Neurobehavioral Characteristics of Children with Duchenne Muscular Dystrophy

This study investigated cognitive, metacognitive, and psychosocial aspects of neurobehavioral functioning in 22 boys with Duchenne muscular dystrophy (DMD) and 18 unaffected siblings, all between the ages of 6 and 16 years. Probands and siblings completed the Wechsler Abbreviated Scale of Intelligence, as well as selected subtests from the Children's Memory Scale and from the Delis-Kaplan Executive Function System, while parents completed the Child Behavior Checklist and the Behavior Rating Inventory of Executive Function. Compared to siblings, probands demonstrated relative weaknesses on both verbal and nonverbal measures of delayed recall and response generation and were rated by parents as having more difficulties with social interaction, initiation, and adaptation. It is concluded that DMD is associated with mild but potentially significant difficulties in a range of neurobehavioral areas, likely related to deficient dystrophin levels in an integrated brain circuit that includes the cerebellum, hippocampus, and association neocortex.     

Executive functions in extremely low birth weight and late-preterm preschoolers: Effects on working memory and response inhibition

Executive function (EF) refers to fundamental capacities that underlie more complex cognition and have ecological relevance across the individual's lifespan. However, emerging executive functions have rarely been studied in young preterm children (age 3) whose critical final stages of fetal development are interrupted by their early birth. We administered four novel touch-screen computerized measures of working memory and inhibition to 369 participants born between 2004 and 2006 (52 Extremely Low Birth Weight [ELBW]; 196 late preterm; 121 term-born). ELBW performed worse than term-born on simple and complex working memory and inhibition tasks and had the highest percentage of incomplete performance on a continuous performance test. The latter finding indicates developmental immaturity and the ELBW group's most at-risk preterm status. Additionally, late-preterm participants performed worse compared with term-born on measures of complex working memory but did not differ from those term-born on response inhibition measures. These results are consistent with a recent literature that identifies often subtle but detectable neurocognitive deficits in late-preterm children. Our results support the development and standardization of computerized touch-screen measures to assess EF subcomponent abilities during the formative preschool period. Such measures may be useful to monitor the developmental trajectory of critical executive function abilities in preterm children, and their use is necessary for timely recognition of deficit and application of appropriate interventional strategies.     

Prenatal SSRI exposure: Effects on later child development

The aim of this review is to integrate research on the pharmacological mechanisms of selective serotonin reuptake inhibitors (SSRIs) and the following effects on fetal brain development and child cognitive function seen in children with prenatal exposure to SSRIs. As antidepressants are transferred from the mother to the fetus through the placenta, the fetus is vulnerable to alterations in neurotransmission and possibly altered neural functioning. Because of this risk, pregnant women suffering from depression are often advised to discontinue their use of antidepressants during pregnancy. Though, maternal untreated depression may also have negative consequences for the fetus and child after birth. In the present review, we find a distinction between studies of early versus late development. Studies on early cognitive development indicate no negative effects, while studies on later development report some cognitive difficulties and behavioral problems, indicating latent effects of exposure. However, the reviewed studies are not all converging, and it is not clear whether and to what extent prenatal SSRI exposure affects cognitive development.     

Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States

Background: The most common route for general population exposure to methyl mercury (MeHg) is fish consumption. Recommendations to pregnant women about consuming fish contaminated with MeHg are also applied to children, but there are few studies available about the effects of low-level postnatal MeHg exposure in them.

Objectives: To investigate the association between postnatal methyl mercury exposure and neuropsychological development in a study of children also exposed to lead, both measured at 7 years.

Methods: We measured MeHg concentrations in blood samples from the Treatment of Lead-Exposed Children (TLC) trial in which 780 children with elevated concentrations of lead in blood were followed with neuropsychological tests from ages 12–33 months through 7 years. Here we examine blood MeHg concentration and neuropsychological test scores, both measured at age 7 years. We used a maximum likelihood method to estimate geometric mean MeHg concentration and generalized linear regression models to analyze MeHg and neuropsychological test scores.

Results: Geometric mean MeHg concentration was 0.56 (95% confidence interval: 0.52, 0.59) μg/L. A 1 μg/L increase in MeHg was associated with a 2.1 (95% confidence interval: 0.4, 3.8) point increase in Full-Scale IQ and 0.2 (95% confidence interval: 0.02, 0.4) point increase in Learning Slopeindex T-score on a test of verbal memory.

