Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks

Ghrelin (Grh) is an endogenous ligand for the growth hormone secretagogue receptor. Although Ghr stimulates feeding in rats, it inhibits feeding in neonatal chicks. However, little is known about other central behavioral effects of Ghr. Therefore, we investigated the Ghr effects, injected intracerebroventricularly, on anxiety and memory retention of neonatal chicks in an Open Field test and in a one-trial passive avoidance task, respectively. In the Open Field test, the administration of Ghr in a dose-dependent manner increased the latency to ambulate but decreased ambulation activity, indicating an anxiogenic effect. Furthermore, chicks trained on a passive avoidance task and injected with a dose of 30 pmol of Ghr immediately after training showed an impairment of memory retention. However, there were no significant effects on the number of pecks during the pretraining, training, retention and discrimination. In addition, different doses of Ghr produced an inhibition in food intake at different times after injection. Our results indicate that Ghr induces anxiogenesis in chicks. Moreover, we have shown for the first time that Ghr can decrease memory retention in a non-mammalian species, suggesting that Ghr may play an important role in the processes of memory retention in birds.     

Cultural Similarity, Foreign Policy Actions, and Regime Perception: An Experimental Study of International Cues and Democratic Peace

This study examines previous explanations of democratic peace in light of sociocultural factors and foreign policy actions that influence public perceptions of another country. Two experiments assessed the effects of relevant sociocultural and foreign policy action cues on perception of the regime type of a target nation and on public approval of the use of force. The findings suggest that sociocultural cues affect regime perception. Moreover, perceived similarity of a target nation and foreign policy actions are significant determinants of the public approval of the use of force in addition to perceptions of regime type.     

Is the conflict model of decision making applicable to the decision to be screened for cervical cancer? A field study

The present study examined aspects of the conflict model of decision making (Janis and Mann, 1977) in the context of attending for a screening test for cervical cancer. In addition, the ability of decision coping styles as measured by Mann's (1982) Decision Making Questionnaire II (DMQ II) to predict screening status was examined. Three hundred and two women answered a questionnaire operationalizing the constructs in the conflict model about their beliefs and knowledge of cervical cancer and the Pap smear test. Four screening categories were identified: never screened, not screened in the last two years (overdue), screened in last two years and initiated the test, and screened in last two years and recruited to have the test. Differences in the decision processes of these groups were examined. Women who were overdue for their Pap test showed greater decisional conflict and were more likely to adopt a defensive avoidance coping pattern than those who had been screened in the last two years. Regression analyses exploring predictors of decisional stress and defensive avoidance for each group, except the never screen, showed that the model's suggested pathways were evidenced among the Overdue Group. Results failed to find any association between coping styles as measured by the DMQ II and screening status. Implications of these findings are discussed.     

« La malléabilité du cadre thérapeutique comme support d’élaboration sur les terrains de l’aide internationale »

IntroductionIn the field of international aid, the projects set up, including psychological care systems, must respond to international and local requirements regarding their financing and sustainability. In these contexts, clinical questions intersect with those of the systems and culture. The traumatic dimension remains prevalent, and these contexts often must deal with multiple local and international requirements. These dimensions can influence the devices set up and their evolution.ObjectivesThrough feedback from an action-research conducted in Cambodia, we question the evolutions and adaptations of a therapeutic device with abused children.MethodFor one year, a device based on mediation was proposed for 10 children hosted within a local child protection NGO. We describe here its implementation and its evolution in the field.ResultsThe setting up of the system was a vector of different meetings. The adjustments were made in relation to the institutional context, the meetings with the local actors and the specificities of the clinic.ConclusionThe evolutions of the therapeutic device seem to signify the processes at play, both on the institutional and intersubjective scene. Regarding these field returns, the malleability of the therapeutic devices in these contexts seems to support the expression and the processual evolution, allowing a work of psychic elaboration.     

Understanding the impact of heterogeneous rider preferences on a shared autonomous vehicle system

In a ride pooling system, riders may have varied behaviors in seeking pooled or non-pooled rides. It is important to understand the effect of these rider behaviors on the system performance in order to formulate policies to guide ride pooling implementation. Existing literature modeling ride pooling systems using agent-based models only considers the extreme cases in which riders either all participate or not participate in pooling. However, the pooling behaviors could be more complex. This study segments the rides in the system into five types (non-pooling only, non-pooling preferred, indifferent, pooling preferred, and pooling only). We use an agent-based model to simulate these preferences in a system of pooled autonomous vehicles. We use mixture experiments to vary the proportion of riders within these five types and build models to study the interactions among the rider types in terms of the system’s service quality and environmental performance. The results show that higher service level is achieved when all riders in the system are open to pooling, with 30% of pooling only riders and 70% of pooling preferred or indifferent riders providing the maximum value. The results can help formulate incentives and policies to promote ride pooling participation to improve ride pooling system performance.     

