谈谈中国临床试验研究中受试者权益保障问题

随着国家《药品临床试验管理规范》的颁布与实施,我国新药临床试验研究水平有相当的提高,但也存在着一些问题。其中包括保护受试者权益问题。国家GCP有关章节中明确指出要保护受试者权益。并有具体规定,但在执行中尚有出入,如试验方案未经伦理委员会批准,未向受试者告知试验内容。或告知的不够充分,甚至在未签署知情同意书时就开始试验等。为此,我国采取了相应的措施,如设立药品临床研究培训中心;定期对临床试验基地的研究者以及相关人员如与试验有关的医师,药师及申办者进行GCP培训,基地审核制度,以法律手段来保证受试者权益等。     

Helping to overcome intervention inertia in bystander’s dilemmas: Behavioral disinhibition can improve the greater good

Conventional wisdom holds that behavioral disinhibition has negative effects on what humans do. Behavioral disinhibition may indeed frequently have negative effects, but in the present paper we reveal some positive consequences as well: the disinhibition hypothesis proposed here states that people may feel inhibited to intervene in situations in which non-intervening bystanders are present and that, therefore, behavioral disinhibition may help to overcome the bystander effect. Findings presented here provide evidence supporting this prediction both inside and outside the psychology laboratory: in both real-life and controlled bystander situations, people were more likely and faster to provide help when (unrelated to the bystander situations) they had (vs. had not) been reminded about having acted with no inhibitions. These findings suggest that, in contrast with what various theories and worldviews dictate, behavioral disinhibition may have positive effects on helping behavior and hence can be conducive for the greater good.     

THINKING ABOUT THE GOOD: RECONFIGURING LIBERAL METAPHYSICS (OR NOT) FOR PEOPLE WITH COGNITIVE DISABILITIES

Abstract: Liberalism welcomes diversity in substantive ideas of the good but not in the process whereby these ideas are formed. Ideas of the good acquire weight on the presumption that each is a person's own, formed independently. But people differ in their capacities to conceptualize. Some, appropriately characterized as cerebral, are proficient in and profoundly involved with conceptualizing. Others, labeled cognitively disabled, range from individuals with mild limitations to those so unable to express themselves that we cannot be sure whether their behavior is mediated by concepts at all. Constricted cognitive capacities have been thought to prevent participation in the prescribed process for forming personalized ideas of the good. So liberal theory, when formulating principles and practices of justice, often disregards cognitively disabled peoples' perspectives. We put aside metaphysically driven notions about personhood and show how interpersonal processes of "prosthetic" thinking (different from surrogacy) can satisfy liberalism's standards, positioning cognitively disabled individuals as fully participating subjects of justice.     

LOVE IN THE "UNIDIVERSE": A SALESIAN PERSPECTIVE ON CHANCE

The notion of the universe evolving through an interplay of law and chance raises numerous theological questions. In particular, scientific evidence of chance confronts images of God and divine action within this emerging worldview. To interpret Christian faith within a scientific world, figures from church tradition are drawn into the conversation, and a particular spirituality is appropriated to highlight the relationship between science and religion. The personal, practical, accessible spirituality of Saint Francis de Sales is retrieved for the discussion. This Christian humanist recognized the love of God as paramount to a human-divine relationship. The themes of divine providence and the will of God illustrate a spirituality of the heart that provides relevant insights into the theological implications of chance. An overview of how the reality of chance has posed numerous questions is considered before drawing on the spirituality of de Sales. Various theological views on chance are presented. As Salesian thought enhances an understanding of divine action in a world of chance, contemporary theologies of chance provide a framework for understanding the teachings of the saint in a new way.     

