遗传与环境在食管癌发生发展中的作用

食管癌是我国最常见的恶性肿瘤之一,有明显的地域分布特征,提示环境起着主要作用。但近年来有大量研究表明遗传因素在食管癌的发生中起着不可忽视的作用。食管癌是多种因素作用,多基因参与的疾病,是环境与遗传共同作用的结果。     

Quality child care supports the achievement of low-income children: Direct and indirect pathways through caregiving and the home environment

Existing studies of child care have not been able to determine whether higher quality child care protects children from the effects of poverty, whether poverty and lower quality child care operate as dual risk factors, or whether both are true. The objective of the current study was to test two pathways through which child care may serve as a naturally occurring intervention for low-income children: a direct pathway through child care quality to child outcomes, and an indirect pathway through improvements in the home environment. Children were observed in their homes and child care settings at 6, 15, 24, and 36 months. An interaction between family income-to-needs ratio and child care quality predicted School Readiness, Receptive Language, and Expressive Language, as well as improvements in the home environment. Children from low-income families profited from observed learning supports in the form of sensitive care and stimulation of cognitive development, and their parents profited from unobserved informal and formal parent supports. Policy implications are discussed.     

Modified Dialectical Behavior Therapy and Problem Solving for Obsessive-Compulsive Personality Disorder

The impact of a modified dialectical behavior therapy and problem-solving model is examined on the work environment of a patient with an obsessive-compulsive personality disorder (OCPD). A case study is presented examining the impact this client's OCPD behavior in the work environment and on his subordinates. Discussed are interventions that were useful in treating a motivated patient employing cognitive-behavioral models of treatment for this disorder. The case study focuses on the work setting and the issues tied to the work environment wherein subordinates are required to work under a supervisor with OCPD. Lessons learned, issues and import for further study are offered.     

医学教育环境测量评价的实践与探索

重点讨论了医学教育环境测量和评价在医学教育改革中的地位和作用,在借鉴国外先进经验的基础上,在教育环境评价和教师评价方面提出了重视学生感受,重视教育环境的动态评价,科学公正地评价教师,建立全面系统的分析方法,建立评价的分析反馈机制等看法.     

Environmental enrichment improves behavioral performance and auditory spatial representation of primary auditory cortical neurons in rat

Environmental enrichment (EE) has an important role in brain plasticity. Early research has shown that EE increases the response strength of neurons in the auditory cortex, but it remains unknown whether EE can influence the process of spatial localization in the auditory system. In this study, we raised rats in enriched and standard conditions from postnatal day 10 to day 56. By testing behavioral tasks via auditory cues, we have shown that EE improved the number of correct scores, but decreased the reaction time and azimuth deviation in behavioral performance of sound-azimuth discrimination. By in vivo extracellular recording, we have shown that EE enhanced the directional sensitivity of neurons in the primary auditory cortex. For example, EE rats had a smaller spatial receptive field, sharper frequency tuning curve and directional selective curve of auditory neurons compared with normal rats. Our findings indicate that early exposure to EE increases directional sensitivity. These results provide an insight into developmental plasticity in the auditory system.     

Environmental Contributions to Adolescent Delinquency: A Fresh Look at the Shared Environment

Few genetically-informative studies have attempted to explicitly identify the shared environmental (i.e., those environmental influences that contribute to sibling similarity) factors now known to contribute to adolescent delinquency. The current study therefore examined whether the parent-child relationship served as one source of these shared environmental influences. Participants were 610 adoptive and biological families from the Sibling Interaction and Behavior Study (SIBS). Parents and adolescents reported on their parent-child conflict and parental involvement with child, and adolescents reported on their own delinquent behaviors. We employed structural equation modeling and supplementary multilevel modeling, finding consistent evidence that the association between delinquency and the parent-child relationship is at least partially shared environmental in origin. Such findings provide an important extension of previous twin studies, as they suggest that passive genotype-environment correlations do not explain earlier findings of shared environmental influences on this association.     

大学生学习体验与学习结果的关系：学生投入的中介作用

选取3063名大学二年级本科生（平均年龄19.76 ± 0.73岁）为被试,考察大学生投入在学习体验（课堂学习体验和课外学习体验）和学习结果（学业成就、共通能力和学习满意度）间的中介作用。结果发现：（1）大学生投入在学习体验和学业成就间起部分中介作用;（2）大学生投入在学习体验和共通能力间起完全中介作用;（3）大学生投入在学习体验和满意度间起部分中介作用。     

非正式学习环境中幼儿的自发数量聚焦

大量从“能力”角度来探讨个体早期数学发展的研究仅专注于儿童早期的数学知识和技能, 而忽略了可能与儿童早期数学能力相关的方面。近年来, 数学认知发展研究者逐渐开始关注自发数量聚焦(Spontaneous focusing on numerosity, SFON), 即个体对环境中数量相关信息自发注意的认知倾向。SFON被视为其他数学聚焦倾向概念的基础, 但与自发数字聚焦(SAN)、自发阿拉伯数字聚焦(SFONS)和自发数量关系聚焦(SFOR)之间的联系仍需进一步明晰。作为数学表现的领域特异预测因子, 个体SFON的发展轨迹和作用机制是当前研究的重点所在。未来可从数学动机、数学焦虑等角度进一步探讨SFON的作用机制, 改良与创新SFON测量工具, 同时需深入推进家庭和学校场合的SFON干预研究。     

家庭环境、亲子依恋与青少年网络成瘾

本研究从北京、重庆和石家庄选取三所初中学校1038名初一到初三学生为被试,采用问卷调查的方式,探讨青少年的家庭环境、亲子依恋对其网络成瘾的影响及作用机制,以检验“人-情境交互作用理论”和“过程-个人-情境-时间”模型提出的理论观点。结果表明:(1)家庭环境和亲子依恋均与青少年的网络成瘾成显著负相关;(2)家庭环境中家庭亲密度对青少年网络成瘾有显著预测作用,父子依恋中的父子信任能显著负向预测青少年网络成瘾,母子依恋中的母子疏离能显著正向预测青少年网络成瘾;(3)家庭亲密度不仅直接影响青少年的网络成瘾,而且还通过母子疏离和父子信任间接影响青少年的网络成瘾,但母子疏离和父子信任所起的中介作用差异不显著。研究结果不仅说明了家庭环境对青少年心理行为发展的重要性,同时支持了“人-情境交互作用理论”和“过程-个人-情境-时间”模型提出的相应理论观点。     

大学生的冲动性特质与自杀意念的关系:一个有调节的中介模型

以应激-易感模型为依据考察冲动性特质与自杀意念的关系,并在此基础上提出一个有调节的中介模型,探讨负性生活事件影响的中介作用以及家庭环境的调节作用。采用巴瑞特冲动性量表、青少年生活事件量表、家庭环境量表、贝克自杀意念量表对902名大学生进行集体施测,旨在考察负性生活事件的影响对大学生冲动性特质与自杀意念的中介作用以及家庭环境的调节作用,结果表明:(1)冲动性特质和负性生活事件的影响能正向预测大学生的自杀意念;(2)负性生活事件的影响在冲动性特质和自杀意念之间起中介作用;(3)负性生活事件影响的中介作用和冲动性特质的直接作用受家庭环境的调节。这些结果对于综合解释环境与个体因素对自杀意念的作用与机制具有重要意义。