遗传与环境在食管癌发生发展中的作用

食管癌是我国最常见的恶性肿瘤之一,有明显的地域分布特征,提示环境起着主要作用。但近年来有大量研究表明遗传因素在食管癌的发生中起着不可忽视的作用。食管癌是多种因素作用,多基因参与的疾病,是环境与遗传共同作用的结果。     

Progress in the Molecular-Genetic Study of Intelligence

ABSTRACT— The past decade has seen a major shift in the genetic study of human intelligence; where classic studies aimed to quantify the heritability of intelligence, current studies aim to dissect this heritability into its molecular-genetic components. Five whole-genome linkage scans have been published in the past year, converging on several chromosomal (or genomic) regions important to intelligence. A handful of candidate genes, some of which lie in these genomic regions, have shown significant association to intelligence and the associations have been replicated in independent samples. Finding genes brings us closer to an understanding of the neurophysiological basis of human cognition. Furthermore, when genes are no longer latent factors in our models but can actually be measured, it becomes feasible to identify those environmental factors that interact and correlate with genetic makeup. This will supplant the long nature–nurture debate with actual understanding.     

学校归属感与学生发展的探索研究

采用问卷调查法探讨中小学生的学校归属感与学校适应、自我概念、同伴关系及班级环境的关系。结果表明:1)学校适应、自我概念、同伴关系和班级环境与中小学生的学校归属感有密切的关系;2)学校归属感能有效的预测学生的自我概念;3)师生关系和同伴关系对学校归属感有重要影响,是学校归属感显著的预测变量;4)学校类型对学校归属感有显著的影响,重点中学学生的学校归属感显著高于其他类型学校的学生。     

青少年学生的人际信任度与家庭因素的相关研究

该文对青少年学生的人际信任度与家庭因素的关系进行研究,结果表明:1)青少年学生人际信任度的性别差异不显著;2)青少年学生人际信任度的年级差异显著:大学生的人际信任水平最低,初中生的最高,职业中专学生的与大学生的相近;3)青少年学生的人际信任度与其家庭环境的相关不显著。     

A longitudinal and multi-method examination of interest–occupation congruence within and across time

Remarkably little research has addressed change and stability in person–environment fit across time. The objective of the current study was to address this gap in the literature by investigating Holland interest–occupation congruence across time for a sample of college alumni (N = 167) that were tracked during the first third of their professional career. Congruence was examined in all its complexity, including a repeated assessment of both occupations and interests, the use of objective (O*NET) and subjective (self-report) environment assessment methods, and adopting sophisticated congruence calculation methods (i.e., Euclidean distance and profile correlation). This resulted in a total of 12 interest–occupation comparisons within and across time that could be related to general and career specific well-being. The results first indicated moderate levels of stability in interests and occupations across the 15-year time interval, yet also with room for change. Congruence analyses indicated significant interest–occupation fit at the beginning of the career and 15 years later, with the magnitude of congruence slightly varying depending on which occupation assessment and which congruence method was used. Profile correlation congruence did not change over time in absolute terms and evidenced relative stability. Euclidean distance indices had little relative stability over time but did manifest some absolute changes in levels of congruence. Finally, job change moderated the association between interest–occupation congruence and life satisfaction in such a way that higher levels of satisfaction were reported only when little job change was present.     

Quality child care supports the achievement of low-income children: Direct and indirect pathways through caregiving and the home environment

Existing studies of child care have not been able to determine whether higher quality child care protects children from the effects of poverty, whether poverty and lower quality child care operate as dual risk factors, or whether both are true. The objective of the current study was to test two pathways through which child care may serve as a naturally occurring intervention for low-income children: a direct pathway through child care quality to child outcomes, and an indirect pathway through improvements in the home environment. Children were observed in their homes and child care settings at 6, 15, 24, and 36 months. An interaction between family income-to-needs ratio and child care quality predicted School Readiness, Receptive Language, and Expressive Language, as well as improvements in the home environment. Children from low-income families profited from observed learning supports in the form of sensitive care and stimulation of cognitive development, and their parents profited from unobserved informal and formal parent supports. Policy implications are discussed.     

How Do You Say Nature?: Opening the Design Space with a Knowledge Environment

In this paper, we describe a design study on how families in Los Angeles experience nature, with a particular focus on how using alternative formats for research analysis and presentation can enrich a design research inquiry. Conducted in Pasadena, CA as a part of Super Studio, the year-long design research class emphasized knowledge building and sharing through design methods of analysis, exhibition, and concept prototypes. After conducting interviews and engaging participants with probes, the class built the results into an open-ended knowledge environment. The main observation from the exhibition – that Angelenos have a limited vocabulary for describing nature and their interaction with it – helped to define the opportunity for design intervention that created connection points between Angelenos and nature. There are few attempts to describe how probe returns evolve into design concepts. Showcased is a process that depends on the unique affordances of design as the vehicle for discovery and invention.     

Environments That Make Us Smart: Ecological Rationality

ABSTRACT— Traditional views of rationality posit general-purpose decision mechanisms based on logic or optimization. The study of ecological rationality focuses on uncovering the "adaptive toolbox" of domain-specific simple heuristics that real, computationally bounded minds employ, and explaining how these heuristics produce accurate decisions by exploiting the structures of information in the environments in which they are applied. Knowing when and how people use particular heuristics can facilitate the shaping of environments to engender better decisions.     

Modified Dialectical Behavior Therapy and Problem Solving for Obsessive-Compulsive Personality Disorder

The impact of a modified dialectical behavior therapy and problem-solving model is examined on the work environment of a patient with an obsessive-compulsive personality disorder (OCPD). A case study is presented examining the impact this client's OCPD behavior in the work environment and on his subordinates. Discussed are interventions that were useful in treating a motivated patient employing cognitive-behavioral models of treatment for this disorder. The case study focuses on the work setting and the issues tied to the work environment wherein subordinates are required to work under a supervisor with OCPD. Lessons learned, issues and import for further study are offered.