A high-field functional MRI study of quadri-lingual subjects

We assessed six multilingual subjects by functional MRI using a Noun Verb Generation task in four different languages. We hypothesised that the degree of proficiency in each language would be related to the extent of functional activity measured in a region of interest analysis. Proficiency in each language was quantified using two neuropsychological tests. All four languages activated overlapping brain areas, corresponding to the major language regions. The number of activated voxels correlated with proficiency, so that the activated volume increased for languages in which a subject had poorer proficiency. Activation did not appear to be dependent on the age at which the language was learnt.     

A positron emission tomography study of short- and long-term treatment effects on functional brain activation in adults who stutter

Previous studies have shown that fluency-inducing techniques, such as choral speech, result in changes in neural activation as measured by functional neuroimaging. In the present study, positron emission tomography was used to investigate the effects of intensive behavioural treatment, followed by a 1-year maintenance program, on the pattern of cortical and subcortical activation in stuttering adults during silent and oral reading of single words. The results indicate changes in activation lateralisation, as well as a general reduction in overactivation, especially in the motor cortex, following treatment. The results are discussed in light of previous functional imaging studies with stuttering adults.

Educational objectives: The reader will learn about and be able to describe the: (1) use of functional neuroimaging PET in the study of stuttering; (2) differences in neural activation between stuttering and non-stuttering adults; and (3) effects of behavioural fluency treatment on cortical and subcortical activations in stuttering speakers.     

Functional learning among children, adolescents, and young adults

This study examined age-related differences in functional learning performance manifested among children, adolescents, and young adults placed in a two-cue ecology involving cues with direct relation and inverse relations with the criterion. On each trial, participants were instructed to consider the values taken by two cues, predict from these two values the value of a criterion, and finally examine the corresponding feedback value (i.e., the correct value of the criterion for this situation). The authors' hypotheses were that: (a) very few children under 11 years of age would be able to learn how to use the inverse relation cue for predicting the criterion, although they would be able to correctly use the direct relation cue; (b) most adolescents and young adults over 17 years of age would be able to learn how to use the inverse relation cue and combine it with the direct relation cue; and (c) adolescents between 11 and 17 years of age would show various levels of achievement. In general, these predictions were confirmed. Not until 11 years was a substantial proportion of participants (23%) able to reject the direct relation hypothesis and select the inverse relation hypothesis during learning.     

Intuitive physics and cognitive algebra: A review

IntroductionIntuitive physics explores how people without a formal instruction in physics intuitively understand physical phenomena. After a general overview of the topics of current research in intuitive physics and a discussion of current debates, this paper provides an introduction to Information Integration Theory (IIT).ObjectiveBy means of examples, it is shown how IIT can be used to directly compare the algebraic structure of physical laws and the algebraic structure of cognitive representations of these laws.MethodThe review considers about 40 years of research on the application of IIT in the field of intuitive physics. Occasionally, reference is also made to intuitive physics studies outside this theoretical framework.ResultsThe reviewed studies highlight four main factors that affect the degree of consistency between physical laws and cognitive algebraic laws: the participants’ age, their familiarity with the event under study, the type of task, and possible learning processes.ConclusionThe last part of the article discusses the implications of the results of the reviewed studies for the two main current hypotheses on the nature of intuitive physics, namely, that intuitive physics may be based on sub-optimal heuristics or may be based on the internalization of physical laws.     

The acceptability of prophylactic mastectomy among lay people and health professionals: A pilot study

IntroductionWomen with certain genetic mutations have a risk of up to 85% of developing breast cancer. Bilateral prophylactic mastectomy is the most effective way to reduce risk of cancer.ObjectiveThis pilot study focuses on the acceptability of prophylactic breast surgery and examines, in a series of concrete cases, the cognitive processes by which health professionals and lay people make their judgments. This research also aims to identify the factors involved in these judgments. An additional objective is to determine whether there are groups with different patterns of responses.MethodWe recruited two samples in France, one comprising 90 lay people and the other 30 health professionals (n = 120) and asked them how acceptable it would be for a woman at a high risk of breast cancer to undergo a prophylactic surgery (mastectomy), in each of the 64 scenarios presented to them. The scenarios were all combinations of two levels of age, of marital status, of parenting status, of body appearance investment, of reconstructive surgery and also two levels of the person suggesting oncogenetic diagnosis.ResultsWe found that lay people and health professionals structured the factors in the scenarios in nearly the same way. They assigned importance to three factors: the most important one was reconstructive surgery, and then the age of the woman. The least important factor was the person who requested the genetic test. Furthermore, the age of the participants, and knowing a person who had cancer impacted the degree of acceptability assigned by participants. Being a lay person or a health professional did not have a direct impact on acceptability but influenced the integration of factors. In addition, cluster analysis showed that only a small group was opposed to mastectomy.ConclusionThis pilot study demonstrated that three factors have to be considered when judging the acceptability of prophylactic mastectomy and showed a common cognitive foundation for future discussion, at the levels of both clinical care and health policy, of the conditions under which prophylactic surgery might be acceptable.     

