Role of context similarity in ABA, ABC, and AAB renewal paradigms: Implications for theories of renewal and for treating human phobias

Using barpress conditioned suppression, we studied the renewal of conditioned fear in rats, an animal model for the relapse of human fears and phobias. We demonstrated ABA renewal when the only differences between Contexts A and B included (1) their odor, (2) their location (i.e., side of room), and (3) unintended differences between copies of the same box at the two sites. Removing either the odor or location cues abolished the renewal effect. We then directly compared the effects of ABA and AAB procedures under two levels of context similarity. Although AAB renewal occurred, ABA renewal was stronger. Adding multiple context distinctions to the three listed above did not significantly enhance either form of renewal. Finally, we directly compared the strengths of AAB, ABC, and ABA renewal. AAB renewal, though again significant, was weaker than ABA and ABC renewal, which did not differ significantly. Fear renewal (relapse) can thus be reduced by extinguishing the fear in the acquisition context, regardless of the nature of the test context.     

Exploring evaluative conditioning using a working memory task

Johnsrude, Owen, Zhao, and White (1999) demonstrated that evaluative conditioning (EC) can occur even while participants conduct a working memory task. This is consistent with claims that EC can occur outside awareness, and hence is an automatic process. In their study, three abstract patterns were paired differentially with a candy reinforcer: 90, 50, or 10%. On reinforced trials a red ball was presented in one of three locations on a computer screen. Participants were instructed to keep a tally for each location. We argue that if EC is automatic, then it will not consume cognitive/attentional resources, and hence co-occurrence of red ball and reinforcer should be irrelevant. Results from four experiments indicate that learning is only evident when the red ball and reinforcer co-occur or when the complexity of the working memory task is reduced. Together, the results suggest that EC is governed by specific attentional constraints on working memory. This interpretation questions the automatic nature of EC.     

Stress impairs acquisition of delay eyeblink conditioning in men and women

In rodents stress impairs delay as well as trace eyelid conditioning in females, but enhances it in males. The present study tested the effects of acute psychosocial stress exposure on classical delay eyeblink conditioning in healthy men and women. In a between subject design, participants were exposed to psychosocial stress using the Trier Social Stress Test (TSST) or a control condition which was followed by a delay eyeblink classical conditioning procedure. Stress exposure led to a significant increase in salivary cortisol and impaired acquisition of conditioned eyeblink responses (CRs). This was evident by a later first CR and an overall lower CR rate of the stress group. The stress-induced acquisition impairment was observed in both women and men. Subjects failing to show a stress-induced cortisol increase (cortisol non-responder) were not impaired in acquisition. Our findings indicate that acute stress, possibly via activation of the hypothalamus–pituitary–adrenal (HPA) axis, reduces the ability to acquire a simple conditioned motor response in humans.     

Experimentally Detecting How Cultural Differences on Social Anxiety Measures Misrepresent Cultural Differences in Emotional Well-being

Previous research, statistically accounting for self-construal factors and thereby eliminating widely reported culture main effects in social anxiety scores between East Asians and European-Americans (Norasakkunkit and Kalick 2002 Culture, ethnicity, and emotional distress measures: The role of self-construal and self-enhancement. Journal of Cross-Cultural Psychology, 33(1), 56–70.) suggested that social anxiety measures penalize individuals for being low on independent self-construal; therefore, cultural differences in emotional distress according to social anxiety measures may possibly misrepresent cultural differences in emotional well-being. In the current experimental study, 127 Japanese and 126 American participants were either primed or not primed to access an independent mode of thought prior to filling out two commonly used measures of social anxiety and a measure of emotional well-being. Independent priming caused social anxiety scores to decrease. Yet, independent priming did not influence levels of self-reported emotional well-being. Furthermore, although the Japanese respondents were shown to be more distressed according to both of the standardized social anxiety measures, this finding was actually reversed with respect to self-reported emotional well-being. The evidence thus points to high scores on measurements of social anxiety being directly and causally linked to low levels of independence, while no link was found between independence and emotional well-being.

阻碍条件性恐惧记忆消退的原因分析

创伤后应激障碍是个体经历严重应激后形成的一种焦虑障碍,对其治疗的关键是消退由创伤应激导致的条件性恐惧记忆,但目前最有效的暴露疗法并不能真正有效地抑制患者恐惧记忆的表达.对条件性恐惧的动物模型研究发现情绪性增强效应、恐惧记忆二级条件化与再巩固、内侧前额叶皮层功能不足等均能够阻碍条件性恐惧记忆的消退.针对这几个方面可以探索治疗创伤后应激障碍的相应方法.     

