The shared and unique genetic relationship between mental well-being,depression and anxiety symptoms and cognitive function in healthy twins

Alterations to cognitive function are often reported with depression and anxiety symptoms, yet few studies have examined the same associations with mental well-being. This study examined the association between mental well-being, depression and anxiety symptoms and cognitive function in 1502 healthy adult monozygotic (MZ) and dizygotic (DZ) twins, and the shared/unique contribution of genetic (G) and environmental (E) variance. Using linear mixed models, mental well-being was positively associated (p?β?=?0.127), inhibition (β?=?0.096), cognitive flexibility (β?=?0.149), motor coordination (β?=?0.114) and working memory (β?=?0.156), whereas depression and anxiety symptoms were associated (p?β?=??0.134), inhibition (β?=??0.139), cognitive flexibility (β?=??0.116) and executive function (β?=??0.139). Bivariate twin modelling showed well-being shared a small environmental correlation with motor coordination and a small genetic correlation with working memory. Trivariate twin modelling showed well-being shared a small genetic correlation with inhibition, whereas depression and anxiety symptoms shared a small environmental correlation with inhibition. The remaining variance was mostly driven by unique G and/or E variance. Overall, well-being and depression and anxiety symptoms show both independent and shared relationships with cognitive functions but this is largely attributable to unique G or E variance and small shared G/E variance between pairs of variables.     

Executive function and intelligence in the resolution of temporary syntactic ambiguity: an individual differences investigation

In the current study, we examined the role of intelligence and executive functions in the resolution of temporary syntactic ambiguity using an individual differences approach. Data were collected from 174 adolescents and adults who completed a battery of cognitive tests as well as a sentence comprehension task. The critical items for the comprehension task consisted of object/subject garden paths (e.g., While Anna dressed the baby that was small and cute played in the crib), and participants answered a comprehension question (e.g., Did Anna dress the baby?) following each one. Previous studies have shown that garden-path misinterpretations tend to persist into final interpretations. Results showed that both intelligence and processing speed interacted with ambiguity. Individuals with higher intelligence and faster processing were more likely to answer the comprehension questions correctly and, specifically, following ambiguous as opposed to unambiguous sentences. Inhibition produced a marginal effect, but the variance in inhibition was largely shared with intelligence. Conclusions focus on the role of individual differences in cognitive ability and their impact on syntactic ambiguity resolution.     

幼儿自我调节能力的发展及与气质的关系

本研究主要讨论幼儿自我调节能力的发展及与气质的关系。研究从执行功能的角度入手,采用实验法和问卷法对90名3～5岁的幼儿进行研究,通过创设难度递进的冲突情境来考察儿童在两种不一致规则中的转换能力。结果表明,幼儿自我调节能力的发展随年龄增长而提高,并存在显著的年龄差异;幼儿气质与自我调节能力的发展有着密切的关系,特别是专注性和社会抑制性维度对不同水平的幼儿自我调节能力的方差检验都达到了显著,二者与年龄一起,能够对幼儿自我调节能力进行一定程度的预测。     

The contribution of “cool” and “hot” components of decision-making in adolescence: Implications for developmental psychopathology

Impairments in either “cool” or “hot” processes may represent two pathways to deficient decision-making. Whereas cool processes are associated with cognitive and rational decisions, hot processes are associated with emotional, affective, and visceral processes. In this study, 168 boys were administered a card-playing task at ages 13 and 14 years to assess response perseveration. This task was designed to initially reward playing and gradually associate playing with punishment. Measures of subjective ordering (cool processes) and neuroticism (hot processes) at age 13 years were used to examine how these individual characteristics relate to perseveration over time. A decrease in perseveration from age 13 to 14 was associated with cool processes whereas hot processes were associated with response perseveration only over time. A complementary but simultaneous assessment of cool and hot processes, such as neuropsychological and personality tests, could facilitate treatment planning of children with behavioral problems.     

Estimation of premorbid cognitive function based on word knowledge: the Swedish Lexical Decision Test (SLDT)

In clinical neuropsychology, the present status of a patient is evaluated in relation to the assumed premorbid status. However, in Sweden, existing methods to assess premorbid status are far from optimal. In the present study, the design and evaluation of a Swedish Lexical Decision Test (SLDT) for premorbid global cognitive function (i.e., premorbid intelligence) is described. The design was based on the empirical finding that, in general adult population, word knowledge is strongly associated with measures of global cognitive functioning. Linear stepwise regression analysis demonstrated that SLDT findings accounted for 48% of the variance of global cognitive function as assessed by the Full Scale Intelligence Quotient (FSIQ) from the Wechsler Adult Intelligence Scale Revised (WAIS-R). Demographic variables alone accounted for 31% and a combination of SLDT results and demographics accounted for 60%. Psychometric properties are presented using data from 109 healthy individuals stratified according to age, gender, and level of education. In addition, a case of Alzheimer's disease is presented to illustrate the relationship between SLDT performance and cognitive function. Finally, the theoretical foundation for the relationship between word knowledge and global cognitive function is discussed.     

