A prospective naturalistic study of the impact of an intensive medical treatment on the social behavior of child and adolescent cancer patients

The impact of intensive chemotherapy and prolonged hospitalization on the social behavior of child and adolescent cancer patients was assessed. Twenty-three patients, aged 18 months to 21 years, were observed while they received chemotherapy in a protected environment or in a regular hospital room. Single-subject analyses were used to examine changes on six behaviors in relation to changes in physiological status. Fourteen patients showed significant change in the frequency of at least one behavior. Play and sleep were the behaviors most likely to change. The changes began to occur as patients experienced the systemic toxic effects of the drugs, although a dissipation of drug toxicity generally was not accompanied by a corresponding behavior change. The findings are discussed in relation to age-developmental and interindividual heterogeneity in response to treatment.     

Father and mother contributions to family functioning when the child has a mental delay

Less is known about the father's than the mother's role in family adaptation to children with disabilities. The purpose of this study was to examine relationships of both father and mother use of coping strategies and perceptions of the child with measures of family functioning style. Subjects were 26 families of 30-month-old children with a mental delay and a comparison group of 26 families of same-aged children with no delay. Functioning style for study families showed a balance of cohesion and adaptability; comparison families were more chaotically flexible on the adaptability scale. Mothers and fathers agreed on family functioning style. Study parents made the greatest use of external coping strategies, while in both groups mothers used more external and fathers more internal coping strategies. Relationships between coping and family functioning varied by parent and by group. Results suggest the need for further exploration of the separate needs of fathers and mothers in maintaining balanced family functioning.     

Coding infant engagement in the Face-to-Face Still-Face paradigm using deep neural networks

BackgroundThe Face-to-Face Still-Face (FFSF) task is a validated and commonly used observational measure of mother-infant socio-emotional interactions. With the ascendence of deep learning-based facial emotion recognition, it is possible that common complex tasks, such as the coding of FFSF videos, could be coded with a high degree of accuracy by deep neural networks (DNNs). The primary objective of this study was to test the accuracy of four DNN image classification models against the coding of infant engagement conducted by two trained independent manual raters.Methods68 mother-infant dyads completed the FFSF task at three timepoints. Two trained independent raters undertook second-by-second manual coding of infant engagement into one of four classes: 1) positive affect, 2) neutral affect, 3) object/environment engagement, and 4) negative affect.ResultsTraining four different DNN models on 40,000 images, we achieved a maximum accuracy of 99.5% on image classification of infant frames taken from recordings of the FFSF task with a maximum inter-rater reliability (Cohen's κ-value) of 0.993.LimitationsThis study inherits all sampling and experimental limitations of the original study from which the data was taken, namely a relatively small and primarily White sample.ConclusionsBased on the extremely high classification accuracy, these findings suggest that DNNs could be used to code infant engagement in FFSF recordings. DNN image classification models may also have the potential to improve the efficiency of coding all observational tasks with applications across multiple fields of human behavior research.     

绩效评价的若干问题

通过对绩效的内涵、绩效评价标准的确定、评量指标体系的构建以及多样性评量指标的整合意义与方法等四个绩效评价的最基本问题进行反思 ,提出如下观点 :(1 )对绩效进行考量时必须同时考虑时间、方式和结果三个维度。 (2 )绩效评价标准的确定应先于具体评量指标的选择 ,且应保持一定的稳定性 ,不可随意增删 ;(3 )评量指标体系的构建应本着贵精不贵多、贵明确不贵模糊、贵敏感不贵迟钝 ,贵关键不贵空泛的原则进行 ;(4)多样性评量指标是否整合需根据具体的需要而定 ,整合时要考虑评量指标本身的权重差异以及不同评价者由于对标准尺度掌握的松紧不一和评判角度不同所带来的对最终评价结果的影响。     

Traumatic Brain Injury in School-Age Children Academic and Social Outcome

School-aged children with a traumatic brain injury (TBI) require extraordinary effort and energy from individuals in their school, home, and community. The purpose of this study was to examine the academic, behavioral, and social outcomes of a cohort of children and adolescents following TBI. A comprehensive assessment of cognitive functioning, achievement, and adaptive behavior was administered to 43 school-aged children 2 years after their TBI. Premorbid functioning for each participant was obtained from state-mandated test scores assessed prior to the TBI. The predictive utility of premorbid functioning, TBI severity, and age at injury were examined. Findings revealed that premorbid functions were significant predictors of reading and spelling achievement and adaptive functioning. Severity of injury was predictive of adaptive functioning. Implications of findings include program development, reintegration into school, and educating parents and teachers.     

