An experimental approach to detecting dementia in Down syndrome: a paradigm for Alzheimer's disease

Measures developed from animal models of aging may detect dementia of the Alzheimer's type in a population at-risk for Alzheimer's disease (AD). Although, by middle age, individuals with Down syndrome (DS) show an extraordinarily high prevalence of AD-type pathology, their severe idiopathic cognitive deficits tend to confound the clinical diagnosis of AD. The current study was designed to improve detection of AD in DS by using measures of learning and memory derived from animal models of aging. Adults with DS (N=34) were assessed and reassessed (n=19) approximately one year later using stimulus-response (S-R) test methods derived from experimental literature, as well as standardized informant-based tests. Results demonstrated high validity and reliability of select tests. The implication of early symptom detection in a population at-risk for AD-type dementia was discussed in terms of potential brain regions of interest.     

High impact running improves learning

Regular physical exercise improves cognitive functions and lowers the risk for age-related cognitive decline. Since little is known about the nature and the timing of the underlying mechanisms, we probed whether exercise also has immediate beneficial effects on cognition. Learning performance was assessed directly after high impact anaerobic sprints, low impact aerobic running, or a period of rest in 27 healthy subjects in a randomized cross-over design. Dependent variables comprised learning speed as well as immediate (1 week) and long-term (>8 months) overall success in acquiring a novel vocabulary. Peripheral levels of brain-derived neurotrophic factor (BDNF) and catecholamines (dopamine, epinephrine, norepinephrine) were assessed prior to and after the interventions as well as after learning. We found that vocabulary learning was 20 percent faster after intense physical exercise as compared to the other two conditions. This condition also elicited the strongest increases in BDNF and catecholamine levels. More sustained BDNF levels during learning after intense exercise were related to better short-term learning success, whereas absolute dopamine and epinephrine levels were related to better intermediate (dopamine) and long-term (epinephrine) retentions of the novel vocabulary. Thus, BDNF and two of the catecholamines seem to be mediators by which physical exercise improves learning.     

Promoting foot–leg movements in children with multiple disabilities through the use of support devices and technology for regulating contingent stimulation

The present study assessed the possibility of promoting pre-ambulatory foot–leg movements in children with multiple disabilities by motivating their action through contingent stimulation combined with a support device. Two children aged 10 and 8 years participated. Microswitch technology (i.e., pressure sensors under the shoes or optic sensors at the front–inner side of the shoes) served for detecting the foot–leg movements and providing contingent stimulation on their occurrence. Sensor activation produced 5 s of stimulation during intervention. Data showed that both children had significant increases in foot–leg movements during the intervention phases. Implications of the data in terms of skill acquisition and further intervention prospects are discussed.     

On the Conditions for Generative Collaboration: Learning Through Collaborative Research

Drawing on autobiographical recollections, I propose to see collaborative research as a learning experience. I assume a sociocultural psychological approach to the social understanding and interpretation of different scientific research practices. I examine the modalities of collaboration in my first experience of managing an important national research project on Italian families’ dinner table conversations, and in a larger collaborative research endeavor concerning the everyday life of middle-class Italian, Swedish and US families from a comparative view (the Sloan project). On the basis of these experiences, I highlight some of the difficulties met by two other projects presented in this special issue, the DUNES project (Tartas and Muller Mirza, this issue) and the Transition project (Markova and Plichtova, this issue). I conclude by suggesting a provisional criterion for generativity in collaborative research. I suggest that generativity occurs when the more expert and academically oldest ones become conscious that they are learning something new from the group and from some other, independently from age and experience.

Children’s career development: A research review from a learning perspective

Recent advances in career theory have resulted in widespread acceptance of the lifespan perspective on development. However, a review of research and practice conducted during 2001 revealed that little attention has been paid to the career development of children (Whiston & Brecheisen, 2002). In response to calls for a greater concentration on this important stage in the lifespan, the present article uses learning as a unifying theme to structure a research review of career development in children. This theme highlights the need to understand more holistically the influences on and the process of career development learning in children. The learning framework accommodates the dynamic and interactional nature of career development and suggests the need for dual focus research that examines the what and the how of children’s career development learning.     

Learning from your mistakes: does it matter if you’re out in left foot,I mean field?

Studies have shown that generating errors prior to studying information (pencil–?) can improve target retention relative to passive (i.e., errorless) study, provided that cues and targets are semantically related (pencil–ink) and not unrelated (pencil-frog). In two experiments, we manipulated semantic proximity of errors to targets during trial-and-error to examine whether it would modulate this error generation benefit. In Experiment 1, participants were shown a cue (band–?) and asked to generate a related word (e.g., drum). Critically, they were given a target that either matched the semantic meaning of their guess (guitar) or mismatched it (rubber). In Experiment 2, participants studied Spanish words where the English translation either matched their expectations (pariente–relative) or mismatched it (carpeta–folder). Both experiments show that errors benefit memory to the extent that they overlap semantically with targets. Results are discussed in terms of the retrieval benefits of activating related concepts during learning.