Fetal Testosterone,Socio‐Emotional Engagement and Language Development

The present study investigated the relations among fetal testosterone, child socio‐emotional engagement and language development in a sample of 467 children (235 boys) from the Western Australian Pregnancy Cohort (Raine) Study. Bioavailable testosterone concentration measured in umbilical cord blood taken at birth was found to be significantly negatively correlated with socio‐emotional engagement and vocabulary development for boys but not for girls. Socio‐emotional engagement mediated the effect of boys' fetal testosterone levels on their vocabulary development. However, the size of the effects was small, and fetal testosterone and socio‐emotional engagement were no longer significant predictors of boys' vocabulary scores after accounting for the effects of other predictors including maternal age and education, parity, and parent–child book reading. It is concluded that further research into these associations is warranted in both typical and atypical development and that this research would profit from including a broader focus on the role that proximal processes such as socio‐emotional engagement, joint attention and imitation have in mediating the developmental effects of prenatal factors such as fetal testosterone exposure. Copyright © 2012 John Wiley & Sons, Ltd.     

Digit Ratio 2D:4D,facial masculinization and aggressiveness in Spanish adolescents / Índice 2D:4D,masculinización facial y agresividad en adolescentes españoles

Abstract

This study aims to test whether two morphometric characteristics, the second to fourth finger length ratio (2D:4D index) and the facial width-to-height ratio (FWH index), which reflects the degree of facial masculinization, are related to aggression in adolescents of both sexes. Previous studies have proposed that the 2D:4D index (a trait related to prenatal testosterone) and the FWH (related to testosterone during puberty) are related to aggressiveness in adult males (although there is evidence to the contrary). In the present study we investigate the relationship of both traits with different measures of aggression in a mixed population of 296 adolescents (14–19 years old). We did not find relationships between 2D:4D and FWH with aggressiveness. Furthermore, our results suggest that the FWH index must be used only after controlling for body mass index.     

Neuroprotective Effects of Testosterone on Regenerating Spinal Cord Motoneurons in Rats

Degeneration in the CNS and peripheral nervous system consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury. Testosterone is a gonadal sex steroid hormone that plays an important role in CNS development. One of the lesser-known testosterone actions is neuroprotection. In the present study, the authors investigated the neuroprotectective effect of intracerebral ventricular injection of testosterone on the number of spinal motoneurons after sciatic nerve crush. In all, 32 male Wistar rats were divided to 4 groups (control, compression, compression + castration, compression + testosterone injections; n = 8). Four weeks after compression the lumber segments of spinal cord were sampled, processed, sectioned serially, and stained with toluidine blue (pH = 4.65) by using steriological quantitative technique (physical dissector), the number of alpha motoneurons in the right ventral horns of spinal cord were counted and compared between groups. Statistical analyses showed that testosterone injections (1μl icv, 4 times, 1 week interval between injections) significantly (p < .05) reduced neuronal damage. These results indicated that testosterone has an obvious neuroprotective effect on lumbar spinal motoneurons.     

Foetal programming and cortisol secretion in early childhood: A meta-analysis of different programming variables

It is widely recognized that different events may take place in the intrauterine environment that may influence later developmental outcome. Scholars have long postulated that maternal prenatal stress, alcohol or drug use, and cigarette smoking may impact foetal formation of the hypothalamus–pituitary–adrenal (HPA) axis, which may later influence different aspects of early childhood socioemotional and cognitive development. However, results linking each of these factors with child cortisol secretion have been mixed. The current meta-analysis examined the relation between each of these programming variables and child cortisol secretion in studies conducted up to December 31st, 2012. Studies were included if they were conducted prior to child age 60 months, and if they reported an index of effect size linking either maternal prenatal stress, alcohol or drug use, or cigarette smoking with an index of child cortisol secretion. In total, 19 studies (N = 2260) revealed an average effect size of d = .36 (p < .001). Moderator analyses revealed that greater effect sizes could be traced to maternal alcohol use, to the use of retrospective research methodology, where mothers are questioned after childbirth regarding programming variables, and to the use of baseline measures of cortisol secretion, as opposed to recovery measures. Discussion focuses on processes that link the environment to foetal development and how both are linked to later adaptation.     

