Ethanol state-dependent memory: involvement of dorsal hippocampal muscarinic and nicotinic receptors

In the present study, the effects of bilateral injections of cholinergic agents into the hippocampal CA1 regions (intra-CA1) on ethanol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intraperitoneal injection (i.p.) of ethanol (0.25, 0.5 and 1 g/kg) dose dependently induced impairment of memory retention. Pre-test administration of ethanol (0.5 and 1 g/kg, i.p.) induced state-dependent retrieval of the memory acquired under pre-training ethanol (1 g/kg, i.p.) influence. Pre-test intra-CA1 injection of physostigmine (2.5 and 5 μg/mouse, intra-CA1) or nicotine (0.3 and 0.5 μg/mouse, intra-CA1) improved pre-training ethanol (1 g/kg)-induced retrieval impairment. Moreover, pre-test administration of physostigmine (2.5 and 5 μg/mouse, intra-CA1) or nicotine (0.3 and 0.5 μg/mouse, intra-CA1) with an ineffective dose of ethanol (0.25 g/kg) significantly restored the retrieval and induced ethanol state-dependent memory. Pre-test intra-CA1 injection of the muscarinic receptor antagonist, atropine (4 and 8 μg/mouse, intra-CA1) or the nicotinic receptor antagonist, mecamylamine (2 and 4 μg/mouse, intra-CA1) 5 min before the administration of ethanol (1 g/kg, i.p.) dose dependently inhibited ethanol state-dependent memory. Pre-test intra-CA1 administration of physostigmine (0.5, 2.5 and 5 μg/mouse), atropine (2, 4 and 8 μg/mouse), nicotine (0.1, 0.3 and 0.5 μg/mouse) or mecamylamine (1, 2 and 4 μg/mouse) alone cannot affect memory retention. These findings implicate the involvement of a dorsal hippocampal cholinergic mechanism in ethanol state-dependent memory and also it can be concluded that there may be a cross-state dependency between ethanol and acetylcholine.     

The Logic of Critique

This paper attempts to define the concept of critique, explain its function␣and properties and distinguish it from the close concept of evaluation. It is argued that, beyond the argument, a critique is concerned with the position of the proponent relatively to the reality the argument is about. Moreover, a critique is itself an argument in which assumptions regarding the position of the proponent are justified for a given audience on the basis of the proponent’s argumentative background within a specific domain.     

客体运动方向的视觉工作记忆容量

记忆动态场景中多客体的特征和时空信息是人类重要的认知活动。目前有关视觉工作记忆的研究虽然广泛探讨了对视觉信息的存储容量及机制,然而所采用的刺激材料均呈现于静态场景中,且不包含运动信息。而有关多客体追踪的研究只关注动态场景中多客体信息的实时更新,而不涉及一段时间内对客体信息的保持。本研究结合视觉工作记忆领域的变化觉察范式和多客体追踪范式,以独立运动的客体为刺激材料,探讨多个客体的运动方向信息在工作记忆中的存储容量问题。结果表明,在工作记忆中能够存储大约3个客体的运动方向信息。     

The effects of task-irrelevant threatening stimuli on orienting- and executive attentional processes under cognitive load

Human visual attention is biased to rapidly detect threats in the environment so that our nervous system can initiate quick reactions. The processes underlying threat detection (and how they operate under cognitive load), however, are still poorly understood. Thus, we sought to test the impact of task-irrelevant threatening stimuli on the salience network and executive control of attention during low and high cognitive load. Participants were exposed to neutral or threatening pictures (with moderate and high arousal levels) as task-irrelevant distractors in near (parafoveal) and far (peripheral) positions while searching for numbers in ascending order in a matrix array. We measured reaction times and recorded eye-movements. Our results showed that task-irrelevant distractors primarily influenced behavioural measures during high cognitive load. The distracting effect of threatening images with moderate arousal level slowed reaction times for finding the first number. However, this slowing was offset by high arousal threatening stimuli, leading to overall shorter search times. Eye-tracking measures showed that participants fixated threatening pictures more later and for shorter durations compared to neutral images. Together, our results indicate a complex relationship between threats and attention that results not in a unitary bias but in a sequence of effects that unfold over time.     

