Somatic Markers and Response Reversal: Is There Orbitofrontal Cortex Dysfunction in Boys with Psychopathic Tendencies?

This study investigated the performance of boys with psychopathic tendencies and comparison boys, aged 9 to 17 years, on two tasks believed to be sensitive to amygdala and orbitofrontal cortex functioning. Fifty-one boys were divided into two groups according to the Psychopathy Screening Device (PSD, P. J. Frick & R. D. Hare, in press) and presented with two tasks. The tasks were the gambling task (A. Bechara, A. R. Damasio, H. Damasio, & S. W. Anderson, 1994) and the Intradimensional/Extradimensional (ID/ED) shift task (R. Dias, T. W. Robbins, & A. C. Roberts, 1996). The boys with psychopathic tendencies showed impaired performance on the gambling task. However, there were no group differences on the ID/ED task either for response reversal or extradimensional set shifting. The implications of these results for models of psychopathy are discussed.     

Relationships between executive function,working memory,and decision-making on the Iowa Gambling Task: Evidence from ventromedial patients,dorsolateral patients,and normal subjects

The results of previous studies are inconsistent in regard to the relationship between the Iowa Gambling Task (IGT), working-memory (WM), and executive tasks, and whether these cognitive processes could be considered as mechanisms underlying a decision-making deficit. Moreover, the relationship between the IGT and executive measures is examined based on a limited number of executive tasks, within different populations showing diffuse damage. In addition, there are fewer studies carried out within control participants, with those studies also being inconclusive. It is also suggested that the association of the IGT performance with executive tasks depends on whether the IGT was running under ambiguity or under risk. In this work, all of these issues are studied. Results showed that both patients with ventromedial (VMPFC, N = 10) and dorsolateral (DLPFC, N = 10) prefrontal cortex lesions are significantly impaired on almost all executive tasks, WM tasks, and the IGT. Furthermore, when the IGT is run under risk, there are significant correlations between executive measures and the IGT for the DLPFC patients and the control participants (N = 34) but not the VMPFC patients. No correlation was found between WM tasks and the IGT for both frontal subgroups and control participants. These findings suggested that the mechanisms underlying the IGT deficit differ according to the lesion locations.     

Numbsense of shape,texture, and objects after left parietal infarction: A case report

Numbsense is a phenomenon, wherein patients can correctly respond to somatosensory stimuli at a higher rate than expected by chance, but cannot perceive the same stimuli consciously. Previously, numbsense has been reported in tactile localization of stimuli on the patient’s own body. Here, we describe a patient with numbsense that involved touched objects. The patient could not recognize the majority of somatosensory stimuli after left parietal infarction, but could correctly select shape, texture, and object stimuli more frequently than expected by chance.     

Integrated memory for objects, places, and temporal order: evidence for episodic-like memory in mice

Human episodic memory refers to the recollection of an unique past experience in terms of what happened, and where and when it happened. Factoring out the issue of conscious recollection, episodic memory, even at the behavioral level, has been difficult to demonstrate in non-human mammals. Although, it was previously shown that rodents can associate what and when or what and where information given on unique trials, it proved to be difficult to demonstrate memory for what, where, and when simultaneously in mammals, without using extensive training procedures, which might induce semantic rather than episodic memory recall. Towards the goal of an animal model of human episodic memory we designed an three-trial object exploration task in which different versions of the novelty-preference paradigm were combined to subsume (a) object recognition memory, (b) the memory for locations in which objects were explored, and (c) the temporal order memory for object presented at distinct time points. We found that mice spent more time exploring two "old familiar" objects relative to two "recent familiar" objects, reflecting memory for what and when and concomitantly directed more exploration at a spatially displaced "old familiar" object relative to a stationary "old familiar" object, reflecting memory for what and where. These results suggest that during a single test trial the mice were able to (a) recognize previously explored objects, (b) remember the location in which particular objects were previously encountered, and (c) to discriminate the relative recency in which different objects were presented. According to the currently discussed behavioral criteria for episodic-like memory in animals, our results suggest that mice are capable to form such higher order memories.     