Emergency Research without Consent under Polish Law

Although Directive 2001/20/EC of the European Parliament and of Council of 4 April 2001 on the approximation of the laws regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use does not contain an exception for emergency situations, and requires the informed consent of a legal representative in all cases where research is conducted on legally competent individuals who are unable to give informed consent, in Poland, emergency research can be conducted without consent. Polish regulations on emergency research can hardly be treated as a result of intentional legislative policy. Our provisions arise from multiple and sophisticated interpretations of different regulations that govern medical experiments on human subjects and clinical trials. These interpretations can be summarized as follows: (1) There are two categories of medical experiments: therapeutic and non-therapeutic experiments. Emergency research without consent may be conducted in the category of therapeutic experiment only (therapeutic experiment consists of the introduction by the physician of new or only partially proven diagnostic, therapeutic or preventive methods in order to achieve direct benefit to the health of the patients, and it can be carried out when hitherto applied methods were ineffective or their effectiveness was insufficient). (2). Emergency research may be conducted without consent if there is a situation of great urgency in which the research subject's life is in danger and there is no possibility of obtaining immediate consent from the research subject him or herself, or from his or her legal representative or guardianship court, and the research subject has not refused to give consent for the participation in an emergency therapeutic experiment. The legal representative or guardianship court shall be provided with all the relevant information concerning subject's participation in an experiment as soon as possible. All projects of emergency research with intent to be done without the research subject's consent must be approved by an independent bioethics committee. Because these five requirements seem to provide insufficient protection for a subject's autonomy and rights it is necessary to add to them two other conditions: (1) the emergency research could not be conducted using other research participants capable of giving informed consent; and (2) informed consent for continued participation in the emergency research shall be obtained from either the participant him or herself or the legally authorized representative as soon as possible (requirement of obtaining deferred consent). A consolidated single Act that will govern all aspects of medical experiments on human subjects, including emergency research, should be prepared and enacted as soon as possible.     

The Admissibility of Research in Emergency Medicine

The main goal in this paper is to present the legal rules connected with medical experiment on human beings in emergency medicine and to explain the scope, significance, and meaning of these rules, especially with regard to their interpretation. As the provisions about medical experiments truly make sense only if they can be observed by the whole "civilised" international community, they are presented in the context of international law with reference to Polish law. By considering the appropriate regulations of research contained in legal documents, it is possible to formulate a catalogue of doctors' duties and patients' rights. This general catalogue refers to all kinds of medical research involving human beings. In the field of emergency medicine, general provisions are sometimes involved, and they are sometimes limited. The main and most important conclusion is that a medical experiment in emergency medicine is admissible only if previously indicated conditions based on general rules of conducting research are fulfilled.     

A field investigation of red-light-running in Shanghai,China

Red-Light-Running (RLR) is the major cause of severe injury crashes at signalized intersections for both China and the US. As several studies have been conducted to identify the influencing factors of RLR behavior in the US, no similar studies exist in China. To fill this gap, this study was conducted to identify the key factors that affect RLR and compare the contributing factors between US and China. Data were collected through field observations and video recordings; four intersections in Shanghai were selected as the study sites. Both RLR drivers and comparison drivers, who had the opportunity to run the light but did not, were identified. Based on the collected data, preliminary analyses were firstly conducted to identify the features of the RLR and comparison groups. It was determined that: around 57% of RLR crossed the stop line during the 0–0.4 second time interval after red-light onset, and the numbers of red light violators decreased as the time increased; among the RLR vehicles, 38% turned left and 62% went straight; and at the onset of red, about 88% of RLR vehicles were in the middle of a vehicle platoon. Furthermore, in order to compare the RLR group and non-RLR group, two types of logistic regression models were developed. The ordinary logistic regression model was developed to identify the significant variables from the aspects of driver characteristics, driving conditions, and vehicle types. It was concluded that RLR drivers are more likely to be male, have local license plates, and are driving passenger vehicles but without passengers. Large traffic volume also increased the likelihood of RLR. However, the ordinary logistic regression model only considers influencing factors at the vehicle level: different intersection design and signal settings may also have impact on RLR behaviors. Therefore, in order to account for unobserved heterogeneity among different types of intersections, a random effects logistic regression model was adopted. Through the model comparisons, it has been identified that the model goodness-of-fit was substantially improved through considering the heterogeneity effects at intersections. Finally, benefits of this study and the analysis results were discussed.     

Why study cognition in the wild (and how to test it)?

An animal's behavior is affected by its cognitive abilities, which are, in turn, a consequence of the environment in which an animal has evolved and developed. Although behavioral ecologists have been studying animals in their natural environment for several decades, over much the same period animal cognition has been studied almost exclusively in the laboratory. Traditionally, the study of animal cognition has been based on well‐established paradigms used to investigate well‐defined cognitive processes. This allows identification of what animals can do, but may not, however, always reflect what animals actually do in the wild. As both ecologists and some psychologists increasingly try to explain behaviors observable only in wild animals, we review the different motivations and methodologies used to study cognition in the wild and identify some of the challenges that accompany the combination of a naturalistic approach together with typical psychological testing paradigms. We think that studying animal cognition in the wild is likely to be most productive when the questions addressed correspond to the species’ ecology and when laboratory cognitive tests are appropriately adapted for use in the field. Furthermore, recent methodological and technological advances will likely allow significant expansion of the species and questions that can be addressed in the wild.     

An Intriguing Third Way: Mapping Contextual Education for Curricular Integration

This article emerges from the experience of incorporating doctoral students into our Contextual Education (CXE) Program at Emmanuel College (Toronto). This change, I argue, helped us to distinguish more clearly among and thus distinctly orient the different kinds of relationships and theological practices that make up our program towards the often‐elusive goal of curricular integration. After outlining a definition of integration, I contextualize that definition in our particular practices at Emmanuel College using Kathryn Tanner's (1997) understanding of theology as a cultural practice as my guide. I then offer a brief overview of our CXE Programs to demonstrate how nurturing strategic partnerships within them has made certain forms of integration possible for our students. I close with some activities for practical application in other CXE contexts.