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141.
142.
Right brain damaged patients sometimes deny that their left arm is paralysed or even claim to have just moved it. This condition is known as anosognosia for hemiplegia (AHP). Here, we used fMRI to study patients with and without AHP during the execution of a motor task. We found that the delusional belief of having moved was preceded by brain activation of the cortical regions that are implicated in motor control in the left intact hemisphere and in the spared motor regions of the right hemisphere; patients without anosognosia did not present with the same degree of activation. We conclude that the false belief of movement is associated with a combination of strategically placed brain lesions and the preceding residual neural activity of the fronto-parietal motor network. These findings provide evidence that the activity of motor cortices contributes to our beliefs about the state of our motor system. 相似文献
143.
Tomanari GY Sidman M Rubio AR Dube WV 《Journal of the experimental analysis of behavior》2006,85(3):349-369
Five adult humans were tested for emergent conditional discriminations under rapid-responding contingencies. During four-comparison matching-to-sample baseline training (AB and AC), limited-hold contingencies for responding to samples and comparisons were gradually restricted to the shortest duration consistent with at least 95% accuracy and no more than 5% failures to respond. The final limited-hold values were 0.4-0.5 s for samples and 1.2-1.3 s for comparisons; mean response latencies were 0.15-0.28 s for samples and 0.59-0.73 s for comparisons; inter-trial intervals were 0.4 s. With these fast-responding requirements, test blocks presented 72 probe trials interspersed among 72 baseline trials, all without programmed differential consequences. Four equivalence test blocks (BC and CB probes, which tested simultaneously for both symmetry and transitivity) were followed by four symmetry (BA and CA probes) test blocks. Three subjects' results documented emergent performances indicative of equivalence classes despite fast-responding requirements that severely limited the time available for mediating vocal or subvocal responses. For these three subjects, mean latencies were slightly shorter in baseline trials than in probes, and shorter on symmetry than on equivalence probes. These differences, however, were usually less than the differences among mean latencies on the different types of trials within the baseline and probed performances. 相似文献
144.
Neural localization of semantic context effects in electromagnetic and hemodynamic studies 总被引:5,自引:0,他引:5
Measures of electrical brain activity (event-related potentials, ERPs) have been useful in understanding language processing for several decades. Extant data suggest that the amplitude of the N400 component of the ERP is a general index of the ease or difficulty of retrieving stored conceptual knowledge associated with a word, which is dependent on both the stored representation itself, and the retrieval cues provided by the preceding context. Recordings from patients with brain damage, intracranial recordings, and magnetoencephalographic data implicate a (probably large portion of) the left temporal lobe as the largest source of the N400 semantic context effect, with a substantial but lesser contribution from the right temporal lobe. Event-related functional magnetic resonance (fMRI) studies using semantic context manipulations are dominated by observations of greater hemodynamic activity for incongruent sentence completions or semantically unrelated words than congruent or related words, consistent with the direction of the ERP effect. The locations of the hemodynamic effects show some variability across studies, but one commonly identified region is the left superior temporal gyrus, which is compatible with the electrophysiological results. A second commonly identified region in the fMRI studies is the left inferior frontal gyrus, which does not appear to make a substantial contribution to the N400 effect. 相似文献
145.
The Wada test is at present the method of choice for preoperative assessment of patients who require surgery close to cortical language areas. It is, however, an invasive test with an attached morbidity risk. By now, an alternative to the Wada test is to combine a lexical word generation paradigm with non-invasive imaging techniques. However, results of this approach are still not in complete agreement with the findings of the Wada test (r = .92; Knecht, Deppe, Ebner et al., 1998). We attempted to obtain a more distinct language lateralization with the development of a phonological rhyme generation paradigm based on pseudoword stimuli. To examine the predictive value of both paradigms we performed simultaneous bilateral functional transcranial Doppler ultrasonography on 19 right-handed male native German subjects. The rhyme generation condition produced a significantly stronger lateralization to the supposed hemisphere of language dominance than the classical word generation condition. The observed differences suggest that the rhyme generation paradigm is more robust in detecting hemispheric language dominance than other neuropsychological paradigms and might be most valuable for preoperative assessment of cortical language areas. 相似文献
146.
