Cascade effects on the irradiation stability of amorphous SiOC

We studied the heavy ion radiation tolerance of amorphous silicon oxycarbide (SiOC) alloys by in situ Kr ion irradiation within a transmission electron microscopy. The amorphous SiOC thin films were grown via co-sputtering from SiO₂ and SiC targets on a surface-oxidized Si (100) substrate. These films were irradiated by 1 MeV Kr ions at both room temperature and 300 °C with damage levels up to 5 displacements per atom (dpa). TEM characterization shows no sign of crystallization, void formation or segregation in all irradiated samples. Our findings suggest that SiOC alloys are a class of promising radiation tolerant materials.     

Hydrogen-assisted damage in austenite/martensite dual-phase steel

For understanding the underlying hydrogen embrittlement mechanism in transformation-induced plasticity steels, the process of damage evolution in a model austenite/martensite dual-phase microstructure following hydrogenation was investigated through multi-scale electron channelling contrast imaging and in situ optical microscopy. Localized diffusible hydrogen in martensite causes cracking through two mechanisms: (1) interaction between {1?1?0}_M localized slip and {1?1?2}_M twin and (2) cracking of martensite–martensite grain interfaces. The former resulted in nanovoids along the {1?1?2}_M twin. The coalescence of the nanovoids generated plate-like microvoids. The latter caused shear localization on the specific plane where the crack along the martensite/martensite boundary exists, which led to additional martensite/martensite boundary cracking.     

弯曲时空理论与生物体DNA双螺旋结构

对爱因斯坦的"弯曲时空"理论与生物体DNA双螺旋结构的相关性进行了哲理性思考:控制生命时间程序的生物钟基因编码及调控细胞分裂的正、负向基因对应表达的严格时间程序,在DNA双螺旋结构上可能具有"时空弯曲"的原理.地球上不同经纬度地区的时间流行病学特征应该具有相对同时性.     

成瘾相关记忆的表观遗传学机制 ——药物成瘾研究的新视角

成瘾相关记忆长期性的脑机制一直是药物成瘾研究领域的难点与热点,该文简要介绍了成瘾记忆长期性分子机制的研究脉络,提示表观遗传学修饰可能是研究药物成瘾的新视角。成瘾药物可以调节染色体不同亚型组蛋白乙酰化水平,不同基因DNA的甲基化程度从而改变染色体的空间结构,进而调节基因的表达导致成瘾,特别是DNA甲基化改变的相对的稳定性可能是成瘾记忆长期存在的分子基础。记忆再巩固过程中学习记忆相关脑区的记忆促进基因与记忆抑制基因的表观遗传学改变可能是未来研究的新趋势     

Socrates on How Wrongdoing Damages the Soul

There has been little scholarly attention given to explaining exactly how and why Socrates thinks that wrongdoing damages the soul. But there is more than a simple gap in the literature here, we shall argue. The most widely accepted view of Socratic moral psychology, we claim, actually leaves this well-known feature of Socrates’ philosophy absolutely inexplicable. In the first section of this paper, we rehearse this view of Socratic moral psychology, and explain its inadequacy on the issue of the damaging consequences of wrongdoing. We then go on to provide our own account of the way in which injustice damages the soul, and then draw conclusions about how Socratic moral psychology should be understood.     

心理应激与DNA损害

心理应激不仅能使人的行为特征发生变化,而且也能使人的生理状况发生改变,因此,被认为是某些身心疾病的诱因。在此过程中,DNA损害是心理应激造成的最终结果之一。有关DNA损害,虽然以往的研究者以人或动物为对象进行了一系列急性应激和慢性应激的实验研究,但是,心理应激是如何造成DNA损害的过程还不清楚,具体的生理心理机制还未阐明。该文利用健康心理学提出的理论模型对此进行了分析,阐述了心理应激与DNA损害之间联系的可能的机制,强调了氧化应激在这一过程中的重要作用。同时,为临床制订预防疾病的干预措施提供了思路     

Reviews

Books reviewed: Science and Theology: An Introduction, by JohnPolkinghorne Genesis, Genes, and God: Values and Their Origins in Naturaland Human History, by Holmes Rolston, III Playing God? Genetic Determinism and Human Freedom, by Ted Peters Green Space, Green Time: The Way of Science, by Connie Barlow Reconstructing Nature: The Engagement of Science and Religion , by John Brooke and GeoffreyCantor Whatever Happened to the Soul? Scientific and Theological Portraits ofHuman Nature, Edited by Warren S. Brown, Nancey Murphy, and H.Newton Malony The Turn of the Millennium: An Agenda for Christian Religion in an Age of Science, by Jeffrey G. Sobosan God without the Supernatural: A Defense of Scientific Theism, by Peter Forrest Religion and Creation, by Keith Ward     

中美医疗损害责任制度改革之比较研究

医疗损害责任已成为现代社会普遍的医疗法律问题。中美两国医疗损害责任制度改革正朝着相反的方向发展。诉讼机制在美国医疗损害责任中的作用由强变弱，医疗诉讼起诉由易变难，医疗损害赔偿由不限制到相对限制，行政管理式的医疗过错责任制度由无到逐渐提议。我国医疗损害责任制度改革恰恰相反，即诉讼制度的作用由弱变强、医疗损害起诉由难到易，医疗损害赔偿由相对限制到不限制、行政管理式的医疗过错责任制度从有到无。我国医疗损害责任制度的改革趋势值得反思。建议借鉴美国医疗损害责任制度改革的经验。     

DIVINE DNA? “SECULAR” AND “RELIGIOUS” REPRESENTATIONS OF SCIENCE IN NONFICTION SCIENCE TELEVISION PROGRAMS

Through analysis of film sequences focusing on DNA in two British Broadcasting Corporation nonfiction science television programs, Wonders of Life and Bang! Goes the Theory, first broadcast in 2013, contrasting “religious” and “secular” representations of science are identified. In the “religious” portrayal, immutable scientific knowledge is revealed to humanity by nature with minimal human intervention. Science provides a creation story, “explanatory omnicompetence,” and makes life existentially meaningful. In the “secular” portrayal, scientific knowledge is changeable; is produced through technical skill in expert communities; and is ambiguous, potentially positive and negative for society. Television representations of science affect audience understandings, and this is particularly the case for nonfiction representations of science, as they are likely to be “taken more seriously” than fictional representations. The consequences of the “religious” representation of science are discussed, and it is argued that a widespread understanding of science as presented in the religious portrayal would negatively impact democracy.