is especially confusing because they have opposite directions: in intra-level reduction, the more detailed account reduces to the less detailed one, whereas in inter-level reduction, the less detailed theory is reduced to the more detailed one. 4) Finally I criticize Rueger’s way of using Wimsatt’s criteria for emergence in terms of non-aggregativity, to construct a concept of synchronic emergence. It is wrong to require, over and above non-aggregativity, irreducibility as a criterion for emergence.     

Analytical methods in the theory of psychophysical discrimination II: The Near-miss to Weber's Law, Falmagne's Law, the Psychophysical Power Law and the Law of Similarity

We examine the possibility of accounting for an empirical phenomenon in auditory psychophysics called the “Near-Miss to Weber's Law” [Jesteadt, W., Weir, C., & Green, D. (1977). Intensity discrimination as a function of frequency and sensation level. Journal of the Acoustical Society of America, A, 61, 169-177], within the framework of Fechner's Psychophysics. To this end, we introduce a pair of Psychophysical Laws governing the behavior of Weber sensitivities. One of these, the Power Law, embodies ideas that Jesteadt et al. introduced in their original discussion of the near-miss phenomenon. Falmagne's Law captures ideas of Falmagne and colleagues [Falmagne, J.-Cl. (1985). Elements of psychophysical theory. New York: Oxford University Press; Doble, C., Falmagne, J.-Cl., & Berg, B.G. (2003). Theoretical note: Recasting (the near-miss to) Weber's Law. Psychological Review, 110, 365-375]. These two laws, which account for the near-miss phenomenon in quite different ways, are shown to be special cases of a more general Psychophysical Law of Similarity. We find all (smooth) solutions of this Law of Similarity that are compatible with Fechnerian psychophysics. Of the 11 solutions, four are relevant to the near-miss phenomenon; two of these solutions reproduce the models of Jesteadt et al. and Doble et al. and the other two solutions each provide a new accounting of the near-miss phenomenon. We discuss the possibility of distinguishing among these four models in empirical data.     

A Functional Analysis of 2004 Ukrainian Presidential Debates

Political leaders’ debates are an important and highly visible instances of public argumentation. As such, they merit scholarly attention. This essay applies the Functional Theory of Political Campaign Discourse to analyze televised presidential debates from the Ukraine in 2004. Overall, this analysis revealed that acclaims were the most common function, followed by attacks and then defenses. Policy was addressed more often than character in these debates, as expected. The incumbent candidate acclaimed significantly more and attacked less than the challenger. The incumbents used past deeds significantly more often to acclaim – and less to attack – than the challengers. Finally, general goals and ideals were used more as the basis for acclaims than attacks in these debates. Implications of these results are discussed.     

Physicians’ gender bias in the diagnostic assessment of medically unexplained symptoms and its effect on patient–physician relations

Nonspecific, functional, and somatoform (NFS) syndromes is an umbrella term for various diagnoses with medically unexplained symptoms. These syndromes are more prevalent among women than among men, and associated with negative preconceptions that can impede rehabilitation. In two studies, we quantitatively assess how patients’ gender affects the diagnostic assessment of NFS syndromes, as well as the healthcare experiences of individuals diagnosed with NFS syndromes. In the first study, our vignette‐based experiment showed that Swedish general practitioners (N = 90) were gender biased in their diagnostic assessment of NFS syndromes, such that a female patient with back pain was more likely to be assigned a NFS syndrome compared to an otherwise identical male patient. In the second study, a large community sample of Swedish individuals with medically explained (n = 432) and unexplained pain (n = 521) evaluated their treating physician's relational conduct. Even after accounting for a variety of sociodemographic variables and other pain characteristics, women with at least one NFS syndrome percieved their physician's relational conduct as significantly poorer than other women as well as men with and without NFS syndromes. When women's pain is more likely than men's to be assessed as NFS, their rehabilitation could be prolonged as pertient alternative diagnoses and treatments are omittied and their negative healthcare experiences lower their volition to partake and persevere in treatment.     

An outcome evaluation of Functional Family Therapy for court‐involved youth

This article presents results of a study on the effectiveness of Functional Family Therapy (FFT), a family intervention designed to prevent delinquency. The sample includes 155 court‐involved youth. This study employs two complementary outcomes: court‐obtained data on recidivism and the clinical data on clients’ psychosocial functioning, the Strengths and Needs Assessment (SNA). Adolescents in the treatment and in the comparison groups experienced statistically significant improvements on the majority of the SNA domains. Although youths in the treatment group improved more, the differences between the groups were not statistically significant. Multivariate analysis showed that youths in FFT had significantly lower odds of recidivism as measured by reconvictions for drug offenses, property offenses and technical violations. The results suggest that FFT was effective in reducing recidivism, however, such reductions cannot be attributed to improvements in the SNA scores.