背外侧前额叶对主动遗忘负性社会反馈的作用：针对抑郁症的TMS研究

抑郁症患者的负性心境可能源于其抑制功能障碍。患者在主动遗忘负性材料时无法有效调用背外侧前额叶(the dorsolateral prefrontal cortex, DLPFC)等负责抑制控制的额叶脑网络。同时, 患者对社会信息的加工比对非社会信息的加工存在更明显的认知神经障碍, 很难主动遗忘对自己不利的社会反馈信息。为了提高抑郁症患者对负性社会反馈的主动遗忘能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在左侧(n = 32)或右侧DLPFC (n = 30)被激活后其记忆控制能力的改变。结果表明, 当患者的DLPFC被TMS激活时, 他们对社会拒绝的回忆正确率与健康对照组(n = 31)无差异, 且TMS激活右侧DLPFC还改善了患者对他人的社会态度。本研究是采用TMS提高抑郁症患者主动遗忘能力的首次尝试, 研究结果不但支持了DLPFC与记忆控制功能的因果关系, 还为临床治疗抑郁症、创伤后应激障碍、药物成瘾等患者的记忆控制缺陷提供了明确的神经靶点。     

Memory and Counterfactual Simulations for Past Wrongdoings Foster Moral Learning and Improvement

In four studies, we investigated the role of remembering, reflecting on, and mutating personal past moral transgressions to learn from those moral mistakes and to form intentions for moral improvement. Participants reported having ruminated on their past wrongdoings, particularly their more severe transgressions, and they reported having frequently thought about morally better ways in which they could have acted instead (i.e., morally upward counterfactuals; Studies 1–3). The more that participants reported having mentally simulated morally better ways in which they could have acted, the stronger their intentions were to improve in the future (Studies 2 and 3). Implementing an experimental manipulation, we then found that making accessible a morally upward counterfactual after committing a moral transgression strengthened reported intentions for moral improvement—relative to resimulating the remembered event and considering morally worse ways in which they could have acted instead (Study 4). We discuss the implications of these results for competing theoretical views on the relationship between memory and morality and for functional theories of counterfactual thinking.     

物体颜色对情景记忆的影响

本研究采用ERP技术和学习-再认范式考察视觉输入的颜色和记忆中的物体颜色知识一致性对情景记忆编码和提取的影响。结果显示, 在对物体图片进行编码时颜色不一致图片诱发更大N400, 而提取阶段则对颜色一致图片有更多熟悉性加工(实验1); 物体名称能够更快激活典型颜色知识, 对颜色一致名称有更多细节回想(LPC更正) (实验2)。实验结果表明, 颜色一致促进知觉水平的记忆编码, 而阻碍语义水平编码。同时, 颜色一致促进物体图片提取(知觉水平)中的熟悉性和回想过程; 而对物体名称提取(概念水平)的促进作用仅表现在回想上。此外, 颜色与物体名称有着密切联系, 同样影响物体的语义表征, 支持激活-扩散模型理论。本研究从知觉和概念水平上为揭示物体颜色在联结记忆中的作用提供了证据。     

Horizontal eye movements foster approach to negative pictures but do not change emotional valence: A dopaminergic regulation hypothesis

A new dopaminergic regulation hypothesis is proposed based on two experiments exploring eye-movement effects. In the Eye Movement Desensitization and Reprocessing (EMDR) and Saccade-Induced Retrieval Enhancement (SIRE) domains, eye-movement mechanisms are mainly studied with explicit measures. Here implicit and explicit measures of emotion and memory for positive and negative pictures were investigated after eye movements or fixation in extreme right-handers. Eye movements enhanced explicit recognition predominantly for negative pictures. The absence of implicit repetition priming in both experiments supported a dissociation between implicit and explicit memory. Motivational eye-movement effects emerged but implicit and explicit affect remained unchanged. Experiment 2 revealed, after initial freezing to negative pictures, an acceleration, particularly of approach responses. Eye movements are postulated to foster approach towards negative memories, and promote, though dopaminergic pathways from the Superior Colliculus, enhanced explicit memory and active emotion regulation, primarily in persons with a collateralization of eye and dopamine dominance.     