Lack of correlation between digit ratio (2D:4D) and Baron-Cohen’s “Reading the Mind in the Eyes” test, empathy, systemising, and autism-spectrum quotients in a general population sample

The second-to-fourth digit ratio (2D:4D) is sexually differentiated and is a likely biomarker for the organisational (permanent) effects of prenatal testosterone on the human brain. Recent research has highlighted a possible role of prenatal testosterone levels in both the etiology of autism-spectrum disorders and in sex and individual differences in cognitive styles of the normal mind (Baron-Cohen’s Extreme Male Brain Theory of Autism and Empathising/Systemising Theory). Importantly, autistic children present lower (hypermasculinised) 2D:4D than healthy controls. Based on these accounts, we investigated the relation of 2D:4D with Baron-Cohen’s measures of empathising (“Reading the Mind in the Eyes” test, RMET; Empathy Quotient, EQ), systemising (Systemising Quotient, SQ), and autistic-like traits (Autism-Spectrum Quotient, AQ) in the general population (N = 423 Austrian adults). Whereas sex differences into the expected direction and of expected size were obtained for all variables and internal scale consistencies tallied to retrievable reference values, 2D:4D was unrelated to RMET, EQ, SQ, and AQ scores. Candidate explanations for this lack of correlation might be possible developmental timing differences in the expression of 2D:4D and empathising/systemising, qualitative (as opposed to quantitative) functional differences between the normal and the autistic mind, or the suboptimal psychometric properties of the measures.     

Hormonal changes after competition predict sex‐differentiated decision‐making

Recent neuroendocrinology research has pointed out that testosterone (T) and cortisol (C) changes after social interactions can predict risk‐taking behavior in decision‐making, depending on the sex of participants. However, previous research has focused on the effects of the changes in only one hormone, rather than the interaction between them, even though C can suppress T activity. Our aim was to test, in men and women, the role of T changes moderated by C changes after competition in decision‐making. Thus, 48 males and 46 females completed the Iowa Gambling Task (IGT) after a laboratory competition or a noncompetitive task (control task). Saliva samples were collected before and after the competition/control task. IGT was employed to measure risk‐taking decision‐making, considering the degree of uncertainty. Our results showed sex‐differentiated effects of T and C changes on risk‐taking behavior. On the one hand, men from both task groups (Competition/Control) who had higher C and T changes after competition showed more risk‐taking decision‐making (higher IG Risk). On the other hand, women from the competitive task who had high C and T showed conservative decision‐making. Therefore, these results show sex‐differentiated decision‐making profiles, which would help to understand how men and women behave after experiencing a competitive social context.     

Gonadal hormones and intrasexual aggressive behavior in female bank voles (Clethrionomys glareolus)

The effects of gonadal hormones on aggressive behavior in the female bank vole was investigated in 10 min home cage tests. Ovariectomized (ovx) or intact females injected with oil, with progesterone (P), with a mixture of progesterone and estrogen (P+E), or with testosterone (T) alone were confronted in a resident-intruder test with unfamiliar, nonoperated females as intruders. Intact females showed aggressive behavior more frequently than ovx females. Ovx females injected with P, with P+E, or with T made significantly more attacks, and these attacks lasted longer than those observed for oil-treated voles. The results indicate that P, the typical female hormone, is responsible for aggressive behavior in female bank voles; however, only T increased the duration of interfemale aggression. Aggr. Behav. 24:63–70, 1998. © 1998 Wiley-Liss, Inc.     

Agonistic behavior,plasma testosterone,and hypothalamic estradiol binding in male rabbits

The purpose of this study was to establish a relation between agonistic behavior, gonadal hormones, and their receptorial capacity at the central level. Male rabbits were observed in seminatural conditions and three components of their agonistic behavior were recorded: follow, attack, and chase. The three behaviors were mutually correlated and clearly differed among the four members of each group. Within the social group, one rabbit was agonistically more active than the others and his supremacy was associated with an increased level of peripheral testosterone and higher estradiol binding in the hypothalamus. On the whole, the values of the hypothalamic estradiol binding were positively correlated with the behaviors. The results show that, in the male rabbit, agonistic activity is associated with changes in testosterone concentration and in the binding at the central level of its aromatized metabolite estradiol. Aggr. Behav. 23:33–40, 1997. © 1997 Wiley-Liss, Inc.     

Aggression and testosterone: Testing a bio-social model

Based upon reports of a positive correlation between circulating testosterone levels and aggression, we draw upon evolutionary psychology to place the action of testosterone in a broader perspective. We propose that testosterone affects competitive status-seeking and that under certain circumstances (including youth) this is expressed as aggression. Involvement in aggression in turn is associated with adherence to an instrumental social representation of aggression which justifies aggression as a means of imposing control over others and increasing self-esteem. Measures of salivary testosterone, masculinity, preferred social representation of aggression, and multiple aggression scales were collected from an undergraduate sample of 119 men. An Aggression factor was derived from principle components analysis of the aggression measures. The strongest correlates of Aggression were holding an instrumental social representation of aggression and youth. Testosterone showed no significant relationship to the single or aggregate measures of aggression or to any of the other psychometric measures. We suggest ways in which previous work may have over-estimated the strength of the association between circulating testosterone and aggression and discuss the possible relationships between age, social representation, and aggression. Aggr. Behav. 23:239–238, 1997. © 1997 Wiley-Liss, Inc.