The development of an attentional bias for angry faces following Pavlovian fear conditioning

Although it is well documented that fear responses develop following aversive Pavlovian conditioning, it is unclear whether fear learning also manifests in the form of attentional biases for fear-related stimuli. Boschen, Parker, and Neumann (Boschen, M. J., Parker, I., & Neumann, D. L. (2007). Changes in implicit associations do not occur simultaneously to Pavlovian conditioning of physiological anxiety responses. Journal of Anxiety Disorders, 21, 788-803.) showed that despite the acquisition of differential skin conductance conditioned responses to angry faces paired (CS+) and unpaired (CS−) with an aversive shock, development of implicit associations was not subsequently observed on the Implicit Association Test. In the present study, participants (N = 76) were assigned either to a Shock or NoShock group and completed a similar aversive Pavlovian conditioning procedure with angry face CS+ and CS− stimuli. Participants next completed a visual probe task in which the angry face CS+ and CS− stimuli were paired with angry face control stimuli and neutral faces. Results confirmed that differential fear conditioning was observed in the Shock group but not in the NoShock group, and that the Shock group subsequently showed a selective attentional bias for the angry face CS+ compared with the CS− and control stimuli during the visual probe task. The findings confirm the interplay between learning-based mechanisms and cognitive processes, such as attentional biases, in models of fear acquisition and have implications for treatment of the anxiety disorders.     

Reducing chronic anxiety by making the threatening event predictable: An experimental approach

Panic disorder is characterized by both specific, phased fear and generalized, chronic anxiety. Standard extinction procedures are efficient in reducing specific fear. However, methods based on human conditioning research - that are capable of reducing chronic anxiety have not yet been thoroughly investigated. This study evaluates a new way of reducing chronic anxiety by signaling aversive events (or by making them more predictable). Using an experimental approach with healthy participants, specific fear and chronic anxiety were operationalized in a within-subjects fear-potentiated startle paradigm by, respectively, conditioning to a cue by presenting predictable shocks and conditioning to a context induced by unpredictable shocks. The results clearly demonstrate that context conditioning is reduced when a discrete cue is added that predicts the onset of the aversive event. The data suggest that making unpredictable events, such as for example panic attacks, predictable, may reduce the generalized and sustained anxiety that often complicates exposure treatment.     

Fear and disgust processing during repeated exposure to threat-relevant stimuli in spider phobia

Although disgust plays a significant role in the etiology of spider phobia, there remains a paucity of research examining the role of disgust in the treatment of spider phobia. Spider fearful participants (N = 46) were randomly assigned to a disgust (view vomit images) or neutral activation (view inanimate objects) condition. They were then repeatedly exposed to a videotaped tarantula, during which time their fear, disgust, and physiological levels were assessed repeatedly. Growth curve analyses indicated that repeated exposure led to significant declines in fear and disgust with no statistically significant differences between the two conditions. However, there was marginal evidence for decreased physiological arousal during repeated exposure among spider fearful participants in the disgust activation condition compared to those in the neutral condition. Reduction in disgust during exposure in the disgust activation condition remained significant after controlling for change in fear, whereas change in fear was no longer significant after controlling for change in disgust. However, the opposite pattern of relations between change in fear and disgust was observed in the neutral activation condition. Higher fear and disgust activation during exposure was also associated with higher fear and disgust responding on a subsequent behavioral task and higher spider fear and disgust at 3-month follow-up. Baseline trait disgust propensity also predicted fear and disgust parameters during repeated exposure. The implications of these findings for the role of disgust in the treatment of spider phobia are discussed.     

Implicit learning of evaluative vs. non-evaluative covariations: The role of dimension accessibility

Implicit covariation learning, the development of simple associations without awareness, has been demonstrated repeatedly along the evaluative dimension [De Houwer, J., Thomas, S., & Baeyens, F. (2001). Associative learning of likes and dislikes: A review of 25 years of research on human evaluative conditioning. Psychological Bulletin, 127, 853-869], but associations involving other dimensions appear more difficult to learn implicitly. The present research highlights the unique properties of the evaluative dimension that may predispose it to implicit learning. We provide evidence in the first experiment that implicit covariation learning occurs along the evaluative dimension, but does not spontaneously occur along non-evaluative dimensions. In Experiment 2, implicit learning along non-evaluative dimensions occurred when participants were subliminally primed with the to-be-learned dimension. In the discussion, we integrate findings from implicit evaluative conditioning research with the broader implicit learning literature.     

Learning to like or dislike by association: No need for contingency awareness

One way to learn to like or dislike a neutral target stimulus is through associations with positive or negative context stimuli. The present research investigates whether people need to be aware of the association between a target and a context stimulus (i.e., contingency aware) in order for associative learning of likes and dislikes to occur. We predicted that awareness of the association between context and target is necessary when target novelty is low, but not when target novelty is high. We conducted two experiments in which we varied target novelty and measured contingency awareness using a picture-bound recognition task. This allowed us to separately investigate evaluative conditioning for “contingency awareness” and “contingency unawareness” context–target pairs. The results show, as predicted, that awareness of the association between context and target is needed for low-novelty targets but not needed for high-novelty targets.