Conducting clinical research in Polish conditions

This paper comments on Polish legal guarantees for diseased persons with reference to the hazards that accompany experimental treatment. While acknowledging that participation in a clinical research program provides patients with additional opportunities for advanced treatment, the paper also points out that systems for monitoring patients participating in experimental treatment require improvement. This paper was presented at the 6th International Bioethics Conference on the subject of ‘The Responsible Conduct of Basic and Clinical Research’, held in Warsaw, Poland, 3–4 June 2005.     

A comparison of masking by visual and transcranial magnetic stimulation: implications for the study of conscious and unconscious visual processing

Visual stimuli as well as transcranial magnetic stimulation (TMS) can be used: (1) to suppress the visibility of a target and (2) to recover the visibility of a target that has been suppressed by another mask. Both types of stimulation thus provide useful methods for studying the microgenesis of object perception. We first review evidence of similarities between the processes by which a TMS mask and a visual mask can either suppress the visibility of targets or recover such suppressed visibility. However, we then also point out a significant difference that has important implications for the study of the time course of unconscious and conscious visual information processing and for theoretical accounts of the processes involved. We present evidence and arguments showing: (a) that visual masking techniques, by revealing more detailed aspects of target masking and target recovery, support a theoretical approach to visual masking and visual perception that must take into account activities in two separate neural channels or processing streams and, as a corollary, (b) that at the current stage of methodological sophistication visual masks, by acting in more highly specifiable ways on these pathways, provide information about the microgenesis of form perception not available with TMS masks.     

Sublexical and morphological information in speech processing

Three experiments investigated the impact of syllabic boundary information and of morphological structure on performance in a sequence-monitoring task. In sequence monitoring, participants detect pre-specified sequences of phonemes in spoken carrier words. Sequences corresponded to the first syllable of the carrier word, to its first morpheme, or simultaneously to both. The data from Experiments 1 and 2, using different variants of the monitoring task, showed a strong impact of syllable boundary cues on monitoring latencies. An effect of morphological match between targets and carrier words was also evident. Experiment 3, in which parts of the spoken carrier words were cross-spliced, revealed that syllabic boundary information takes precedence over morphological information. The results are in line with an early process of speech processing, in which syllabic cues are used to aid lexical access. The morphological effect is better understood as a later, probably lexical, contribution of morphological decomposition to monitoring performance.     

Evidence for an Error Monitoring Deficit in Attention Deficit Hyperactivity Disorder

We studied error monitoring in ADHD and control children in a task requiring inhibition of a motor response. The extent of slowing following successful (stopped) and failed (nonstopped) inhibition was compared across groups. We also measured the time required to inhibit a response (stop signal reaction time, SSRT). Compared to controls, ADHD participants slowed less following nonstopped responses. Slowing did not vary with comorbid reading, oppositional, conduct or anxiety disorder, sex or ADHD subtype. Slowing after nonstopped responses was marginally, although significantly correlated with total ADHD symptoms and with age. ADHD participants had significantly longer SSRT than controls, but SSRT was not significantly correlated with slowing. The apparent deficit in error monitoring in ADHD and its independence from the inhibition deficit observed in ADHD has implications for executive control models of ADHD, performance problems associated with the disorder and for component theories of executive control.     

Reality monitoring and metacognitive beliefs related to cognitive confidence in obsessive-compulsive disorder

The present study investigated general reality monitoring ability, and selective reality monitoring ability for anxiety relevant actions in a group of individuals with obsessive-compulsive disorder (OCD) and a group of non-anxious controls. In addition, reality monitoring confidence was assessed, as well as specific meta-cognitive beliefs related to cognitive confidence (by means of the Meta-Cognitions Questionnaire (MCQ)). No differences were found between both groups in actual reality monitoring ability. Unlike previous studies, the reality monitoring task included actions that were related to the individual concerns of the OCD patients and were ideographically selected. Nevertheless, no differential reality monitoring effect was observed for the anxiety relevant stimuli. Data from the MCQ, however, revealed that OCD patients had less overall confidence in their memory for actions and their reality monitoring ability. Analysis of the confidence ratings of the reality monitoring task showed that this reduced confidence was restricted to the neutral actions. No differences were observed for patients that reported low or high frequencies of checking behaviour. The whole of these data do not support memory deficit models of OCD, but are in line with recent emphasis on the importance of memory confidence and other meta-cognitive beliefs in OCD.     