Infants perceive human point-light displays as solid forms

While five-month-old infants show orientation-specific sensitivity to changes in the motion and occlusion patterns of human point-light displays, it is not known whether infants are capable of binding a human representation to these displays. Furthermore, it has been suggested that infants do not encode the same physical properties for humans and material objects. To explore these issues we tested whether infants would selectively apply the principle of solidity to upright human displays. In the first experiment infants aged six and nine months were repeatedly shown a human point-light display walking across a computer screen up to 10 times or until habituated. Next, they were repeatedly shown the walking display passing behind an in-depth representation of a table, and finally they were shown the human display appearing to pass through the table top in violation of the solidity of the hidden human form. Both six- and nine-month-old infants showed significantly greater recovery of attention to this final phase. This suggests that infants are able to bind a solid vertical form to human motion. In two further control experiments we presented displays that contained similar patterns of motion but were not perceived by adults as human. Six- and nine-month-old infants did not show recovery of attention when a scrambled display or an inverted human display passed through the table. Thus, the binding of a solid human form to a display in only seems to occur for upright human motion. The paper considers the implications of these findings in relation to theories of infants' developing conceptions of objects, humans and animals.     

Visual attention capacity: a review of TVA-based patient studies

Psychophysical studies have identified two distinct limitations of visual attention capacity: processing speed and apprehension span. Using a simple test, these cognitive factors can be analyzed by Bundesen's Theory of Visual Attention (TVA). The method has strong specificity and sensitivity, and measurements are highly reliable. As the method is theoretically founded, it also has high validity. TVA-based assessment has recently been used to investigate a broad range of neuropsychological and neurological conditions. We present the method, including the experimental paradigm and practical guidelines to patient testing, and review existing TVA-based patient studies organized by lesion anatomy. Lesions in three anatomical regions affect visual capacity: The parietal lobes, frontal cortex and basal ganglia, and extrastriate cortex. Visual capacity thus depends on large, bilaterally distributed anatomical networks that include several regions outside the visual system. The two visual capacity parameters are functionally separable, but seem to rely on largely overlapping brain areas.     

What is special about the index finger?: The index finger advantage in manipulating reflexive attentional shift1

Pointing with the index finger is a universal behavior. However, the functional significance of indexical pointing has not been examined empirically. We examined the efficacy of various pointing gestures in evoking viewer's attentional shifts. After viewing the gesture cue, observers quickly reported the location of a visual target. With a short cue‐target delay, reaction times were generally shorter for the target at the location where gesture cues pointed, but not with a long cue‐target delay. Moreover, the indexical pointing gesture produced a significantly larger cueing effect than the other gestures. Our control experiments indicated that the index‐finger advantage is tightly linked to the proper morphological shape (i.e. length and position of the index finger) of the indexical pointing and is not explained by the directional discriminability of the gesture. The visual system seems to use mechanisms that are partially independent of the directional discrimination of gestures, in order to quickly modulate the viewer's attention.     

光栅朝向分辨学习中存在关于45°对角线对称的镜像迁

采用光栅朝向分辨任务来探讨视知觉学习中是否存在关于45°对角线对称的镜像迁移现象。训练被试分辨15°或75°朝向3或5天,每天约1小时,训练前后测量15°、75°、45°朝向的分辨阈值。通过训练,训练朝向（15°或75°）的阈值下降,该学习效应没有迁移至45°朝向,但基本迁移到关于45°对称的朝向（75°或15°）上。这提示,视知觉学习可能发生在中间视皮层,该皮层同时具有一定的朝向特异性和关于45°对角线对称的镜像迁移性     

视觉意识及其神经机制

视觉意识的神经机制是当前认知神经科学研究的热点问题之一。过去普遍认为视觉信息加工主要有两条通路:腹侧通路和背侧通路;而新近的研究表明还存在不经过初级视觉皮层(V1区)的第三条通路。高级视觉皮层、V1区和皮层下结构都对意识觉知的产生起到了相应的作用。已有的实验证据表明,意识的产生过程异常复杂,仍有很多问题值得继续深入讨论和研究。     

刺激的知觉辨认难度与大脑两半球间的分布式加工

采用半视野速示术将标准刺激在中间视野呈现,比较刺激以不同偏心视角（3.5°,5°和6.5°）在左或右视野同时呈现,以检查不同偏心视角引起比较刺激知觉辨认难度的改变对汉字大写数字奇－偶概念同/异判断任务在大脑两半球间分布式加工的影响。结果显示：随偏心视角的增大正确反应时和错误百分数均显著提高;三种视角条件下左右手的正确反应时均有明显的右视野（左半球）优势;3.5°视角右视野（左半球）呈现时右手反应明显快于左手,5°视角右视野（左半球）与左视野（右半球）呈现时均为右手反应明显快于左手,6.5°视角右视野（左半球）与左视野（右半球）呈现时均为左手反应明显快于右手。这些结果提示：本研究条件下只有比较刺激在6.5°偏心视角呈现时刺激和反应可能出现大脑两半球间分布式加工,3.5°和5°视角呈现时可能为左半球单独加工。6.5°视角刺激呈现的分布加工明显由于大视角呈现时比较刺激辨认难度与注意要求的提高所致。