Extraversion modulates functional connectivity hubs of resting‐state brain networks

Personality dimension extraversion describes individual differences in social behaviour and socio‐emotional functioning. The intrinsic functional connectivity patterns of the brain are reportedly associated with extraversion. However, whether or not extraversion is associated with functional hubs warrants clarification. Functional hubs are involved in the rapid integration of neural processing, and their dysfunction contributes to the development of neuropsychiatric disorders. In this study, we employed the functional connectivity density (FCD) method for the first time to distinguish the energy‐efficient hubs associated with extraversion. The resting‐state functional magnetic resonance imaging data of 71 healthy subjects were used in the analysis. Short‐range FCD was positively correlated with extraversion in the left cuneus, revealing a link between the local functional activity of this region and extraversion in risk‐taking. Long‐range FCD was negatively correlated with extraversion in the right superior frontal gyrus and the inferior frontal gyrus. Seed‐based resting‐state functional connectivity (RSFC) analyses revealed that a decreased long‐range FCD in individuals with high extraversion scores showed a low long‐range functional connectivity pattern between the medial and dorsolateral prefrontal cortex, middle temporal gyrus, and anterior cingulate cortex. This result suggests that decreased RSFC patterns are responsible for self‐esteem, self‐evaluation, and inhibitory behaviour system that account for the modulation and shaping of extraversion. Overall, our results emphasize specific brain hubs, and reveal long‐range functional connections in relation to extraversion, thereby providing a neurobiological basis of extraversion.     

Neuroimaging and Occupational Therapy: Bridging the Gap to Advance Rehabilitation in Developmental Coordination Disorder

Developmental coordination disorder (DCD) is a neurodevelopmental disorder characterized by poor motor skills that interfere with a child's ability to perform everyday activities. Little is known about the neural mechanisms that implicate DCD, making it difficult to understand why children with DCD struggle to learn motor skills and selecting the best intervention to optimize function. Neuroimaging studies that utilize magnetic resonance imaging techniques have the capacity to play a critical role in helping to guide clinicians to optimize functional outcomes of children with DCD using evidence-based rehabilitation interventions. The authors' goal is to describe how neuroimaging research can be applied to occupational therapy and rehabilitation sciences by highlighting projects that are at the forefront of the field and elucidate future directions.     

A method for detailed movement pattern analysis of tadpole startle response

Prolonged space flight, specifically microgravity, presents a problem for space exploration. Animal models with altered connections of the vestibular ear, and thus altered gravity sensation, would allow the examination of the effects of microgravity and how various countermeasures can establish normal function. We describe an experimental apparatus to monitor the effects of ear manipulations to generate asymmetric gravity input on the tadpole escape response. To perform the movement pattern analysis, an imaging apparatus was developed that uses a high‐speed camera to obtain time‐resolved, high‐resolution images of tadpole movements. Movements were recorded in a temperature‐controlled test chamber following mechanical stimulation with a solenoid actuator, to elicit a C‐start response. Temperature within the test cell was controlled with a recirculating water bath. Xenopus laevis embryos were obtained using a standard fertilization technique. Tadpole response to a controlled perturbation was recorded in unprecedented detail and the approach was validated by describing the distinct differences in response between normal and one‐eared tadpoles. The experimental apparatus and methods form an important element of a rigorous investigation into the response of the tadpole vestibular system to mechanical and biochemical manipulations, and can ultimately contribute to improved understanding of the effects of altered gravity perception on humans.     

运动技能水平与躯体感觉输入对运动表象的影响

运动表象质量与运动技能水平有关,运动表象质量随着运动技能水平的提高而上升。器械使用可使人脑产生可塑性改变,使用者会将器械纳入身体图式。然而,两者影响运动表象的神经心理机制还不清楚。本研究采用功能性磁共振成像探析篮球运动员与新手在不同持球条件下表象投篮时脑功能活动的差异。结果表明运动员表象质量较好,镜像神经系统激活高于新手;持球条件下运动员表象质量显著高于不持球条件下,镜像神经系统激活程度显著低于不持球条件下。研究说明持器械可以显著提高运动员的表象质量,器械使用带来镜像神经系统的可塑性变化。     