The Timing of Conscious Experience: A Critical Review and Reinterpretation of Libet''s Research

An extended examination of Libet's works led to a comprehensive reinterpretation of his results. According to this reinterpretation, the Minimum Train Duration of electrical brain stimulation should be considered as the time needed to create a brain stimulus efficient for producing conscious sensation and not as a basis for inferring the latency for conscious sensation of peripheral origin. Latency for conscious sensation with brain stimulation may occurafterthe Minimum Train Duration. Backward masking with cortical stimuli suggests a 125–300 ms minimum value for the latency for conscious sensation of threshold skin stimuli. Backward enhancement is not suitable for inferring this latency. For determining temporal relations between stimuli that correspond to subjects' reports, theendof cerebral Minimum Train Duration should be used as reference, rather than its onset. Results of coupling peripheral and cortical stimuli are explained by a latency after the cortical Minimum Train Duration, having roughly the same duration as the latency for supraliminal skin stimuli. Results of coupling peripheral stimuli and stimuli to medial lemniscus (LM) are explained by a shorter LM latency and/or a longer peripheral latency. This interpretation suggests a 230 ms minimum value for the latency for conscious sensation of somatosensory near-threshold stimuli. The backward referral hypothesis, as formulated by Libet, should not be retained. Long readiness potentials preceding spontaneous conscious or nonconscious movements suggest that both kinds of movement are nonconsciously initiated. The validity of Libet's measures of W and M moments (Libet et al., 1983a) is questionable due to problems involving latencies, training, and introspective distinction of W and M. Veto of intended actions may be initially nonconscious but dependent on conscious awareness.     

The quantity and quality of marital interaction related to marital satisfaction: A behavioral analysis

An assessment instrument is presented for the evaluation of the quantity and quality of dyadic interaction, as well as for the daily recording of behaviors presented and omitted which influence marital satisfaction. Comparison of data from ten happy couples and from ten couples entering therapy indicated two distinct dysfunctional patterns among distressed couples, with significantly different patterns of time-together and positive/negative ratios differentiating the happy versus therapy groups. Independent behavioral recording for 14 consecutive days significantly increased husband-wife agreement on a traditional adjustment questionnaire without significantly increasing or decreasing the level of satisfaction being assessed. There was no difference between groups as to interspousal agreement on amount of time together. However, the happy couples agreed on daily quality ratings of the 72 15-minute segments significantly more often than did the distressed couples. Couples at the extremes of the happy-distressed continuum reported rewarding and punishing, respectively, in response to the partners presence, regardless of behaviors emitted. Midrange happy couples defined "pleasant" as positive behaviors presented; midrange distressed couples defined "pleasant" as negative behaviors omitted. Theoretical and clinical implications of behavioral analysis of sequential patterns are discussed.     

The temporal evolution of pre-stimulus slow cortical potentials is associated with an upcoming stimulus’ access to visual consciousness

Slow cortical potentials (SCPs) have been proposed to be essential for the formation of conscious experience. To examine their temporal characteristics, we recorded electroencephalography during a visual backward-masking task, which required participants to localize the missing part of a target stimulus. A subsequent confidence rating was used as a proxy for the target’s access to consciousness. Event-related potentials (ERPs) of all correct trials were determined relative to a brief period immediately before the target and then compared among consciousness levels. In an interval ranging from 2 s prior to target presentation up to this period, a negative relationship between slowly fluctuating ERP values and the level of consciousness became evident. After target presentation, high conscious awareness was characterized by an enhanced visual awareness negativity, an increased P3 component, and associated positive SCPs. Together, these findings add new evidence to the proposed role of SCPs in the emergence of visual consciousness.     

Overstepping the boundaries of free choice: Folk beliefs on free will and determinism in real world contexts

We know little about the commonality of folk beliefs around applications of psychological research on the unconscious control of behaviours. To address this, in Experiment 1 (N = 399) participants volunteered examples of where research on the unconscious has been applied to influence their behaviours. A subset of these were presented in Experiment 2 (N = 198) and Experiment 3 (N = 100). Participants rated the extent to which the behaviour being influenced in these contexts was: (1) via the unconscious, (2) free, (3) the result of prior conscious intentions, (4) under conscious control. Relative to judgements about the extent to which behaviour was influenced via the unconscious, the remaining judgements regarding conscious control of behaviours were either higher (e.g., political contexts) or lower (e.g., therapy). This study is the first to show, using ecologically valid examples, the folk beliefs people share on psychological constructs concerning free will and determinism.     

Loneliness and social monitoring: A conceptual replication of Knowles et al.

Contrary to the claim that loneliness routinely impairs the decoding of social cues such as emotion displays, Knowles, Lucas, Baumeister, and Gardner (2015) proposed that lonely adults “choke under pressure,” experiencing impairments only when social monitoring is framed as diagnostic of general social skill. In four experiments, Knowles et al. showed that lonely individuals performed worse than nonlonely individuals at decoding social cues when the decoding task was framed as a test of social aptitude, but not when it was framed as a test of academic aptitude. The studies were small (N's ranging from 78 to 203), and all employed a convenience sample of mostly female undergraduate students, impairing both statistical power and external validity. In addition, the lack of a true control group precluded the studies from establishing whether loneliness inhibits social monitoring ability if no frame is offered. This study conceptually replicates the central hypothesis of Knowles et al. using a sample of adults that is substantially larger and more diverse demographically and geographically, and using a true control group in addition to the comparison group. Results revealed a significant main effect of loneliness on social monitoring ability but did not replicate the choking under pressure phenomenon.