The development of grapheme-phoneme correspondence in normal and dyslexic readers

The present experiment was concerned with the development of grapheme-phoneme conversion ability in normal and reading-age matched dyslexic readers. The use of grapheme-phoneme correspondences was observed in a recognition memory task for pronounceable nonwords. The nonwords were presented in either the visual or auditory modality and had to be recognized immediately from the converse modality, thus necessitating decoding of stimuli across modalities. The use of grapheme-phoneme correspondences increased with reading age in the normal readers but not in the dyslexics. It was postulated that dyslexics have a specific difficulty in grapheme-phoneme conversion. For them an increase in reading age is attributable mainly to an increase in size of sight vocabulary.     

The developmental difference of inattentional blindness in 3-to-5-year-old preschoolers and its relationship with fluid intelligence

Preschoolers can focus on the events that they are interested in and shield other information that may still be obvious and important, and this phenomenon is termed as inattentional blindness (IB). The present study investigated the developmental differences in IB and explored its relationship with fluid intelligence in 3-to-5-year-old preschoolers. With the involvement of one hundred and thirty-five preschoolers, it was found that the IB rates decreased with age during 3-to-5-year-olds. Fluid intelligence could significantly predict the incidence of IB in 4-year-olds, which means that those with higher fluid intelligence scores experience less IB. It implied that the ability to detect unintentional stimuli increased from 3-to-5-year-olds, whereas age was an impact factor to the relationship between fluid intelligence and IB.     

绩效评价的若干问题

通过对绩效的内涵、绩效评价标准的确定、评量指标体系的构建以及多样性评量指标的整合意义与方法等四个绩效评价的最基本问题进行反思 ,提出如下观点 :(1 )对绩效进行考量时必须同时考虑时间、方式和结果三个维度。 (2 )绩效评价标准的确定应先于具体评量指标的选择 ,且应保持一定的稳定性 ,不可随意增删 ;(3 )评量指标体系的构建应本着贵精不贵多、贵明确不贵模糊、贵敏感不贵迟钝 ,贵关键不贵空泛的原则进行 ;(4)多样性评量指标是否整合需根据具体的需要而定 ,整合时要考虑评量指标本身的权重差异以及不同评价者由于对标准尺度掌握的松紧不一和评判角度不同所带来的对最终评价结果的影响。     

结节性甲状腺肿手术路径质量管理成效研究

本文通过对比分析临床路径实施前后各项质量相关指标,研究临床路径模式在精细分科部门中结节性甲状腺肿手术患者质量管理的应用成效。结果显示临床路径在质量管理过程中取得显著成效,尤其是在缩短平均住院日方面,但对于费用的控制还有待进一步提高,因此应对实施中的临床路径进行不断地持续改进,为患者提供更优质的服务。     

The structure of the State Hope Scale

The present research aimed to examine the factorial structure of the State Hope Scale (SHS). In Study 1, using confirmatory factorial analyses, two factorial structures were contrasted: a single-factor mode (representing a general hope construct) and a second-order factor model (with general hope characterized by agency and pathways). Results revealed that the two-factor model was more likely to be replicated. Furthermore, invariance analyses revealed that the two-factor structure applied equally across age groups and gender. In Study 2, the factorial structure of the SHS was evaluated again. Once more, results confirmed the superiority of the two-factor model. In addition, hope was positively linked to mental health.     

The tendency to overestimate what is visible in a planar mirror amongst adults and children

Adults hold several mistaken beliefs about simple mechanical and optical phenomena. In particular, many adults believe that they would be able to see their own image in a mirror before they are in front of it. Similarly, they expect objects to become visible in mirrors before they actually do. This overestimation of what is visible is known as the early error (Bertamini, Spooner, & Hecht, 2003). It has been suggested that incorrect models about mechanics, and therefore erroneous beliefs, develop over time, as evidenced by good performance in young children (Kaiser, McCloskey, & Proffitt, 1986). With respect to knowledge about what is visible in mirrors we report the first developmental data. We confirmed an effect for prospective University students but found no evidence of any early error in children between the age of 5 and 11. This erroneous belief about mirrors develops during the later school years when people develop a system of beliefs based on experience.     

Speech prosody and developmental dyslexia: Reduced phonological awareness in the context of intact phonological representations

Recent research indicates that awareness of the rhythmic patterns present in spoken language (i.e., prosody) may be an important and relatively overlooked predictor of reading ability. Two studies investigated the prosodic processing abilities of skilled adult readers and adults with developmental dyslexia. Participants with dyslexia showed reduced awareness of lexical and metrical stress and these skills were found to be significantly associated with, and predictive of, phonological decoding ability. In contrast, the same individuals showed normal patterns of stress based priming at magnitudes similar to controls. These results—suggesting reduced phonological awareness in the context of intact phonological representations—are consistent with recent findings reported in the domain of phonemic processing. Implications for the phonological deficit theory of dyslexia are discussed.     

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways.     

发展性计算障碍的最新研究进展

发展性计算障碍是一种影响算术技能获得的特定的学习障碍。截至目前,有关发展性计算障碍的认知与神经机制的理论尚存分歧,有关诊断与鉴别标准也未统一。近年来,对于发展性计算障碍的理论假设有从一般认知因素取向到数学特定因素取向发展的趋势。而随着脑成像技术的不断发展,对于发展性计算障碍神经机制的研究也从针对单个脑区的特异性功能发展到从功能连接网络角度进行研究。并且研究者们开始尝试开发基于数学认知基本理论的干预方法,并采用了利用生物技术手段的新方法。基因-脑-行为的整合研究将有助于全面揭示发展性计算障碍的发生机制,而建立在系统理论基础上经过科学评估的干预手段将可能有效促进障碍者的计算能力。     

The relation of learning disabilities to the long-term outcomes of concussion

ObjectiveThis study sought to cross-sectionally evaluate the relation between learning disorders (LD) and long-term concussion outcomes.MethodSeventy-three asymptomatic male university athletes (23 history of concussion with LD; 24 history of concussion no LD; 26 controls) completed the Beck Depression Inventory-2 (BDI-II), the Profile of Mood States (POMS), the Cogstate battery, and an Oddball task during which event-related brain potentials were recorded.ResultsConcussed athletes with LD exhibited greater depressive symptoms (BDI-II), greater total mood disturbance (POMS), decreased accuracy on the One-Card Learning and the N-back task (Cogstate), decreased accuracy on the Oddball task, and reduced ERN amplitude relative to both the concussed athletes without a LD and controls. Concussed athletes with LD also exhibited prolonged P3 latency relative to controls. Irrespective of LD, concussed athletes exhibited increased anger-hostility and decreased Pe amplitudes relative to controls. No differences were observed in P3a amplitude or latency.ConclusionHaving LD may be a significant factor moderating the neurophysiological, cognitive and psycho-affective outcomes of concussion, and may explain a significant portion of the persistent deficits observed by researchers and clinicians.