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691.
AbstractChanging automatized movement patterns often leads to initial performance decrements caused by proactive interference. In this study, we scrutinized whether proactive interference could be reduced by inhibiting the to-be-changed movement pattern by means of a physical movement constraint and verbal inhibition instructions, and whether any of the two interventions may be superior. Skilled typists typed short texts as fast and accurately as possible on a regular QWERTZ keyboard. After baseline measures, a new rule prohibiting the use of the left index finger was introduced. Subsequently, participants took part in either a verbal instruction or an additional motor restriction intervention phase. Results revealed that the original rule change was successful in inducing proactive interference in skilled typists. Most importantly, the two interventions similarly reduced proactive interference both immediately following the rule change and after ten practice sessions. We conclude that reducing proactive interference by means of physical motor restrictions and verbal instructions may be equally effective. 相似文献
692.
There is evidence which demonstrates that a subset of males with a premutation CGG repeat expansion (between 55 and 200 repeats) of the fragile X mental retardation 1 gene exhibit subtle deficits of executive function that progressively deteriorate with increasing age and CGG repeat length. However, it remains unclear whether similar deficits, which may indicate the onset of more severe degeneration, are evident in female PM-carriers. In the present study we explore whether female PM-carriers exhibit deficits of executive function which parallel those of male PM-carriers. Fourteen female fragile X premutation carriers without fragile X-associated tremor/ataxia syndrome and fourteen age, sex, and IQ matched controls underwent ocular motor and neuropsychological tests of select executive processes, specifically of response inhibition and working memory. Group comparisons revealed poorer inhibitory control for female premutation carriers on ocular motor tasks, in addition to demonstrating some difficulties in behaviour self-regulation, when compared to controls. A negative correlation between CGG repeat length and antisaccade error rates for premutation carriers was also found. Our preliminary findings indicate that impaired inhibitory control may represent a phenotype characteristic which may be a sensitive risk biomarker within this female fragile X premutation population. 相似文献