DNA研究的历史带给我们的启示

自然科学发展日新月异。墨守成规的传统思维模式常常是羁绊研究工作停滞不前的主要障碍。通过纵观DNA双螺旋结构的研究历程,认识到实事求是的态度是确立正确研究方向的基础,而全方位、多视角、多学科交叉的开放性思维模式给科学研究带来了更宽阔的途径。     

定量组织速度成像评价酒精性心肌损害左室功能的价值

为了评估定量组织速度成像(QTVI)在评价大量饮酒后心肌损害左室功能改变方面的价值,我们对饮酒量符合酒精性心肌病诊断标准患者21例(B组,每日饮白酒≥150g或啤酒4瓶,每周6天~7天,10年以上),30例健康志愿者(A组,正常对照组)进行常规超声参数及QTVI参数测定,包括:二尖瓣环收缩期峰值速度(Vs)、舒张早期运动速度(Ve)、舒张晚期运动速度(Va)等。结果显示,B组常规各超声参数与A组比较差异有显著性统计学意义(P0.01)。QTVI参数与A组比较Va减低(P0.05),Vs、Ve、Ve/Va显著减低(P0.01)。提示QTVI技术能够有效地评估酒精性心肌损害病左室功能的改变。     

Interactions of space and language: Insights from the neglect syndrome

The current article speculates about the interrelations between space and language from the perspective of the neglect syndrome. Various conflicting findings are reviewed and the effect of cultural factors is strongly emphasised. Current scientific literature describes relationships between space and language; however, the available data render it difficult to conclude whether it is the primacy of spatial representations or the complex two‐way interaction between linguistic and spatial representations that determines the nature of cognitive processing. It is hoped that studying the neglect syndrome will provide a solution to this problem. Finally, directions for future research are provided that requires bridging the gap between cognitive theorising and neuroscientific approaches.     

Does exercise-induced muscle damage impair subsequent motor skill learning?

Motor skill learning is a fundamental aspect of human behavior based on the calibration of internal models via sensory information such as proprioception. Some conditions, as exercise-induced muscle damage (EIMD), disrupt proprioceptive information, and may cause learning impairment. Such possible relation between EIMD and motor skill learning has not yet been investigated and it is the aim of this study. For this purpose, thirty male university students (19.3 ± 1.8 years) were equally assigned to two groups: EIMD and CON group. The EIMD group received a treatment to induce muscle damage consisting of a weight lifting protocol directed to the agonist muscles related to the task prior to the pretest and to the learning sessions. EIMD was verified and compared between groups and along the process (0–168 h) by means of the degree of delayed onset muscle soreness (DOMS), perceived total quality recovery and maximal isometric strength (MIS). To investigate motor skill learning, both groups practiced a dart throwing task for four sessions with 150 trials in each session. Recovery status and DOMS were recovered at 96 h in the EIMD group, and MIS was not recovered throughout 168 h. In contrast, muscle damage parameters were not altered across 168 h in the CON group. Accuracy and consistency were compared within and between groups in a pretest posttest design. The EIMD group showed less accurate and consistent results on the long term (delayed posttest). Results confirmed our hypothesis that EIMD, a common condition in sports and in rehab practices, may hinder motor skill learning, possibly due to neurological aspects such as proprioceptive information, its relation to central nervous system reorganization and internal model consolidation.     

反社会行为的遗传基础:基因多态性和DNA甲基化

反社会行为是受遗传与环境共同影响的不良行为。分子遗传学和神经生物学的研究发现,基因以基因多态性和DNA甲基化的方式影响脑结构、功能及脑内神经递质的产生和释放,进而影响反社会行为的发生发展。本文从基因多态性和DNA甲基化两方面整理了5-HTT、MAOA、OXTR等8个候选基因与反社会行为的关联。并提出未来研究需进一步探讨基因、脑和神经递质对反社会行为的联合作用。同时,扩展多基因位点、基因多态性与DNA甲基化、积极环境与基因交互作用对反社会行为影响的研究,以全面探索反社会行为发生的遗传基础,进而更加有效的预防反社会行为。     