Some technical implications of Klein's concept of 'premature ego development'

In this paper, the author revisits the problem of 'premature ego development' first introduced by Melanie Klein in 1930. She also highlights several developments in post-Kleinian thinking since the publication of that paper, which can be seen as offshoots of or complements to Klein's work. The author proposes a link between this category of precocious development and the absence of the experience of what Bion termed the 'containing object.' She puts forward several technical considerations relevant to analytic work with patients who suffer as a result of early developmental failures and presents various clinical vignettes in order to demonstrate the ways in which these considerations take shape in the analytic setting.     

The effects of differential training procedures on linked perceptual class formation

When the stimuli in one perceptual class (A') become related to the stimuli in another perceptual class (B'), the two are functioning as a single linked perceptual class. A common linked perceptual class would be the sounds of a person's voice (class A') and the pictures of that person (class B'). Such classes are ubiquitous in real world settings. We describe the effects of a variety of training procedures on the formation of these classes. The results could account for the development of naturally occurring linked perceptual classes. Two perceptual classes (A' and B') were formed in Experiment 1. The endpoints of the A' class were called anchor (Aa) and boundary (Ab) stimuli. Likewise, the anchor and boundary stimuli in the B' class were represented as Ba and Bb. In Experiment 2, the A' and B' classes were linked by the establishment of one of four cross-class conditional discriminations: Aa-->Ba, Aa-->Bb, Ab-->Ba, or Ab-->Bb. Results were greatest after Aa-->Bb training, intermediate after Aa-->Ba and Ab-->Ba training, and lowest after Ab-->Bb training. Class formation was influenced by the interaction of the anchor/boundary values and the sample/comparison functions of the stimuli used in training. Experiment 3 determined whether class formation was influenced by different sets of two cross-class conditional discriminations: Aa-->Ba and Ab-->Bb, or Aa-->Bb and Ab-->Ba. Both conditions produced equivalent results. Similarities were attributable to the use of anchor stimuli as samples and boundary stimuli as comparisons in each training condition. Finally, the results afterjoint Aa-->Ba and Ab-->Bb training were much greater than those produced by summing the results of Aa-->Ba training alone and Ab-->Bb training alone. This same synergy was not observed after joint Aa-->Bb and Ab-->Ba training or either alone.     

Contextual control by function and form of transfer of functions

This study investigated conditions leading to contextual control by stimulus topography over transfer of functions. Three 4-member stimulus equivalence classes, each consisting of four (A, B, C, D) topographically distinct visual stimuli, were established for 5 college students. Across classes, designated A stimuli were open-ended linear figures, B stimuli were circular, C stimuli three-sided, and D stimuli four-sided. Three different computer tasks then were trained with the B stimuli. Differential reinforcement and punishment procedures were then used to establish control over function transfer by the topography of the class members. For Task 1, function transfer, responding to C and D stimuli as subjects had to B stimuli, was reinforced. For Task 2, function transfer was reinforced for C stimuli but punished for D stimuli. For Task 3, function transfer was punished for both C and D stimuli. New equivalence classes were then established and tests for generalized contextual control were presented. All 5 subjects showed generalized contextual control of transfer of functions by stimulus topography. Implications of contextual control over function transfer in natural settings are discussed.     

Numerosity discrimination in preschool children

We used a numerical bisection procedure to examine preschool children's sensitivity to the numerical attributes of stimuli. In Experiment 1 children performed two tasks. In the Cups Task they earned coins for choosing a green cup after two drumbeats and a blue cup after eight drumbeats. In the Gloves Task they earned coins for raising a red glove on their left hand after two drumbeats and a yellow glove on their right hand after eight drumbeats. Then in each task a psychometric function was obtained by presenting intermediate numerosities and recording the percentage of trials in which children chose the "many" option. In Experiment 2 children's performance in a '2 vs. 8' discrimination was compared with their performance in a "4 vs. 16" discrimination. Results showed that the individual psychometric functions were of two types, one in which the percentage of "many" choices increased gradually with stimulus numerosity and another in which it increased abruptly, in a step-like manner. Although the average point of subjective equality was close to the geometric mean of the anchor numerosities and the average functions for "2 vs. 8" and "4 vs. 16" superimposed when plotted on a common scale (the scalar property), the individual data were highly variable both across tasks (Cups and Gloves) and numerosity ranges ('2 vs. 8' and '4 vs. 16'). It is suggested that between- and within-subjects variability in the psychometric function is related to children's verbalizations about the sample stimulus.     

The fear of love: the denial of self in relationship

This paper explores the fear of love and relationship which develops when a child has experienced parents who cannot tolerate emotional separation and so attempt to retain perfect contingency with their infant, long after the infant needs to begin to separate and individuate. The child is a 'self-object' for the parents, who depend on the responses of others, including their own child, to maintain a sense of their own identity. The impact of this demand for 'reverse parenting' on the child's development is explored and clinical work with an adult patient whose history reflects this process is described.