干细胞移植治疗冠心病的现状与未来

冠心病仍然是全球的主要死亡原因。其所造成的心肌梗死及慢性心力衰竭对生活质量的影响和由此造成的高额医疗费用促使我们不断寻求新的医疗措施。近几年有关干细胞用于心肌梗死后心肌再生、心肌内新生血管形成,可能还会改善梗死后的心功能的研究成为心脏病学研究的最热门领域。尽管干细胞治疗有可能使心力衰竭的治疗得到彻底的革命,但仍有部分问题需要澄清。已发表的各个研究结果设计不尽相同,致使对该项治疗的效果较难得出一致的结论。但这些研究都强调干细胞治疗在未来心血管疾病的治疗中可能会发挥较大的作用。干细胞治疗与药学、外科及介入治疗的结合会显著改善冠心病患者的预后。     

风湿性心脏病瓣膜置换术后抗凝治疗中“度”的把握

风湿性心脏瓣膜病在世界范围内发病率极高,瓣膜置换术是目前治疗该病的主要方法,根据不同的病情及需要可置换机械瓣或生物瓣,我国患者更常选择机械瓣置换,术后生物瓣置换需抗凝3个月～6个月,而机械辩置换者需终身抗凝,故抗凝治疗非常关键。本文从辨证思维的角度分析如何在瓣膜置换术后把握好抗凝治疗。     

奖惩线索对停止信号任务中抑制能力和心率、皮肤电的影响

采用不同类型强化刺激(中性刺激,奖励刺激,惩罚刺激,以及奖励、惩罚刺激并存)来改变可获得奖励和惩罚的强度和频度,分别考察不同类型强化条件对停止信号任务中抑制能力、心率和皮肤电的影响.结果显示:与奖惩混合条件相比,在奖励条件下,被试的反应速度快,但正确抑制率明显低于惩罚条件和奖惩混合条件;在奖励条件下,被试在任务完成过程中的心率明显高于反馈条件、惩罚条件和奖惩混合条件.四种条件下被试的皮肤电活动无差异.     

《管子》的养生智慧

在古代中国,作为一种人格理想典型的“圣人”具有导向作用,《管子》塑造圣人品格,当然也是为了给人们确立人生目标。故而,学习圣人也就包括学习养生在内。在《管子·白心》篇中有一个养生的重要命题,叫做“执仪服象,敬迎来者”,这不仅是就如何“成圣”说的,而且对于一般人的生活而言也具有养生的借鉴价值。根据圣人理想人格的修养标准,《管子》不仅将治国与养生结合起来,而且具体探究如何“理气”的问题。     

Signal detection theory,the exclusion failure paradigm and weak consciousness—Evidence for the access/phenomenal distinction?

Block [Block, N. (2005). Two neural correlates of consciousness. Trends in Cognitive Science, 9, 46–52] and Snodgrass (2006) claim that a signal detection theory (SDT) analysis of qualitative difference paradigms, in particular the exclusion failure paradigm, reveals cases of phenomenal consciousness without access consciousness. This claim is unwarranted on several grounds. First, partial cognitive access rather than a total lack of cognitive access can account for exclusion failure results. Second, Snodgrass’s Objective Threshold/Strategic (OT/S) model of perception relies on a problematic ‘enable’ approach to perception that denies the possibility of intentional control of unconscious perception and any effect of following different task instructions on the presence/absence of phenomenal consciousness. Many of Block’s purported examples of phenomenal consciousness without cognitive access also rely on this problematic approach. Third, qualitative difference paradigms may index only a subset of access consciousness. Thus, qualitative difference paradigms like exclusion failure cannot be used to isolate phenomenal consciousness, any attempt to do so still faces serious methodological problems.     

Attributions for social failure and adolescent aggression

In the present study, 119 high school boys and 79 institutionalized delinquent boys of the same age range were assessed on their own aggressive behavior and on their tendencies to attribute social failure to controllable, external, stable causes, anticipate a hostile affective response, and endorse aggressive behavioral responses to by pothetical social situations. While the two populations of boys did not differ detectably in their attributional tendencies, the relations between an individual's aggressiveness and an individual's attributions differed considerably across the two populations. In particular, among deliquent but not among delinquent but not among nondelinquent boys, the tendency to attribute one's social failures to stable and controllable causes predicted stronger hostile emotional responses to failure and a tendency to endorse physically aggressive responses following such failure. These hostile emotional responses to failure and this preference for a physically aggressive response, in turn, predicted greater actual aggression within the population of delinquent boys. Neither of these links could be demonstrated for nondelinquent boys. However, in the nondelinquent sample, attributing social failure to external and controllable causes predicted endorsement of aggressive responses only indirectly through increased hostile affect. It was concluded that the specific relations between cognitive and affective responses to social failure may be a contributing factor to the serious physical aggression displayed by some delinquents and to the less serious aggression of nondelinquents. © 1993 Wiley-Liss, Inc.     

爆发怒与潜在怒及其在认知操作中的功能

研究旨在证明;实验1.实验室人工诱发婴儿被试愤怒情绪被划分为爆发怒与潜在怒两种愤怒表现形式,它们在婴儿进行的“迂回”作业操作中显示了不同的功能作用：爆发怒被试的操作效果显著优于潜在怒被试。实验２．以实验１同样的方法诱发婴儿被试愤怒情况下,在另一项“寻找”作业中验证了爆发怒与潜在怒两种愤怒形式确实具有不同的功能作用,实验２以心率水平测量作为验证指标。     

非稳态噪声对动物行为及心脏自由基损伤的影响

本研究用采集的多用木工机床和冲击电钻发出的噪声对 5天、1 0天和 2 0天三个噪声干扰组的动物进行干扰 ,以研究非稳态噪声对动物行为及心脏组织自由基损伤的影响。结果发现 ,非稳态噪声可引起动物旷场反应中走格数减少 ,站立及洗脸次数增加 ,并可诱发心脏组织的自由基反应 ,导致心脏组织的损害。因此得出结论 :①非稳态噪声可以对动物行为产生影响 ,并随着噪声暴露时间的延长而增强 ;②非稳态噪声可以造成心脏组织的自由基损伤。这一现象提示自由基损伤是介导噪声对心脏功能影响的重要因素之一。     

心与脑称谓互换的科学意义

由于历史渊源的原因,心、心理、心情、心身医学所指的功能意义是心脏的功能,在我国已经有几千年的历史,古希腊历史上也类同,也存在心和脑概念的混淆和歧义,这对脑科学概念的使用产生了严重影响,对脑科学概念的形成起到了消极作用。随着脑科学和语言学的发展,心所指的实际上是脑器官及脑的功能意义,所以心与脑称谓互换更能清晰地、确切地、准确地、科学地表达脑及脑的功能意义,只有语言和事物本质属性正确联系在一起,才能使科学进步和发展。