反社会行为的遗传基础:基因多态性和DNA甲基化

反社会行为是受遗传与环境共同影响的不良行为。分子遗传学和神经生物学的研究发现,基因以基因多态性和DNA甲基化的方式影响脑结构、功能及脑内神经递质的产生和释放,进而影响反社会行为的发生发展。本文从基因多态性和DNA甲基化两方面整理了5-HTT、MAOA、OXTR等8个候选基因与反社会行为的关联。并提出未来研究需进一步探讨基因、脑和神经递质对反社会行为的联合作用。同时,扩展多基因位点、基因多态性与DNA甲基化、积极环境与基因交互作用对反社会行为影响的研究,以全面探索反社会行为发生的遗传基础,进而更加有效的预防反社会行为。     

基因芯片技术的出现及对生命科学发展的影响

对于复杂的生命系统,基因芯片技术以一种综合、全面、系统的观点来研究生命现象,打破了以往“一种疾病一个基因”的研究模式,它充分利用了生命科学、信息学等当今带头科学的成果,已成为后基因组时代生命科学研究强有力的工具。随着基因芯片技术的出现, 白质芯片等类似新技术也相继发明,生命科学研究的思维方式正经历一场深刻的改革,同时加速了生物信息、基因工业时代的到来。     

Duty to Re-Contact: A Study of Families at Risk for Fragile X

DNA testing for Fragile X syndrome is now routinely available through a large number of diagnostic laboratories. We have surveyed individuals from British Columbia Fragile X families identified prior to the availability of DNA testing for FMR1 to determine if they are subsequently receiving information about DNA testing. Of the 78 individuals first seen before the cloning of the FMR1 gene, 39 (50%) had not been seen in the clinic to discuss DNA testing. We initiated a contact program with these 39 patients to determine their interest in DNA testing. Contact was made with 28 individuals, 20 of whom stated interest in testing either for themselves or for a relative. Patient opinions about DNA testing were assessed through questionnaires. In those individuals who stated an interest in DNA testing, the most common reason for wishing testing was to provide information to children or grandchildren. The most common disadvantages of testing indicated by this group were that they had finished their families and that they felt the test would not have a direct impact. The most common reasons individuals were not interested in DNA testing were that there were no family members appropriate to test and that the respondent had completed his or her family. DNA testing has been performed for 13 of the 28 (46%) contacted individuals and/or at least one relative. In view of the high level of interest for testing in families who had not been seen since the cloning of the FMR1 gene, we feel that FMR1 screening programs should include actively contacting previously seen individuals.     

THE RELIGION OF A SCIENTIST: EXPLORATIONS INTO REALITY (RELIGIO PHILOSOPHI NATURALIS)

Abstract. Sir Thomas Browne's reflection on the synthesis between his Christian religion and his practice as a medical doctor, made over three centuries ago, leads into reflections on the present relation between religion and science in the personal experience of the writer. An account is given of how the actual practice of scientific investigation led the author to theistic inferences and how the study of DNA provoked questions concerning reductionism and emergence. This evoked the need for a map of knowledge, and an attempt is presented in a figure which also serves to clarify what kind of realistic reference is involved in both scientific and humanistic contexts–especially with respect to personal language. Theological investigations thereby receive at least provisional legitimization and, with this encouragement, the article pursues the questions of the nature of the divine Source ("God") of the world's being and becoming, of God's interaction and communication with the world, especially with human beings in that world. The penultimate section outlines why the writer considers an explicit communication from God to humanity in Jesus of Nazareth is coherent with the foregoing and what this implies for human fulfillment, individually and corporately. The article concludes with a plea for humility before God and nature in our inquiries in the spirit both of Sir Thomas Browne and of the arch "agnostic" T. H. Huxley.     

线方向判断测验在神经内,外科临床的应用与评价

对200名正常人及168例脑损害病人分别进行了线方向判断测验的测查。发现在对照组中,年龄、性别、文化水平对测验成绩均有一定的影响,尤以文化水平的影响最为显著。各病种组与对照组比较,发现脑梗塞组与脑肿瘤组成绩比外伤组和血管畸形组为差。同时还发现所有病种组右脑损害患者分数均低于左脑损害患者。