A cheap telemetric system for analyzing gait.

This study presents a technique for gait analysis, developed for the assessment of footfall timing and speed. The system in question consists of a transmitter, a receiver, a conductive walkway and a PC with the appropriate software.The technique was first tested for accuracy and repeatability with known signals, and was validated with a group of 20 healthy male adults (mean age = 34 years, S.D. = 5.5). The results thus obtained were similar to those reported in the literature for corresponding groups. Then, measurements on 10 children suffering from cerebral palsy (spastic hemiplegia) were performed. Gait analysis was carried out just before surgery and one year post-operatively. The results confirm the validity of the technique for measurements on orthopedic patients and its efficiency for functional evaluation of gait improvement after surgery.     

Left-side dominance for song discrimination in Bengalese finches (Lonchura striata var. domestica)

Male Bengalese finches are left-side dominant for the motor control of song in the sensorimotor nucleus (the high vocal center, or HVc) of the telencephalon. We examined whether perceptual discrimination of songs might also be lateralized in this species. Twelve male Bengalese finches were trained by operant conditioning to discriminate between a Bengalese finch song and a zebra finch song. Before training, the left HVc was lesioned in four birds and the right HVc was lesioned in four other birds. The remaining four birds were used as controls without surgery. Birds with a left HVc lesion required significantly more time to learn to discriminate between the two songs than did birds with a right HVc lesion or intact control birds. These results suggest that the left HVc is not only dominant for the motor control of song, but also for the perceptual discrimination of song. Accepted after revision: 11 September 2001 Electronic Publication     

脑出血中医药临床研究的困境与对策

脑出血为临床上的急危重症,目前缺乏有效的中医药治疗。本文从中药汤刺、中药注射剂及针灸三个方面阐述中医药治疗脑出血的临床现状,分析中医药治疗脑出血的优势与不足,从脑出血中医病名的确定、中医病机的多样性及中医重经验、轻理论,重哲学、轻医理等方面剖析中医药治疗脑出血临床困境的原因,并根据所述原因从脑出血相关中医病名研究、脑出血病机研究、中医药新型制弃】研究等方面探讨如何走出中医药治疗脑出血的临床研究困境。     

Leaving London: Three Autoethnographic Sketches

In this essay, I use autoethnographic sketching (Rambo, 2007 Rambo, C. (2007). Sketching as autoethnographic practice. Symbolic Interaction, 30(4), 531–542. doi:10.1525/si.2007.30.4.531[Crossref], [Web of Science ®] , [Google Scholar]) to explore the experience of arriving at and withdrawing from the London School of Economics and its impact on my life and work. I especially draw on the importance of close relationships with family, which helped me cope with and overcome limitations associated with my physical disability, cerebral palsy, as I work toward personal and professional fulfillment. It is my hope that these words will motivate others to better cope with and overcome challenges in pursuit of their goals.     

Are postural adjustments during reaching related to walking development in typically developing infants and infants at risk of cerebral palsy?

BackgroundIn typical development, postural adjustments during reaching change in the second half of infancy, including increasing rates of direction-specific adjustments. These changes are absent or different in infants at risk of cerebral palsy (CP). To discover whether these changes are related to acquisition of independent walking, we studied postural adjustments during reaching in infants before and after they learned to walk.MethodsTen typically developing (TD) infants and 11 infants at very high risk (VHR) of CP were assessed before and after they learned to walk. Reaching movements were elicited during supported sitting, while surface electromyography was recorded of arm, neck, and trunk muscles. Percentages of direction-specific adjustments (first level of control), and recruitment patterns and anticipatory activation (second level of control) were calculated.ResultsIn both groups, postural adjustments during reaching were similar before and after acquisition of independent walking. Direction-specificity increased with age in typically developing infants but not in VHR-infants.ConclusionIncreasing age rather than the transition to independent walking is associated with increasing direction-specificity of TD-infants during reaching while sitting, while infants at very high risk of CP show no increase in direction-specificity, suggesting that they gradually grow into a postural deficit.     

A Clinical Comparative Study Evaluating the Effect of Epilepsy Versus Adhd on Timed Cognitive Tasks in Children

Both children with epilepsy and children with ADHD may be characterized by slowing on reaction-time measurement. This is of particular interest, as neuropsychological assessment is often requested in the differential diagnosis between children with short non-convulsive epileptic seizures and children with ADHD. In this study we attempt to identify patterns of impairment on timed tasks that are specific for epilepsy, relative to ADHD. This study was an open, controlled parallel-group clinical investigation which included two groups of patients: 60 children with ADHD and 60 children with epilepsy. These children were compared with a control group (n =30) on two types of timed cognitive tasks: tasks with low information load (simple reaction-time measurement) and tasks with high information load (multiple decision reaction-time measurement). The simple reaction-time measurements show significant differences between ADHD and controls (all except for visual RT non-dominant hand) and between epilepsy and controls (only one test). No significant differences were found between epilepsy and ADHD. The two tests with high information load show significant slowing compared with the controls for epilepsy on the Binary Choice Reaction-Time Test and for ADHD on the Visual Searching Test. On both tests also the differences between epilepsy and ADHD are significant. The two tests in combination have a relatively satisfactory potential to classify the children with ADHD (75% correct classification) and the children with epilepsy (55% correct classification). We may conclude that complex reaction-time tests (i.e., timed tasks with high information load) have potential for assessing the differential impact of ADHD and epilepsy on attentional function. These tasks specifically reveal general slowing for children with epilepsy and slowing as an effect of failures of inhibitory self control on unstructured tasks for ADHD.     

Coping Strategies and Resolution in Mothers of Children With Cerebral Palsy

“Parental resolution” represents parents coming to terms with their child’s health condition. Differences in the use of coping strategies between mothers who were resolved versus unresolved to their child’s diagnosis was investigated, and a possible moderating effect of these strategies was explored. A strategy aimed at mobilizing the family to acquire and accept help (institutional, formal support) was shown to be a significant moderating variable, in a way that its more frequent use allowed mothers of children with better functional status (but not mothers of children with poorer functional status) to reach resolution.     

Age-related changes in visual pseudoneglect

Pseudoneglect is a slight but consistent leftward attentional bias commonly observed in healthy young populations, purportedly explained by right hemispheric dominance. It has been suggested that normal aging might be associated with a decline of the right hemisphere. According to this hypothesis, a few studies have shown that elderly tend to exhibit a rightward attentional bias in line bisection. In the present study, we tested this hypothesis in young and older participants using a perceptual landmark task. Results yield evidence for an age-related shift, from a strong attentional leftward bias in young adults toward a suppressed or even a reversed bias in the elderly. Right hemisphere impairment coupled to a left hemispheric compensation might explain the perceptual shift observed in older adults. However, a decline in corpus callosum function cannot be excluded. Alternatively, these results may be in agreement with the hypothesis of an age-related specific inhibition of return dysfunction, an overt attentional orienting mechanism, and/or a decrease of dopamine.