The association between cognitive ability across the lifespan and health literacy in old age: The Lothian Birth Cohort 1936

Three hundred and four participants in the Lothian Birth Cohort 1936 study took a validated IQ-type test at age 11 years and a battery of cognitive tests at age 70 years. Three tests of health literacy were completed at age 72 years; the Rapid Estimate of Adult Literacy in Medicine (REALM), the Test of Functional Health Literacy in Adults (S-TOFHLA), and the Newest Vital Sign (NVS). Participants who had a lower childhood IQ exhibited poorer performance on all three tests of health literacy taken in older adulthood. Relative cognitive change from age 11 to 70 and education were also important factors influencing performance on health literacy tasks, independent of childhood cognitive ability. It is important to understand the determinants of low health literacy in order to support individuals in managing their own health.     

Dispositional mindfulness moderates the relation between neuroticism and depressive symptoms

Negative emotional reactivity as measured by neuroticism has been shown to be an important risk factor for the development of depressive symptoms. This study investigated whether the ability to be mindful can protect against the negative effects of this temperamental vulnerability. An English community sample of N = 144 individuals who had completed a neuroticism questionnaire six years previously were assessed for current depressive symptoms and dispositional levels of mindfulness at points of assessment approximately one year apart. Dispositional mindfulness moderated the relation between neuroticism and current depressive symptoms: Neuroticism was significantly related to depression in those with low to medium levels of dispositional mindfulness but not in those with relatively high levels of mindfulness. Further analyzes focusing on particular mindfulness skills indicated that this effect was carried mostly by the ability to describe inner experience. The results suggest that dispositional mindfulness and particularly the ability to describe inner experience are helpful in dealing with negative emotional reactivity in a way that reduces the likelihood of depressive symptoms to develop.     

Cognitive impairment and whole brain diffusion in patients with neuromyelitis optica after acute relapse

The objective of this study investigated cognitive impairments and their correlations with fractional anisotropy (FA) and mean diffusivity (MD) in patients with neuromyelitis optica (NMO) without visible lesions on conventional brain MRI during acute relapse. Twenty one patients with NMO and 21 normal control subjects received several cognitive tests to assess cognitive function. Head diffusion tensor imaging (DTI) of all patients with NMO were collected with a 3-T MR system. Correlations of cognitive test scores and whole brain FA and MD were examined by voxel-based analysis. Region-of-interest analysis was applied to the significantly correlated regions which the most frequently appeared. We found that NMO patients without visible brain lesions had significantly impaired learning and memory, decreased information processing speed, and damaged attention compared with normal control subjects. These impaired cognitive domains were significantly correlated with FA and MD in local regions of corpus callosum, anterior cingulate and medial frontal cortex. In corpus callosum of NMO patients, mean FA was significantly lower and mean MD higher than normal control subjects. Our findings suggest that cognitive impairments in learning and memory, information processing speed and attention occur in NMO patients without visible brain lesions during acute relapse. The impairments in immediate and short-term memory in NMO patients may be due to information encoding deficits in the process of information acquisition. The corpus callosum of such patients may have local microscopic damages that play a role in cognitive impairments during acute relapse.     

Impact of motivation on cognitive control in the context of vigilance lowering: an ERP study

We assessed the effects of time-on-task on cognitive control expressed by the CRN/Nc and the extent to which motivation modulates this relationship. We utilized two groups of participants, who were told that their performance would (evaluation condition) or would not (control condition) be evaluated online. Both groups performed a version of the Eriksen Flanker Task for 60 min. We observed classical vigilance lowering, manifested by a progressive performance decline with time-on-task, in the control, but not in the evaluation, condition. In the latter, performance remained stable throughout the task. ERP analysis indicated the same interaction in our main component of interest, the CRN/Nc, whose amplitude decreased from the first to the last period in the control condition but remained stable over time in the evaluation condition. To our knowledge, this study is the first to demonstrate the impact of motivation on monitoring processes as indexed by the correct response negativity, in the context of a prolonged task. Vigilance lowering caused by a repetitive and prolonged flanker task, results in compromised response control and compromised control of correct responses. Our results suggest that alterations in ACC functioning may underlie vigilance decline and can be viewed as evidence that the action monitoring functions of the ACC can be positively affected by motivation.     

