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ObjectiveThe influence of psychoactive substances on driving performance and traffic safety has been extensively studied. Research on the influence of alcohol at the control level of behaviour (i.e. automated processes) has been well established and has shown that the ability to operate a vehicle decreases with rising alcohol levels. However, results one level higher at the manoeuvring level (i.e. conscious processes), are inconsistent. The current study aimed to replicate findings on the influence of alcohol on the control level of behaviour and investigate effects on the manoeuvring level in order to find suitable measures to assess driving impairment.MethodThe study was double-blind, placebo-controlled with a counterbalanced treatment order and a two-way crossover design. Thirty participants performed tasks in a driving simulator under the influence of alcohol (0.5‰) and a placebo. In the driving tasks the control level of behaviour (swerving, average speed, and speed variation) was investigated, as well as the manoeuvring level of behaviour (distance to other traffic during an overtaking manoeuvre, reaction time to a traffic light turning amber, and response to a suddenly merging car).ResultsAs expected, alcohol affected the control level of behaviour negatively. Participants swerved more and showed more speed variation after alcohol intake. The manoeuvring level of driving behaviour was also affected by alcohol. The distance to other drivers during an overtaking manoeuvre was smaller under the influence of alcohol. Results on reaction time were however less straightforward. Reaction time increased significantly under the influence of alcohol when reacting to a traffic light but not in reaction to a car unexpectedly merging into traffic. When analysing behaviour in reaction to these different events in more detail it became clear that they were responded to in varying manners, making it difficult to find an average impairment measure.ConclusionsThe deteriorating effect of alcohol at the control level of driving behaviour was replicated, confirming the suitability of the standard deviation of lateral position and the variation in speed as measures of impairment. At the manoeuvring level, the kept distance to the leading car during an overtaking manoeuvre appeared to be a suitable measure to assess impairment as well as reaction time to a traffic light. The current study also confirms the difficulties in evaluating complex driving behaviour and the need for more research on this subject.  相似文献   
184.
For the fixed-effects three-parameter logistic model in item response theory, the necessary and sufficient condition of the model identification is presented synthesizing known results. An optimal transformation of parameters for model identification in Maris's unidentified case to remove or reduce the skewness of abilities is shown. In many cases, the vanishing skewnesses are obtained in the possible range of transformation for parameters with some improvements in the test response and information functions.  相似文献   
185.
Shared care between parents and grandparents is common in Asian cultures. This cocare practice provides many benefits to families but is also particularly complex, as both parents and grandparents must simultaneously fulfill their roles as cocaregivers as well as maintain their relationship with each other. This study aims to explore the determinants of coparenting relationships between parents and grandparents in Vietnam. Data were collected from 501 Vietnamese parents whose aging parents are active carers for their children. The results indicated that grandparent psychological control and parent–grandparent quality of communication explain the largest variance in both parent–grandparent coparenting conflict and cooperation. The results suggest that parenting interventions aimed at the Asian cultures, where grandparent care is common, may benefit from the inclusion of a content focus on promoting the coparenting relationship between parents and grandparents.  相似文献   
186.
Latent variable modeling in heterogeneous populations   总被引:20,自引:0,他引:20  
Common applications of latent variable analysis fail to recognize that data may be obtained from several populations with different sets of parameter values. This article describes the problem and gives an overview of methodology that can address heterogeneity. Artificial examples of mixtures are given, where if the mixture is not recognized, strongly distorted results occur. MIMIC structural modeling is shown to be a useful method for detecting and describing heterogeneity that cannot be handled in regular multiple-group analysis. Other useful methods instead take a random effects approach, describing heterogeneity in terms of random parameter variation across groups. These random effects models connect with emerging methodology for multilevel structural equation modeling of hierarchical data. Examples are drawn from educational achievement testing, psychopathology, and sociology of education. Estimation is carried out by the LISCOMP program.Presidential address delivered at the Psychometric Society meetings in Los Angeles, USA and Leuven, Belgium, July 1989. The research was supported by Grant No. SES-8821668 from the National Science Foundation and by Grant No. OERI-G-86-003 from the Office for Educational Research and Improvement, Department of Education. I thank Leigh Burstein, Mike Hollis, Linda Muthén, and Albert Satorra for helpful discussions and Tammy Tam, Jin-Wen Yang, Suk-Woo Kim, and Lynn Short for computational assistance. Designs were created by Arlette Collier, Rita Ling and Jennifer Edic-Bryant.  相似文献   
187.
The recommendation to base the analysis of multi-wave data upon explicit models for change is advocated. Several univariate and multivariate models are described, which emerge from an interaction between the classical test theory and the structural equation modeling approach. The resulting structural models for analyzing change reflect in some of their parameters substantively interesting aspects of intra- and interindividual change in follow-up studies. The models are viewed as an alternative to an ANOVA-based analysis of longitudinal data, and are illustrated on data from a cognitive intervention study of old adults (Bakes et al , 1986). The approach presents a useful means of analyzing change over time, and is applicable for purposes of (latent) growth curve analysis when analysis of variance assumptions are violated (e.g., Schaie & Hertzog, 1982; Morrison, 1976).  相似文献   
188.
东莨菪碱所致记忆障碍的脑内突触机制   总被引:18,自引:0,他引:18  
研究问题是东莨菪碱所致记忆障碍的脑内突触机制,在东莨菪碱所致记忆障碍模型上定量分析屯小鼠海马CA3区GrayI突触界面结构参数的变化。  相似文献   
189.
Maximum likelihood estimation of item parameters in the marginal distribution, integrating over the distribution of ability, becomes practical when computing procedures based on an EM algorithm are used. By characterizing the ability distribution empirically, arbitrary assumptions about its form are avoided. The Em procedure is shown to apply to general item-response models lacking simple sufficient statistics for ability. This includes models with more than one latent dimension.Supported in part by NSF grant BNS 7912417 to the University of Chicago and by SSRC (UK) grant HR6132 to the University of Lancaster.We are indebted to Mark Reiser and Robert Gibbons for computer programming. David Thissen clarified a number of points in an earlier draft.  相似文献   
190.
Many authors have reported that the development of programs for producing durable extra-therapy responding lags behind the development of programs for producing initial behavior change. In Experiment I, responding was recorded continuously in both the therapy and extra-therapy settings. The results showed that one child did not generalize to the extra-therapy setting, but that other children did. However, for the children who generalized, extra-therapy responding was not maintained. Therefore, in Experiment II two variables affecting the durability of extra-therapy responding were assessed and found to be influential: (a) the use of partial reinforcement schedules in the original treatment environment; and (b) the presence of noncontingent reinforcers in the extra-therapy environment. The results suggest that there are two distinct parameters of extra-therapy responding: generalization and maintenance. A technology for producing durable extra-therapy responding is discussed in terms of different treatment procedures required for different deficits in extra-therapy responding.  相似文献   
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