长期戒断海洛因成瘾者冲动性相关脑区的结构及功能特征

冲动性是药物成瘾者的典型特征, 它既包含了抑制控制成瘾者药物使用的力量, 也包含驱动成瘾者使用药物的成分, 两者不平衡导致冲动性用药行为。海洛因成瘾者本身具有冲动性人格特质, 长时间的海洛因使用又会造成成瘾者冲动性相关的大脑结构与功能的异常。目前难以确定戒断后, 冲动性及相关的大脑结构与功能是否还呈异常状态。本研究采用基于体素的形态学分析、低频振幅、局部一致性和功能连接方法, 以35例海洛因成瘾戒断者和无任何成瘾史的健康个体26人为研究对象, 探索在长期戒断后, 海洛因成瘾者与其冲动性相关的驱动、控制系统脑网络的结构和功能情况。结果显示, 相比对照组, 戒断组灰质总体积及右内侧额上回的灰质体积显著减小, 右侧颞中回和左内侧旁扣带回的灰质体积随用药总量的增加而降低; 右侧眶部额下回与尾状核功能连接显著增强, 右侧颞中回和左侧中央前回功能连接显著降低; 右眶额中回的ReHo值、右眶额下回和左海马体的ALFF值比对照组显著更低, 而右中央后回的ReHo值显著更高。这些脑区的状况与冲动性的神经基础相吻合, 说明海洛因成瘾戒断者在戒断44个月, 奖赏、凸显、习惯性行为等网络系统仍然呈现异常状态, 且与成瘾药物使用总量有关。这些异常可能是成瘾冲动性的驱动力的神经基础, 可以作为解释成瘾者戒断后容易复吸的因素之一。     

脑岛在成瘾中的结构和功能异常

脑岛位于大脑外侧裂的深处, 与情绪和内感受等多种心理功能有关。脑岛在成瘾中的结构变化和功能连接异常, 表明了脑岛在成瘾中的作用, 刺激脑岛区域干预成瘾也逐渐成为研究者们关注的领域。未来的研究应该通过对脑岛进行精细分割和多种方法相结合来进一步考察脑岛在成瘾中的具体作用, 并挖掘不同成瘾类型的共性和特性, 以便更好开展基于脑的成瘾干预。     

The multiple realization book

In this review of Thomas W. Polger and Lawrence A. Shapiro’s The Multiple Realization Book I look at the positive account, Modest Identity Theory, that Polger and Shapiro advance. In §2 of this review, I outline P&S’s arguments against multiple realization and summarize the view they defend, Modest Identity Theory. In §3, I consider what consequences the adoption of Modest Identity Theory might have on the ontology of psychological or mental kinds. In particular, I highlight the ontological pluralism and anti-reductionism that Polger and Shapiro endorse. Modest Identity Theory tolerates multiple taxonomies of psychological kinds, which represents an important departure from earlier versions of Identity Theory. I conclude in §4 by arguing that the way Modest Identity Theory individuates psychological kinds very closely resembles the way that those kinds are individuated by functionalism. I argue that the causal properties individuative of psychological kinds can be used to group together distinct neuroanatomical characteristics. I illustrate this by describing research into the functional connectivity of the reading network. I conclude by emphasizing the value of using empirical evidence from neuroscience and cognitive science to inform the new pluralistic ontology of psychological and mental kinds with which Modest Identity Theory is compatible.     

The relations between specific measures of simulated driving ability and functional ability: New insights for assessment and training programs of older drivers

To gain new insights for driving assessment and training, this study had two objectives: (1) to investigate the relations between specific measures of older drivers’ driving ability and demographic/functional ability measures, and (2) to verify the explained variance of these relations to determine the strength of these relations. A sample of 55 older drivers (mean age 76 years) completed a set of functional ability tests as well as a driving simulator test. Results indicate that (1) each specific driving measure is related to a specific set of functional abilities, and (2) only a small proportion of the variability observed in the specific driving measures is explained by demographic variables (3–15%) and by functional abilities (7–36%). For driving assessment programs, it will be necessary to assess several functional abilities to cover the complexity of the driving task. Furthermore, an assessment program focusing solely on demographic and/or functional ability measures, will not be successful in discriminating safe from unsafe older drivers. For driving training programs, it will be necessary to focus on the right set of functional abilities given that specific driving measures are related to different functional abilities. Moreover, a training targeting functional abilities might only have marginal effects on driving ability, given the relatively low amount of driving ability variance that is explained by functional abilities.