Slowly progressive pure dysgraphia with late apraxia of speech: a further variant of the focal cerebral degeneration

We report a longitudinal neuropsychological investigation of a patient with slowly progressive pure dysgraphia. Cognitive analysis of writing errors suggested a selective impairment of the graphemic buffer. After about seven years, the patient developed an apraxia of speech. No other linguistic or generalized cognitive impairment occurred subsequently, so that, twelve years after the beginning of the disease, the patient showed complete independence in daily life and still remained professionally active. Functional neuroimaging revealed hypoperfusion confined to left fronto-temporal lobe. This well-recognizable syndrome does not fit any of the cases described previously in the literature. This report therefore, adds another variant to heterogeneous clinical spectrum of focal neurodegenerative disorders, further suggesting the opportunity of their distinction from pathological processes leading to dementia.     

Islam,secularism and danger: a reconsideration of the link between religiosity,radicalism and rebellion in Central Asia

In equating political Islam with radicalism and rebellion against the state, security analysts make a number of assumptions about the religious, the secular and security. Within the Central Asian context, the discursive fusing of religiosity with radicalism produces a bogeyman in which national and foreign governments, although offering quite different countermeasures, have found a common enemy. This securitisation of Islam distorts our understanding of these movements whose approach is seldom ‘radical’ in form. We identify six claims which are axiomatic to both international and national secularist security discourses with respect to Islam in the region. We then demonstrate that popular Muslim discourse and political practice – in the findings of an original survey and ethnographic research in Kyrgyzstan and Tajikistan – provide a more complex picture than that found in elite discourses. While the six propositions can be refuted in objective terms, they remain relevant to how the problem is subjectively produced and reproduced in elite discourse and practice. As particular secularist claims about Islam, they inform national and international policies towards religious freedom and Islamic movements across Central Asia. Many of these themes appear in weaker and ambiguous forms in popular discourse and continue to limit Muslim political participation.     

Retiring the central executive

Reasoning, problem solving, comprehension, learning and retrieval, inhibition, switching, updating, or multitasking are often referred to as higher cognition, thought to require control processes or the use of a central executive. However, the concept of an executive controller begs the question of what is controlling the controller and so on, leading to an infinite hierarchy of executives or “homunculi”. In what is now a QJEP citation classic, Baddeley [Baddeley, A. D. (1996). Exploring the central executive. Quarterly Journal of Experimental Psychology, 49A, 5–28] referred to the concept of a central executive in cognition as a “conceptual ragbag” that acted as a placeholder umbrella term for aspects of cognition that are complex, were poorly understood at the time, and most likely involve several different cognitive functions working in concert. He suggested that with systematic empirical research, advances in understanding might progress sufficiently to allow the executive concept to be “sacked”. This article offers an overview of the 1996 article and of some subsequent systematic research and argues that after two decades of research, there is sufficient advance in understanding to suggest that executive control might arise from the interaction among multiple different functions in cognition that use different, but overlapping, brain networks. The article concludes that the central executive concept might now be offered a dignified retirement.     

Gonadal hormones and intrasexual aggressive behavior in female bank voles (Clethrionomys glareolus)

The effects of gonadal hormones on aggressive behavior in the female bank vole was investigated in 10 min home cage tests. Ovariectomized (ovx) or intact females injected with oil, with progesterone (P), with a mixture of progesterone and estrogen (P+E), or with testosterone (T) alone were confronted in a resident-intruder test with unfamiliar, nonoperated females as intruders. Intact females showed aggressive behavior more frequently than ovx females. Ovx females injected with P, with P+E, or with T made significantly more attacks, and these attacks lasted longer than those observed for oil-treated voles. The results indicate that P, the typical female hormone, is responsible for aggressive behavior in female bank voles; however, only T increased the duration of interfemale aggression. Aggr. Behav. 24:63–70, 1998. © 1998 Wiley-Liss, Inc.     

Lifespan changes in working memory in fragile X premutation males

Fragile X syndrome is the world’s most common hereditary cause of developmental delay in males and is now well characterized at the biological, brain and cognitive levels. The disorder is caused by the silencing of a single gene on the X chromosome, the FMR1 gene. The premutation (carrier) status, however, is less well documented but has an emerging literature that highlights a more subtle profile of executive cognitive deficiencies that mirror those reported in fully affected males. Rarely, however, has the issue of age-related declines in cognitive performance in premutation males been addressed. In the present study, we focus specifically on the cognitive domain of working memory and its subcomponents (verbal, spatial and central executive memory) and explore performance across a broad sample of premutation males aged 18–69 years matched on age and IQ to unaffected comparison males. We further tease apart the premutation status into those males with symptoms of the newly identified neurodegenerative disorder, the fragile X-associated tremor/ataxia syndrome (FXTAS) and those males currently symptom-free. Our findings indicate a specific vulnerability in premutation males on tasks that require simultaneous manipulation and storage of new information, so-called executive control of memory. Furthermore, this vulnerability appears to exist regardless of the presence of FXTAS symptoms. Males with FXTAS symptoms demonstrated a more general impairment encompassing phonological working memory in addition to central executive working memory. Among asymptomatic premutation males, we observed the novel finding of a relationship between increased CGG repeat size and impairment to central executive working memory.     