基于传统人性论的德育思考

传统人性论蕴含着丰富的德育资源,为我们提供了多方厩的经验、教训和启示：教化成善,发挥德育潜移默化的作用;顺乎人性,坚持德育中和适度的原则;修身养性,注重道德主体自觉的培养;以人为本,落实德育科学发展的理念。     

社会公平感、机构信任度与公共合作意向

社会公平从古至今都是人类追求的崇高社会理想。对社会公平的感知即社会公平感直接决定着个体的机构信任,并影响其公共合作参与。本研究将社会公平感分为分配公平和程序公平,将机构信任度分为工具信任和动机信任,采用实验室情境设计的方法,引入最后通牒博弈和免责博弈范式,通过2个实验系统探讨"公正无私,一言而万民齐"的因果机制。研究发现分配公平与程序公平正作用于个体的公共合作态度与意向,在此基础上建立起公共合作的双路径模型:外部路径由分配公平产生工具信任和动机信任,进而触发公共合作;内部路径由程序公平产生动机信任和工具信任,进而触发公共合作;二者结合构成个体参与公共合作的双动力系统。双路径模型的适用性在组织情境和社会情境下均得到了支持。     

When the Common Good Takes the Grand(est) Stage The Cosmic Common Good: Religious Grounds for Ecological Ethics,Daniel P. Scheid,Oxford University Press, 2016 (ISBN 978‐0‐19‐935943‐1), xvi + 248 pp., hb £19.99

Rooting itself in Catholic social teaching rather than theology of creation, this book develops a novel approach to Catholic ecological ethics. It argues that the traditional conception of the social common good should be fully broadened to encompass all creation, including abiota. Furthermore, the book suggests a comparative‐theological approach to ecological ethics through careful conversations with Buddhist, Hindu, and American Lakota conceptions and practices. While its vision of the cosmic common good at times appears too inclusive and perhaps ‘too good to be true’, this book is a valuable contribution to Christian ecological ethics and includes a fresh comparative‐theological take on ecological questions.     

Good education,the good teacher,and a practical art of living a good life: a Catholic perspective

What is good education? We value education for reasons connected to the good provided by education in society. This good is connected to be the pedagogical aim of education. This article distinguishes five criteria for good education based on the concept of ‘Bildung’.

Next, these five criteria are used to develop the idea of the good teacher. The rationale behind the analysis is that the good teacher should be able to realise what we consider to be good education. There are different traditions of religiously affiliated schools in the world. This article gives insight into the idea of the good teacher in two documents of the Catholic Congregation of Education on the lay teacher. Finally, the article focuses on the formation of a practical art of living a good life. Again, the five characteristics of good education structure the analysis of this type of educational formation.     

Agency and Normative Self-Governance

We are agents: we can deliberate about what to do, and then act on the basis of that deliberation. We are also capable of normative self-governance: we can identify and respond to reasons as reasons. Many theorists believe that these two capacities are intimately connected. On the basis of this connection they conclude that practical reasoning must be carried out under the guise of a justification. This paper explores two strategies for avoiding that conclusion. The first, which just denies the connection between agency and normative self-governance, is rejected as too costly, since it leaves the normative significance of agency unexplained. The second, which suggests that we can respond to a consideration as a reason without representing it as a reason, seems more promising, but it requires a reductive account of reasons for action. The upshot is that metaethics and action theory are entwined in ways that few have recognized.     

童年亲子关系与“好资源”对未婚男性性开放态度的影响

本研究采用实验启动的方式探讨“好资源”和童年环境对未婚男性性开放态度的影响, 结果发现童年亲子关系(而不是童年经济状况)在资源线索启动和性开放态度之间存在显著调节作用。研究1采用想象启动来控制个体的资源获取状况, 结果发现：童年亲子关系差的个体在“好资源”想象时其性开放态度较“差资源”想象时明显提升。研究2采用图片情境的资源想象方式, 在研究1的基础上进一步把亲子关系细分成亲子沟通、亲子焦虑和亲子回避三个维度, 结果表明：童年亲子回避在男性资源状况启动和性开放态度之间存在显著调节作用, 童年亲子高回避的个体在“好资源”照片情境想象下其性开放态度显著提升, 而童年亲子低回避的个体在“好资源”照片情境想象下其性开放态度明显下降; 此外, 童年亲子回避在性开放态度上的主效应显著, 亲子回避程度高的个体其性开放态度也更高。两个研究共同揭示了“男人有钱就变坏”的情境和群体特殊性。