Sense of body ownership in patients affected by functional motor symptoms (conversion disorder)

Background and aimPatients with functional neurological symptoms are commonly seen in neurological practice. Nevertheless their aetiopathology remains unclear. We have recently shown that patients affected by functional motor symptoms (FMS) present lower interoceptive awareness and higher alexithymia levels than healthy controls. Nevertheless sense of body ownership has never been studied in FMS patients.The aim of the present study was to systematically investigate the sense of body ownership, with the rubber hand illusion (RHI) paradigm, in patients with FMS and healthy controls.Materials and methodsWe included in the study 16 patients with FMS and 18 healthy controls (HC). Patients and HC were asked to complete the Toronto Alexithymia Scale (TAS-20) and the self-consciousness scale (self-objectification questionnaire). All participants underwent the RHI paradigm: illusionary experience was measured by self-report and by proprioceptive alteration.ResultsA Mann–Whitney U test performed revealed that FMS (median = 2.11) participants embodied the rubber hand to the same extent than HC participants (median = 2.0, Z = −0.86, p > 0.05, r = −0.15). The same test revealed no significant difference in the Proprioceptive Drift experience between FMS (median = 0.0) and HC participants (median = −0.5, Z = −0.96, p > 0.05, r = −0.16).ConclusionsOur study revealed that sense of body ownership is not impaired in patients affected by FMS. This, together with the results from our previous experiment (studying the interoceptive awareness), supports the hypothesis that interoceptive awareness and sense of body ownership may be dissociated in patients with FMS.     

A key role for experimental task performance: effects of math talent, gender and performance on the neural correlates of mental rotation

The neurophysiological mechanisms underlying superior cognitive performance are a research area of high interest. The majority of studies on the brain-performance relationship assessed the effects of capability-related group factors (e.g. talent, gender) on task-related brain activations while only few studies examined the effect of the inherent experimental task performance factor. In this functional MRI study, we combined both approaches and simultaneously assessed the effects of three relatively independent factors on the neurofunctional correlates of mental rotation in same-aged adolescents: math talent (gifted/controls: 17/17), gender (male/female: 16/18) and experimental task performance (median split on accuracy; high/low: 17/17). Better experimental task performance of mathematically gifted vs. control subjects and male vs. female subjects validated the selected paradigm. Activation of the inferior parietal lobule (IPL) was identified as a common effect of mathematical giftedness, gender and experimental task performance. However, multiple linear regression analyses (stepwise) indicated experimental task performance as the only predictor of parietal activations. In conclusion, increased activation of the IPL represents a positive neural correlate of mental rotation performance, irrespective of but consistent with the obtained neurocognitive and behavioral effects of math talent and gender. As experimental performance may strongly affect task-related activations this factor needs to be considered in capability-related group comparison studies on the brain-performance relationship.     

Menstrual cycle-related changes of functional cerebral asymmetries in fine motor coordination

Fluctuating sex hormone levels during the menstrual cycle have been shown to affect functional cerebral asymmetries in cognitive domains. These effects seem to result from the neuromodulatory properties of sex hormones and their metabolites on interhemispheric processing. The present study was carried out to investigate whether functional cerebral asymmetries in fine motor coordination as reflected by manual asymmetries are also susceptible to natural sex hormonal variations during the menstrual cycle. Sixteen right-handed women with a regular menstrual cycle performed a finger tapping paradigm consisting of two conditions (simple, sequential) during the low hormone menstrual phase and the high estrogen and progesterone luteal phase. To validate the luteal phase, saliva levels of free progesterone (P) were analysed using chemiluminescence assays. As expected, normally cycling women showed a substantial decrease in manual asymmetries in a more demanding sequential tapping condition involving four fingers compared with simple (repetitive) finger tapping. This reduction in the degree of dominant (right) hand manual asymmetries was evident during the luteal phase. During the menstrual phase, however, manual asymmetries were even reversed in direction, indicating a slight advantage in favour of the non-dominant (left) hand. These findings suggest that functional cerebral asymmetries in fine motor coordination are affected by sex hormonal changes during the menstrual cycle, probably via hormonal modulations of interhemispheric interaction.     

Endless Qualifications,Restless Consumption: The Governance of Novel Foods in Europe

Functional foods and foods derived from genetically modified organisms represent two forms of intervention in the design of foodstuffs that have given rise to distinct political and regulatory dynamics. In Europe, regulatory agencies have tried, unsuccessfully, to affix a definitive legal meaning to these categories of food artificiality. This incomplete process of legal disambiguation has gone hand in hand with the delegation of the responsibility for overseeing new products to consumers, who are asked to continuously consider and assess the qualities of foods when making their choices in the marketplace. In the case of genetically modified foods, we have witnessed strategies of avoidance premised on the consideration of genetic modification as a blemish on the conventional character of foodstuffs. Functional foods, on the other hand, are increasingly mobilized in practices of naturalistic enhancement. What both examples have in common is the open-ended character of their respective regulatory regimes, and the continuous prodding of consumers to involve themselves more intensely in the weighing of their food choices. The result is a particular mode of market activism that we describe as restless consumption.     

