语篇主题表征在大脑两半球的存贮

使用半视野速示技术和启动—再认探测方法,采用包含两个句子的短语篇作为前行信息、通过主题启动、歧义词启动探测语段阅读时主题表征在大脑两半球的存贮情况,结果发现,无论是主题启动还是歧义词启动,左视野／右半脑和右视野／左半脑对语境相关的目标词反应时间都比不一致目标词更长,说明语段阅读后两半脑对主题表征都有存贮。     

脑梗死不同病因亚型同血浆同型半胱氨酸浓度的关系研究

为探讨脑梗死患者血浆同型半胱氨酸（HCY）水平同病因分型及疾病严重程度的关系,选择首发脑梗死急性期患者73例,对照组30例,进行TOAST病因分型、NIHSS神经功能缺损评分、血浆HCY检测。结果显示,病例组血浆HCY升高率、水平比对照组显著增高;大动脉粥样硬化亚型病例组血浆HCY水平比对照组明显增高;病例组血浆HCY水平同NIHSS评分呈正相关,提示高HCY血症是脑梗死发病及大动脉粥样硬化亚型脑梗死发病的高危因素,血浆HCY水平同神经功能缺损程度正相关。     

Understanding Cognition Through Large-Scale Cortical Networks

An emerging body of evidence from a number of fields is beginning to reveal general neural principles underlying cognition. The characteristic adaptability of cognitive function is seen to derive from large-scale networks in the cerebral cortex that are able to repeatedly change the state of coordination among their constituent areas on a subsecond time scale. Experimental and theoretical studies suggest that large-scale network dynamics operate in a metastable regime in which the interdependence of cortical areas is balanced between integrating and segregating activities. Cortical areas, through their coordination dynamics, are thought to rapidly resolve a large number of mutually imposed constraints, leading to consistent local states and a globally coherent state of cognition.     

Basic visual perceptual processes in children with typical development and cerebral palsy: The processing of surface,length, orientation,and position

The present study aims to assess how the processing of basic visual perceptual (VP) components (length, surface, orientation, and position) develops in typically developing (TD) children (n = 215, 4–14 years old) and adults (n = 20, 20–25 years old), and in children with cerebral palsy (CP) (n = 86, 5–14 years old) using the first four subtests of the Battery for the Evaluation of Visual Perceptual and Spatial processing in children. Experiment 1 showed that these four basic VP processes follow distinct developmental trajectories in typical development. Experiment 2 revealed that children with CP present global and persistent deficits for the processing of basic VP components when compared with TD children matched on chronological age and nonverbal reasoning abilities.     

关于阵发性心房纤颤是否需要抗凝治疗的思考

阵发性心房纤颤与持续性心房纤颤同样面临着缺血性脑卒中风险,而关于阵发性房颤是否需要华法林抗凝治疗是目前争论热点问题。阵发性房颤是否抗凝治疗使患者面临着严重出血或血栓栓塞风险。循证医学论证了阵发性房颤抗凝治疗必要性及风险性,并且由于阵发性房颤患者有着不同的脑卒中及出血风险,个体差异的绝对性和多样性客观上要求对患者进行风险／效益比评估,在循证医学基础上进行个体化治疗。     

降纤酶治疗急性脑梗死的临床疗效评价

采用随机同期对照的临床研究方法,对发病在24h内的90例急性脑梗死患者,分别进行降纤酶与常规治疗方法的治疗,观察其疗效,应用Logistic回归分析方法进行评价。结果显示,降纤酶可降低血浆纤维蛋白原的水平,有效地促进神经功能恢复,改善急性脑梗死患者的临床症状,有着与常规治疗方法相同的临床疗效。     

轴突变性研究进展及思考

轴突变性是中枢神经系统疾病的基本病理过程,但是由于把其作为轴突失去胞体营养后的被动死亡,长期未受到重视。最近的研究发现轴突变性是神经元对外界刺激的可逆可控的主动过程,在这个研究过程中,我们体会到轴突变性所蕴涵的深刻哲学内涵,如其在细胞周期调控和凋亡的作用。这种研究使我们认识到应该用辩证的思维方法去认识分析客观事物。     

Education does not protect against age-related decline of switching focal attention in working memory

In this experimental study, effects of age and education on switching focal attention in working memory were investigated among 44 young (20-30 years) and 40 middle-aged individuals (50-60 years). To this end, a numeric n-back task comprising two lag conditions (1- and 2-back) was administered within groups. The results revealed a comparable increase of reaction time as a function of lag across age groups, but a disproportionate decrease of accuracy in the middle-aged relative to the young group. The latter effect did not interact with education, which challenges the cognitive reserve hypothesis. Moreover, the high-educated middle-aged participants showed a greater increase of reaction time as a function of lag than their low-educated counterparts. Apparently, they were not able to sustain their relatively high response speed across conditions. These results suggest that education does not protect against age-related decline of switching focal attention in working memory.     

The Institute for Music Physiology and Musicians’ Medicine

The Institute of Music Physiology and Musicians' Medicine of the University of Music and Drama in Hannover, Germany, is a unique Institution in Europe whose scope includes teaching the basics of music physiology and musicians' medicine and research into the physiological and neurobiological principles of professional music performance and music perception. Furthermore, the institute conducts research into the causes of occupational injuries in musicians and provides means for prevention, diagnosis and treatment of such injuries.