Assessing miserly information processing: An expansion of the Cognitive Reflection Test

The Cognitive Reflection Test (CRT; Frederick, 2005) is designed to measure the tendency to override a prepotent response alternative that is incorrect and to engage in further reflection that leads to the correct response. It is a prime measure of the miserly information processing posited by most dual process theories. The original three-item test may be becoming known to potential participants, however. We examined a four-item version that could serve as a substitute for the original. Our data show that it displays a .58 correlation with the original version and that it has very similar relationships with cognitive ability, various thinking dispositions, and with several other rational thinking tasks. Combining the two versions into a seven-item test resulted in a measure of miserly processing with substantial reliability (.72). The seven-item version was a strong independent predictor of performance on rational thinking tasks after the variance accounted for by cognitive ability and thinking dispositions had been partialled out.     

Behavioural adaptation and effectiveness of a Forward Collision Warning System depending on a secondary cognitive task

Forward Collision Warning Systems (FCWS) have been designed to enhance road safety by reducing the number of rear-end collisions. Nevertheless, little is known about how drivers adapt their behaviour over time when using this kind of system. In addition, these systems are expected to aid particularly distracted drivers. However, previous research has suggested that the effectiveness of the system could depend on the difficulty level of the secondary task. The objective of this study on driving simulator was twofold. Firstly, it consisted in evaluating the behavioural adaptation to an FCWS as well as analysing the possible consequences of driving without the system after a short period of adaptation. Secondly, it was to evaluate the effectiveness of the system according to two different difficulty levels of a cognitive secondary task. The results showed that drivers adapted their behaviour positively when the system was introduced. Nevertheless, both the effectiveness and the behavioural adaptation in the short term were dependent on the cognitive load induced by the secondary task. These findings suggest that the warning needs some attentional resources to be processed. Finally, no negative or transfer effect was observed following the removal of the system after a short period of adaptation.     

Global coherence in younger and older adults: Influence of cognitive processes and discourse type

The purpose of the present research was to examine the influence of cognitive processes on discourse global coherence ability measured across different discourse tasks and collected from younger (n = 40; 20–39 years) and older (n = 40; 70–87 years) cognitively healthy adults. Study participants produced oral language samples in response to five commonly used discourse elicitation tasks and they were analyzed for maintenance of global coherence. Participants also completed memory and attention measures. Group differences on the global coherence scale were found for only one type of discourse—recounts. Across discourse elicitation tasks the lowest global coherence scores were found for recounts compared to the other discourse elicitation tasks. The influence of cognitive processes on maintenance of global coherence differed for the two age groups. For the younger group, there were no observed significant relationships. For the older group, cognitive measures were related to global coherence of stories and procedures.     

Age-related differences in working memory: ERPs reveal age-related delays in selection- and inhibition-related processes

Faulty inhibition is implicated in age-related working memory decline. ERP signs of selection and inhibition of items in working memory (WM) are, respectively, a cue-locked parietal positivity (～350 ms) and a probe-locked frontal negativity (～520 ms). To determine when in the older age range differences in selective and inhibitory processes might occur, ERPs were recorded in a WM task from 20 young (20–28), 20 young–old (60–70), and 20 old–old (71–82) adults. A 4-digit display was followed by a cue indicating which 2 of 4 digits were relevant. Proactive interference (PI), the reaction time difference between a matching and non-matching to-be-ignored digit was larger, relative to the young, in both older groups. Compared to the young, both the cue- and probe-locked activities were prolonged in the older groups. Although there were no topographic differences among the age groups, the prolonged PI and associated ERPs suggest a relative age-related deficit in inhibition.     

Executive process training in young and old adults

There is a growing body of research on the modifiability of executive functions in different stages of life. Previous studies demonstrate robust training effects but limited transfer in younger and particularly in older adults. The aim of the present study was to investigate whether a theoretically derived intervention for executive functioning, addressing several basic processes (updating, shifting, and inhibition), can induce transfer effects in early and late adulthood. Fifty-nine healthy adults, 29 young and 30 older adults, were randomly assigned to either training or no-contact control groups. The training groups received 15 sessions of executive process training for about 45 min/session during 5 weeks. A test battery including a criterion task and near, intermediate, and far transfer tasks was administered before and after training. Results showed pronounced age-equivalent gains on the criterion task. Near transfer was seen to non-trained updating and inhibition tasks for the young and older trained participants. However, only the young adults showed intermediate transfer to two complex working memory tasks. No far transfer effects were seen for either age group. These findings provide additional evidence for age-related constraints in the ability to generalize acquired executive skills, and specifically show that training of multiple executive processes is not sufficient to foster transfer beyond the very near in older adults.