Tangled webs: tracing the connections between genes and cognition

The rise of molecular genetics is having a pervasive influence in a wide variety of fields, including research into neurodevelopmental disorders like dyslexia, speech and language impairments, and autism. There are many studies underway which are attempting to determine the roles of genetic factors in the aetiology of these disorders. Beyond the obvious implications for diagnosis, treatment and understanding, success in these efforts promises to shed light on the links between genes and aspects of cognition and behaviour. However, the deceptive simplicity of finding correlations between genetic and phenotypic variation has led to a common misconception that there exist straightforward linear relationships between specific genes and particular behavioural and/or cognitive outputs. The problem is exacerbated by the adoption of an abstract view of the nature of the gene, without consideration of molecular, developmental or ontogenetic frameworks. To illustrate the limitations of this perspective, I select two cases from recent research into the genetic underpinnings of neurodevelopmental disorders. First, I discuss the proposal that dyslexia can be dissected into distinct components specified by different genes. Second, I review the story of the FOXP2 gene and its role in human speech and language. In both cases, adoption of an abstract concept of the gene can lead to erroneous conclusions, which are incompatible with current knowledge of molecular and developmental systems. Genes do not specify behaviours or cognitive processes; they make regulatory factors, signalling molecules, receptors, enzymes, and so on, that interact in highly complex networks, modulated by environmental influences, in order to build and maintain the brain. I propose that it is necessary for us to fully embrace the complexity of biological systems, if we are ever to untangle the webs that link genes to cognition.     

Houston Conference: Need for More Fundamental Knowledge in Neuropsychology

Two training models in neuropsychology have been recently proposed (Guidelines of the INS-Division 40 Task Force on Education, Accreditation, and Credentialing, Clin. Neuropsychol. 1: 29–34, 1987; Hannay, H. J. et al., Arch. Clin. Neuropsychol. 13: 157–250, 1998). When comparing both educational models, similarities but also differences are found. According to the Houston Conference model—but not to the former model—neuropsychology represents a specialty of psychology. In the Houston Conference training model, applied knowledge is overtly emphasized, whereas fundamental or basic knowledge in neuropsychology appears weak. The proposed program does not seem to provide sufficient emphasis and background knowledge in (1) History of neuropsychology, (2) Neuropsychological syndromes, and (3) Neuropsychology theory.     

Differences in postural control and movement performance during goal directed reaching in children with developmental coordination disorder

Poor upper-limb coordination is a common difficulty for children with developmental coordination disorder (DCD). One hypothesis is that deviant muscle timing in proximal muscle groups results in poor postural and movement control. The relationship between muscle timing, arm motion and children's upper-limb coordination deficits has not previously been studied. The aim of this study was to investigate the relationship between functional difficulties with upper-limb motor skills and neuromuscular components of postural stability and coordination. Sixty-four children aged 8-10 years, 32 with DCD and 32 without DCD, participated in the study. The study investigated timing of muscle activity and resultant arm movement during a rapid, voluntary, goal-directed arm movement. Results showed that compared to children without DCD, children with DCD took significantly longer to respond to visual signals and longer to complete the goal-directed movement. Children with DCD also demonstrated altered activity in postural muscles. In particular, shoulder muscles, except for serratus anterior, and posterior trunk muscles demonstrated early activation. Further, anterior trunk muscles demonstrated delayed activation. In children with DCD, anticipatory function was not present in three of the four anterior trunk muscles. These differences support the hypothesis that in children with DCD, altered postural muscle activity may contribute to poor proximal stability and consequently poor arm movement control when performing goal-directed movement. These results have educational and functional implications for children at school and during activities of daily living and leisure activities and for clinicians assessing and treating children with DCD.     

认知神经心理学理论研究与失语症治疗的关系

该文介绍了词语产出的加工阶段以及在获得性语言障碍病人（失语症病人）身上这些阶段可能的损伤情况。文中特别介绍了两例词汇提取障碍病人的治疗,这不仅有助于了解该障碍,更有助于了解其潜在的理论问题。第一个案例关注使用不同的任务治疗词汇提取障碍,评估治疗效果,探究任务产生作用的原理。第二个案例使用词汇提取障碍的治疗方法探讨一个充满争议的问题：同音词（如,pour/paw）在词汇产出过程中是共用一个语音表征还是各自单独表征