Intrinsic frames of reference in haptic spatial learning

It has been proposed that spatial reference frames with which object locations are specified in memory are intrinsic to a to-be-remembered spatial layout (intrinsic reference theory). Although this theory has been supported by accumulating evidence, it has only been collected from paradigms in which the entire spatial layout was simultaneously visible to observers. The present study was designed to examine the generality of the theory by investigating whether the geometric structure of a spatial layout (bilateral symmetry) influences selection of spatial reference frames when object locations are sequentially learned through haptic exploration. In two experiments, participants learned the spatial layout solely by touch and performed judgments of relative direction among objects using their spatial memories. Results indicated that the geometric structure can provide a spatial cue for establishing reference frames as long as it is accentuated by explicit instructions (Experiment 1) or alignment with an egocentric orientation (Experiment 2). These results are entirely consistent with those from previous studies in which spatial information was encoded through simultaneous viewing of all object locations, suggesting that the intrinsic reference theory is not specific to a type of spatial memory acquired by the particular learning method but instead generalizes to spatial memories learned through a variety of encoding conditions. In particular, the present findings suggest that spatial memories that follow the intrinsic reference theory function equivalently regardless of the modality in which spatial information is encoded.     

Functional magnetic resonance imaging study of Piaget's conservation-of-number task in preschool and school-age children: a neo-Piagetian approach

Jean Piaget’s theory is a central reference point in the study of logico-mathematical development in children. One of the most famous Piagetian tasks is number conservation. Failures and successes in this task reveal two fundamental stages in children’s thinking and judgment, shifting at approximately 7 years of age from visuospatial intuition to number conservation. In the current study, preschool children (nonconservers, 5-6 years of age) and school-age children (conservers, 9-10 years of age) were presented with Piaget’s conservation-of-number task and monitored by functional magnetic resonance imaging (fMRI). The cognitive change allowing children to access conservation was shown to be related to the neural contribution of a bilateral parietofrontal network involved in numerical and executive functions. These fMRI results highlight how the behavioral and cognitive stages Piaget formulated during the 20th century manifest in the brain with age.     

Through the eyes of dieters: Biased size perception of food following tempting food primes

Why do some dieters succeed in controlling their diet while others do not? This research focused on a perceptual process—size perception of food objects—that may moderate the success of dieters in self-control dilemmas. We assessed successful and unsuccessful dieters' size perception of palatable food (Study 1) and diet-food (Study 2) after pre-exposing them to tempting food primes. Dieters perceived palatable food as bigger when primed with tempting food (vs. control prime), regardless of self-regulatory success in dieting (Study 1). Palatable food thus looms larger for both unsuccessful and successful dieters when in a “hot” state. In contrast, the perceived size of diet-food was increased by a tempting food prime only for successful dieters, but decreased for unsuccessful dieters (Study 2). These results are interpreted in terms of differences in the mental accessibility of competing goals (eating enjoyment vs. dieting) in successful vs. unsuccessful dieters. Indeed, when the dieting goal was made accessible for all dieters by a diet prime, even unsuccessful dieters perceived diet-food as bigger (Study 2). This research provides insight into a perceptual process that may be detrimental or beneficial in resolving self-control conflicts in the domain of eating and dieting behavior—and probably other domains of self-control as well.     

Dichotic listening and left-right confusion

The present study examined the relationship between individual differences in dichotic listening (DL) and the susceptibility to left-right confusion (LRC). Thirty-six men and 59 women completed a consonant-vowel DL test, a behavioral LRC task, and an LRC self-rating questionnaire. Significant negative correlations between overall DL accuracy and LRC rates in men (behavioral task) and self-ratings in women, indicated that the more participants struggled with left-right discrimination, the fewer DL syllables they reported correctly. However, there was no relationship between LRC and the typical right ear advantage. Thus, there is a sex- and task-dependent relationship between LRC and overall DL accuracy, but not between LRC and ear asymmetry. It is concluded that (a) atypical ear asymmetries, as in certain clinical populations, cannot be explained by associated deficits in left-right discrimination, and (b) LRC can negatively affect task performance, even when participants do not have to make explicit "left" versus "right" decisions.     

The Effectiveness of Functional Family Therapy for Adolescent Behavioral and Substance Misuse Problems: A Meta‐Analysis

A systematic review of published and unpublished English language articles identified 14 studies containing 18 comparisons between functional family therapy (FFT) and another condition in the treatment of adolescent disruptive behavior and substance use disorders. In 11 of these comparisons, assignment to conditions was random, while nonrandom assignment occurred in seven studies. For both random and nonrandom comparisons, separate meta‐analyses were conducted for subgroups of studies depending on the type of comparison group used. Data from studies of untreated control groups (CTL), treatment as usual (TAU), and well‐defined alternative treatments (ALTs) were analyzed separately. Effect sizes from these six meta‐analyses were as follows: random assignment FFT versus CTL (k = 3, d = 0.48, p < .01); random assignment FFT versus TAU (k = 3, d = .20, ns); random assignment FFT versus ALT (k = 5, d = .35, p < .05); nonrandom assignment FFT versus CTL (k = 2, d = .90, ns); nonrandom assignment FFT versus TAU (k = 2, d = .08, ns); and nonrandom assignment FFT versus ALT (k = 3, d = .75, p < .001). These results provide support for the effectiveness of FFT compared with untreated controls and well‐defined ALTs, such as cognitive behavior therapy, other models of family therapy, and individual and group therapy for adolescents.     

Matching the message source to attitude functions: Implications for biased processing

A study was conducted to examine the hypothesis that matching (vs. mismatching) the source of a persuasive message to the functional basis of recipients’ attitudes may lead to positively biased processing. Under conditions conducive to effortful processing, high and low self-monitors were presented with a persuasive message ascribed to a source that either matched or mismatched the functional basis of their attitudes (i.e., an expert source for low self-monitors and an attractive source for high self-monitors). The message content was either unambiguous strong, unambiguous weak, or ambiguous. As predicted, given an ambiguous message biased processing led to more agreement when the source matched (vs. mismatched) attitude functions. In contrast, an unambiguous strong message led to more agreement than an unambiguous weak message regardless of source matching (unbiased processing). Results are discussed with respect to the role of the activation and use of heuristics in biased processing.