面孔线索对4~6岁幼儿真人与卡通面孔记忆的影响

对真人面孔与卡通面孔记忆线索的比较研究,有助于深入认识儿童的面孔认知机制。采用“学习-再认”范式,以内部线索面孔、外部线索面孔和完整面孔为刺激材料,探究面孔线索对4~6岁幼儿真人与卡通面孔记忆的影响。结果发现：（1）女童对真人面孔的记忆显著优于卡通;（2）对卡通面孔的记忆,男童显著优于女童;（3）对真人面孔：完整面孔记忆显著优于内部线索面孔与外部线索面孔;对卡通面孔：外部线索面孔记忆最佳,其次完整面孔,内部线索面孔最低;（4）幼儿对外部与内部线索面孔的记忆能力随年龄逐步提高,6岁显著优于4岁。综上,幼儿对真人面孔与卡通面孔的记忆模式存在差异;且面孔类别、性别、面孔线索与年龄等因素均影响幼儿的面孔记忆。     

激活水平和呈现方式对错误记忆的影响

随机抽取80名大学生参与实验,采用DRM(Deese-Roediger-Mcdermott)范式,探讨了激活水平和呈现方式对错误记忆的影响。结果发现:(1)在随机呈现条件下,关键诱饵的错误再认率显著低于分组呈现条件,但学过项目的正确再认率在两种条件下无差异。(2)在高激活水平条件下,学过项目的正确再认率明显低于低激活水平条件,但关键诱饵的错误再认率在两种激活条件下的差异不够明显。这表明,呈现方式对关键诱饵的错误再认率有显著影响,而激活水平的影响则不显著。由此可知,人们的记忆可以在没有任何外界信息干扰的情况下因内在联想过程而自发地发生改变。     

自然数码奇象记忆法记忆复杂数字的神经机制

本研究采用学习-再认范式和复杂数字记忆材料,考察自然数码奇象记忆法相对于机械记忆法在记忆提取上的优势及神经机制。行为结果表明,自然数码奇象记忆法比机械记忆法的再认准确率更高。事件相关电位分析结果显示,再认提取阶段奇象记忆条件下诱发的N400和N700波幅显著更低,这说明奇象记忆提取更容易。在自然数码奇象记忆条件下,正确再认旧数字诱发的前额区、左顶枕叶区及中顶枕叶区N700成分与使用自然数码奇象记忆有关。本研究表明,采用自然数码奇象记忆可以减少或跨越语义加工,从而提高个体对材料的记忆效率。     

Looking at remembering: Eye movements,pupil size,and autobiographical memory

To examine the relationship between visual imagery and autobiographical memory, eye position and pupil size were recorded while participants first searched for memories and then reconstructed the retrieved memories (Experiment 1), or only searched for memories (Experiment 2). In Experiment 1, we observed that, although recollective experience was not associated with the number of fixations per minute, memories that took longer to retrieve were linked to increased pupil size. In Experiment 2, we observed that directly retrieved memories were recalled more quickly and were accompanied by smaller pupils than generatively retrieved memories. After correcting for response time, retrieval mode also produced an effect, showing that decreased pupil size is not simply due to directly retrieved memories being recalled more quickly. These findings provide compelling evidence that objective measures, such as pupil size, can be used alongside subjective measures, such as self-reports, to distinguish between directly retrieved and generatively retrieved memories.     

Elucidating the mental processes underlying the direct retrieval of autobiographical memories

The literature on autobiographical memory retrieval has directed much attention to the concepts of direct retrieval (fast, automatic retrieval) and generative retrieval (slower, deliberative/strategic retrieval). Among the many findings reported on these phenomena, their relative prevalence has stood out as a central feature in many studies, with most studies reporting the frequency of direct retrieval as equal to or exceeding generative retrieval. In this study, we used the retrieve-aloud procedure (a method where participants verbalize their thoughts while retrieving) to delve more deeply into the nature of reports of ubiquitous direct retrieval. We hypothesized that much of the direct retrieval reported in literature is not bona fide direct retrieval (i.e., seemingly automatic retrieval), but is a combination of other retrieval processes, including generative-like retrieval processes. Our results supported this view, showing that less than one-half of all of the observed direct retrievals were bona fide direct retrieval, while the rest were a form of generative retrieval, or fell somewhere in between direct and generative retrieval. We argue that the results suggest that the prevalence of direct retrieval may be overestimated in the literature, and we further propose an alternative classification schema for direct retrievals.     

States of curiosity and interest enhance memory differently in adolescents and in children

Curiosity – broadly defined as the desire to acquire new information – enhances learning and memory in adults. In addition, interest in the information (i.e., when the information is processed) can also facilitate later memory. To date, it is not known how states of pre‐information curiosity and post‐information interest enhance memory in childhood and adolescence. We used a trivia paradigm in which children and adolescents (N = 60, 10–14 years) encoded trivia questions and answers associated with high or low curiosity. States of high pre‐answer curiosity enhanced later memory for trivia answers in both children and adolescents. However, higher positive post‐answer interest enhanced memory for trivia answers beyond the effects of curiosity more strongly in adolescents than in children. These results suggest that curiosity and interest have positive effects on learning and memory in childhood and adolescence, but might need to be harnessed in differential ways across child development to optimize learning.