EEG and fMRI agree: Mental arithmetic is the easiest form of imagery to detect

fMRI and EEG during mental imagery provide alternative methods of detecting awareness in patients with disorders of consciousness (DOC) without reliance on behaviour. Because using fMRI in patients with DOC is difficult, studies increasingly employ EEG. However, there has been no verification that these modalities provide converging information at the individual subject level. The present study examined simultaneous EEG and fMRI in healthy volunteers during six mental imagery tasks to determine whether one mental imagery task generates more robust activation across subjects; whether activation can be predicted from familiarity with the imagined activity; and whether EEG and fMRI converge upon the same conclusions about individual imagery performance. Mental arithmetic generated the most robust activation in the majority of subjects for both EEG and fMRI, and level of activation could not be predicted from familiarity, with either modality. We conclude that overall, EEG and fMRI agree regarding individual mental imagery performance.     

自上而下注意控制的脑成像研究进展

自上而下的注意控制是调节人类各种认知活动的一种重要执行功能,本文从三个方面总结了该领域内脑成像研究的新进展：(1)自上而下注意控制的脑机制;(2)不同种类的注意控制脑机制的一致性;(3)自上而下的注意控制对其它皮层中神经活动的影响。     

A comparison of human aggression committed by groups and individuals: An interindividual-intergroup discontinuity

Experimental research comparing aggressive behavior committed by groups and individuals is important but sparse. This experiment compared aggressive behavior (i.e., amount of hot sauce allocated for others to consume) in four types of interactions: intergroup, interindividual, group-to-individual, and individual-to-group. The results revealed that intergroup interactions were significantly more aggressive than interindividual interactions. In addition, groups allocated and received significantly more hot sauce than individuals. These effects were not explained by diffusion of responsibility or trait aggressiveness. The experiment reveals two noteworthy conclusions: (1) the interindividual-intergroup discontinuity effect extends to aggressive behavior and (2) interactions in which a group is either the source or target of aggression are situational influences that can increase it.     

完善自身免疫性糖尿病胰岛炎核素显像研究及其思考

回顾和综述自身免疫性糖尿病胰岛炎核素显像技术的产生、发展过程和最新研究进展.分析系统论方法主要基本原则在该技术研究进展中的指导性作用.揭示在医学科学研究中自觉、主动地运用辨证思维方法和系统论科学方法,可以拓展研究的新思路,为深入认识、改进和创造先进技术提供有效手段、为制定研究的最佳方案及优化组合提供新途径,对促进和指导医学研究发展有极其重要的意义.     

Correlation between gray/white matter volume and cognition in healthy elderly people

This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109 community-dwelling healthy elderly individuals. We used the Information and Digit Span subtests of the Wechsler Adult Intelligent Scale-Revised as measures of semantic memory and short-term memory, respectively. We found significant positive correlations between the gray matter ratio, the percentage of gray matter volume in the intracranial volume, and performance on the Digit Span subtest, and between the regional gray matter volumes of the bilateral anterior temporal lobes and performance on the Information subtest. No significant correlations between performance on the cognitive tests and white matter volume were found. Our results suggest that individual variability in specific cognitive functions that are relatively well preserved with aging is accounted for by the variability of gray matter volume in healthy elderly subjects.     

图形型归纳推理的神经机制:一项fMRI研究

利用fMRI脑成像技术探讨图形型归纳推理的神经机制。设计了一种由图形形状和条纹方向描述的简单几何图形组成的归纳推理任务,这种图形型任务与以往研究中常用的语句型归纳推理任务是同质的。根据两个图形共享特征数量的不同设计了两种实验任务:共享两个特征(2T)和共享一个特征(1T),以休息基线(Rest)作为控制任务。2T和1T任务均为归纳推理任务,但2T任务包含知觉特征整合成分,而1T任务不包括。结果发现:与控制任务相比,归纳推理任务在前额区(BA6、9、11、46、47)、尾状核、壳核和丘脑等脑区有显著激活,反映了"前额皮层-纹状体-丘脑"通路在图形型归纳推理中的重要作用;图形型归纳推理中的知觉信息整合与右侧额下回(BA47)、双侧尾状核头部、壳核等脑区有关。