Conclusions: Our results suggest that the relatively low MeHg exposure in US school-aged children from this population has no detectable adverse effect on neuropsychological development. The positive associations observed between MeHg and neurodevelopment may indirectly reflect consumption of beneficial polyunsaturated fatty acids from seafood.     

The Contribution of Professor Ninian Smart to Religious Education

Religious Experience Reconsidered was premised on the idea that experience is a site of contested meaning and value for subjects (and scholars). Although the concept of specialness has drawn considerable attention, my goal in writing the book was to update efforts to use attribution theory to bridge between religious studies and the psychology of religion. I intended the focus on micro-social processes to complement analysis at the macro-social level. The need for a broader, more generic second order term, such as specialness, emerged in the context of working out an attributional approach and can and should be extended more broadly. While anything can be set apart as special and an analysis of the politics of deeming is essential, we can still ask if there is empirical evidence to suggest that humans are more likely to set some things apart than others within or across cultures. When we take experience as a site for study, we do not have to limit ourselves to describing the range of views held by our subjects, but can also legitimately seek to explain experience in terms that make sense to us as researchers. The breaking of taboos against explaining experience in naturalistic terms will only have apocalyptic consequences if we assume a special/ordinary binary; viewed on a continuum, we can still find special meaning and value in experiences that are not protected by taboos.     

The relative unnaturalness of atheism: On why Geertz and Markússon are both right and wrong

Commonly scholars in the cognitive science of religion (CSR) have advanced the naturalness of religion thesis. That is, ordinary cognitive resources operating in ordinary human environments typically lead to some kind of belief in supernatural agency and perhaps other religious ideas. Special cultural scaffolding is unnecessary. Supernaturalism falls near a natural anchor point. In contrast, widespread conscious rejection of the supernatural as in atheism appears to require either special cultural conditions that upset ordinary function, cognitive effort, or a good degree of cultural scaffolding to move people away from their maturationally natural anchor-points. Geertz and Markússon (2009) identify ways to strengthen cognitive approaches to the study of religion and culture, including atheism, but fail to demonstrate that atheism is as natural in a comparable respect as theism.     

Explicit and implicit Need for Cognition and bottom-up/top-down attention allocation

Need for Cognition (NFC), the tendency to engage in and enjoy thinking, is usually directly measured via self-report. In order to validate an indirect NFC Implicit Association Test, we followed up on evidence suggesting NFC to be related to electrocortical indicators of bottom-up and top-down attention allocation in an oddball paradigm. In 99 participants, we did not find effects of directly and indirectly measured NFC on the processing of task-irrelevant stimuli, but found a main effect of explicit NFC on bottom-up target processing and an interactive effect of explicit and implicit NFC on top-down target processing. These findings further implicate NFC in the modulation of attention allocation and highlight the usefulness of direct and indirect measures in individual differences research.     

Power and spatial relations

Embodied views of language hold that perceptual and motor simulations are involved during comprehension. Study 1 investigated power-related language in a picture recognition task wherein participants judged whether the picture presented at either the upper or lower screen position matched the sentence. In Study 2, participants chose the picture that best described the sentence between two (identical) images that were aligned vertically. Results demonstrated that participants responded faster to pictures presented at the implied location and chose that picture more often. Such results suggest that spatial information implicit in power-related language is involved in linguistic comprehension.     

The effect of mortality salience on the attitudes toward state control: The case of Russia

Our study examined the effects of mortality salience (MS) on attitudes toward state control in different domains in Russia. Using the theory of Conservatism as Motivated Social Cognition (CMSC) and the Terror Management Theory (TMT), we put forward two alternative hypotheses. Based on the CMSC, MS would enhance the approval of state control in different spheres, while, in line with TMT, the MS effect would be dependent on pre-existing views. The participants in the study were 450 Russian students who completed a questionnaire to measure attitudes toward state control in six spheres of life (the economy, the mass media, political parties, social organisations, science and education). After a week, they were randomly assigned one of three conditions—MS, frightening, and a neutral condition—and again completed the questionnaire on political attitudes. Our results showed that MS mostly provokes “control shifting,” confirming the CMSC's hypothesis. However, a separate analysis conducted among people with different pre-existing political attitudes has revealed that “control shifting” is more pronounced for freedom-oriented participants. We discuss these findings in line with alternative views on the nature of the MS effect and specifics of socio-political context.