Van Lancker Sidtis D 《Brain and language》2006,98(3):276-290
Neurolinguistic research has been engaged in evaluating models of language using measures from brain structure and function, and/or in investigating brain structure and function with respect to language representation using proposed models of language. While the aphasiological strategy, which classifies aphasias based on performance modality and a few linguistic variables, has been the most stable, cognitive neurolinguistics has had less success in reliably associating more elaborately proposed levels and units of language models with brain structure. Functional imaging emerged at this stage of neurolinguistic research. In this review article, it is proposed that the often-inconsistent superfluity of outcomes arising from functional imaging studies of language awaits adjustment at both "ends" of the process: model and data. Assumptions that our current language models consistently and reliably represent implicit knowledge within human cerebral processing are in line for major revision; and the promise of functional brain imaging to reveal any such knowledge structures must incorporate stable correlates of the imaging signal as dependent variable. 相似文献
147.
Fields L Matneja P Varelas A Belanich J Fitzer A Shamoun K 《Journal of the experimental analysis of behavior》2002,78(3):271-290
Multiple-exemplar training with stimuli in four domains induced two new fill-based (A1' and A2') and satellite-image-based (B1' and B2') perceptual classes. Conditional discriminations were established between the endpoints of the A1' and B1' classes as well as the A2' and B2' classes. The emergence of linked perceptual classes was evaluated by the performances occasioned by nine cross-class probes that contained fill variants as samples and satellite variants as comparisons, along with nine other cross-class probes that consisted of satellite variants as samples and fill variants as comparisons. The 18 probes were first presented serially and then concurrently. Class-consistent responding indicated the emergence of linked perceptual classes. Of the linked perceptual classes, 70% emerged during the initial serial test. An additional 20% of the linked perceptual classes emerged during the subsequently presented concurrent test block. Thus, linked perceptual classes emerged on an immediate or delayed basis. Linked perceptual classes, then, share structural and fuctional similarities with equivalence classes, generalized equivalence classes, cross-modal classes, and complex maturally occurring categories, and may clarify processes such as intersensory perception. 相似文献
148.
Stewart I Barnes-Holmes D Roche B Smeets PM 《Journal of the experimental analysis of behavior》2002,78(3):375-396
The aim of this study was to explore a behavior-analytic model of analogical reasoning, defined as the discrimination of formal similarity via equivalence-equivalence responding. In Experiment 1, adult humans were trained and tested for the formation of four three-member equivalence relations: A1-B1-C1, A2-B2-C2, A3-B3-C3, and A4-B4-C4. The B and C stimuli were three-letter nonsense syllables, and the A stimulus was a colored shape. Subjects were then successfully tested for equivalence-equivalence responding (e.g., matching B1/C1 to B2/C2 rather than B3/C4). These tasks were designed such that equivalence-equivalence responding might allow subjects to discriminate a physical similarity between the relations involved. Some participants (color subjects) received only equivalence-equivalence tasks in which they might discriminate a color relation, whereas others (shape subjects) were given tasks in which they might discriminate a shape relation. A control group received both types of task. In a subsequent test for the discrimination of formal similarity, color subjects matched according to color, shape subjects matched according to shape, and the control group showed no consistent matching pattern. In Experiment 2, adult humans showed a transformation of the functions of a block-sorting task via this basic model of analogy. Empirical and conceptual issues related to these results are discussed. 相似文献
149.
Urcuioli PJ Pierce JN Lionello-DeNolf KM Friedrich A Fetterman JG Green C 《Journal of the experimental analysis of behavior》2002,78(3):409-432
Three experiments attempted to replicate Manabe, Kawashima, and Staddon's (1995) finding of emergent differential sample behavior in budgerigars that has been interpreted as evidence of functional equivalence class formation. In Experiments 1 and 2, pigeons initially learned two-sample/ two-alternative matching to sample in which comparison presentation was contingent on pecking one sample on a differential-reinforcement-of-low-rate (DRL) schedule and the other on a fixed-ratio (FR) schedule. Later, two new samples were added to the task. Comparison presentation on these trials occurred after the first sample peck following a predetermined interval (Experiment 1) or after completion of either the DRL or FR requirement, whichever occurred first (Experiment 2). Experiment 1 found no evidence for emergent spaced versus rapid responding to the new samples as they established conditional control over the familiar choices. By contrast, differential responding did emerge for some pigeons in Experiment 2, with responding to each new sample coinciding with the pattern explicitly conditioned to the original sample occasioning the same comparison choice. This emergent effect, however, disappeared for most pigeons with continued training. Experiment 3 systematically replicated Experiment 2 using differential peck location as the sample behavior. Differential location pecking emerged to the new samples for most pigeons and remained intact throughout training. Our findings demonstrate a viable pigeon analogue to the budgerigar emergent calling paradigm and are discussed in terms of equivalence- and non-equivalence-based processes. 相似文献
150.