情绪大脑机制研究的进展

文章综述情绪大脑机制研究的最新进展。情绪的脑机制——大脑回路,包括前额皮层、杏仁核、海马、前部扣带回、腹侧纹状体等。前额皮层中的不对称性与趋近和退缩系统有关,左前额皮层与趋近系统和积极感情有关,右前额皮层与消极感情和退缩有关。杏仁核易被消极的感情刺激所激活,尤其是恐惧。海马在情绪的背景调节中起着重要作用。前额皮层和杏仁核激活不对称性的个体差异是情绪个体差异的生理基础。情绪的中枢回路有可塑性。     

抑郁倾向对合作的影响：双人同步近红外脑成像研究

抑郁人群不但表现出注意、记忆等个体认知层面的负性偏向,还伴随有明显的社会认知障碍。已有研究在抑郁对社会认知的影响方面还考察得不多。本研究采用囚徒困境范式考察抑郁倾向对社会合作的影响。结果显示,高抑郁倾向组比低抑郁倾向组的合作率更低,双侧背外侧前额叶的激活更弱,抑郁对右侧背外侧前额叶及眶额叶的脑间同步性有调节作用;低抑郁被试与低抑郁被试配对时右侧颞顶联合区脑间同步性强于高抑郁被试与高抑郁被试配对,或者高抑郁被试与低抑郁被试配对时的右侧颞顶联合区脑间同步性,该效应当且仅当双方的选择相同时显著。结果表明,抑郁群体在社会奖赏加工、冲突控制及心理理论脑区均存在功能性缺陷,这些结果为理解抑郁人群合作意愿下降提供了脑成像证据。     

自我控制资源与认知资源相互影响的机制:整合模型

尽管有学者认为自我控制资源和认知资源应该是两种独立的资源,但近期的研究却表明两种资源是互相影响的.以往研究从执行控制的角度解释两种资源为什么相互影响,但却没有指出两种资源如何影响执行控制,以及缺乏考虑神经机制和自我控制资源调节变量在其中的作用.为更系统地解释两种资源相互影响的机制,作者提出了一个整合模型,该模型指出:(1)两种资源相互影响的主要原因是两者都受到执行控制和前额叶皮层的影响;(2)个体进行自我控制或认知加工会消耗能量,产生心理疲劳,降低执行任务的动机,表现为前额叶皮层激活水平下降;(3)前额叶皮层激活不足进一步限制了执行控制在随后的自我控制和认知加工任务中的作用,因而影响后续自我控制或认知加工任务的表现;(4)自我控制资源调节变量通过提高个体对疲劳的耐受性、补充能量和提高动机等方法,使前额叶皮层和执行控制在完成前一阶段任务后仍然能够正常发挥作用,从而维持个体在后续自我控制或认知加工任务上的表现.未来的研究可考察自我控制资源与其他认知加工的关系;用动态的认知神经研究方法,建立前额叶皮层激活水平在前后两阶段任务之间的中介作用模型,以及研究自我控制资源调节变量的神经机制.     

Can Constructive Thinking Predict Decision Making?

We assume that executive function constitutes an integrated set of cognitive processes that mediate working memory, planning, inhibition, flexibility, and decision making. Despite the acknowledged theoretical connection between executive function processes and emotional intelligence, such relationships have rarely been investigated. The purpose of this study was to examine the potential relationship between constructive thinking, conceived as a component of emotional intelligence, and executive function, as indexed by various existing neuropsychological and experimental instruments. We used the Constructive Thinking Inventory as a measure of emotional intelligence. We found that some constructive thinking subscales were able to predict distinct executive function variables. Emotional Coping, Categorical Thinking, and Esoteric Thinking subscales explained performance on various measures of executive function. Thus, we conclude that intervention programs designed to train a specific component of emotional intelligence, namely constructive thinking, could also facilitate performance in executive function processes, and vice versa. Copyright © 2011 John Wiley & Sons, Ltd.