刺激持续时间对注意瞬脱影响的实验分离现象

通过三个实验,研究了注意瞬脱效应以便深入理解注意时间维度上的特性。实验一针对注意瞬脱效应（简称AB效应）和刺激持续显示时间（简称ED）之间的关系,发现SOA或者ED的延长能减小AB效应。实验二的结果再次证明ED的延长能减小AB效应,并且发现ED延长并没有伴随着对目标的加工速度的加快。实验三发现在目标与干扰项没有显著的特征差异时,AB效应随着ED延长而减小的现象消失了,即ED对AB效应的影响出现了实验性的分离。同时还证明突出显示可以通过加快对目标的反应速度来显著的减小AB效应,而且ED因素只有在目标具有突出的视觉特征时才能改变AB效应。     

阈下启动信息加工的心理机制

无意识如何影响人类的认知？或者说,无意识知觉在什么水平对人类的认知产生作用。由于方法和标准的限制,对上述问题的争论依然存在。当前对无意识知觉的研究主要集中在阈下启动的加工机制上,即启动刺激如何有效引发被试对目标刺激的加工。研究者提出知觉加工,中枢加工,反应加工以及行为触发等理论来解释阈下启动的心理加工机制。     

Verbal Style,Gubernatorial Strategies,and Legislative Success

This article examines the relationship between a governor's verbal style and his success in achieving his legislative goals. We add a measure of verbal style developed by Roderick Hart to a traditional model used by scholars of political chief executives to explain legislative success. We apply this model to the State of the State addresses of six governors of Florida who served between 1966 and 2006. Our findings reflect the validity of the truism “words matter.” Governors who use words and phrases that connote enthusiasm, activity, and realism are more successful in the legislative arena than those who do not.     

Multiple caregivers' touch interactions with young children among the Bofi foragers in Central Africa

The current study examined the use of three types of touch (caregiving, active social-affectionate, and passive social-affectionate) by caregivers with young children among the Bofi foragers, a seminomadic group of hunter-gatherers in Central Africa. With the purpose of providing a more holistic view of touch interactions in early childhood, compared to extant Western mother-centric views, this study documents stylistic touch patterns used by multiple caregivers (mother, father, adult relatives, and juvenile relatives) with Bofi forager children. Thirty-five Bofi forager children, between 18 and 59 months of age, and their various caregivers were naturalistically observed over 12 daylight hours using a focal child observational technique. Frequencies of each type of touch and the rank order of types of touch that children received were compared between caregivers and examined by child age and gender. Even though nonmaternal caregivers showed high physical involvement with children, mothers exemplified the highest level of involvement. Overall, passive social-affectionate touch was utilized the most by all types of caregivers. Mothers used more caregiving touch, and fathers and adult relatives had similar frequencies of caregiving touch and active social-affectionate touch. In contrast, juvenile relatives showed more active social-affectionate touch with focal children. This study highlights the importance of examining multiple caregivers and physical interactions when studying early childhood experiences. Furthermore, by focusing on multiple caregivers and multiple types of touch, this study provides a more thorough characterization of the touch experiences of young children than previous studies of touch. Finally, the current study exemplifies the value of considering non-Western populations when investigating touch interactions.     

Activation of cannabinoid CB1 receptors in the central amygdala impairs inhibitory avoidance memory consolidation via NMDA receptors

In the present study, we investigated the influence of bilateral intra-central amygdala (intra-CeA) microinjections of N-methyl-d-aspartate (NMDA) receptor agents on amnesia induced by a cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA). This study used a step-through inhibitory (passive) avoidance task to assess memory in adult male Wistar rats. The results showed that intra-CeA administration of ACPA (2 ng/rat) immediately after training decreased inhibitory avoidance (IA) memory consolidation as evidenced by a decrease in step-through latency on the test day, which was suggestive of drug-induced amnesia. Post-training intra-CeA microinjections of NMDA (0.0001, 0.001 and 0.01 μg/rat) did not affect IA memory consolidation. However co-administration of NMDA with ACPA (2 ng/rat) prevented the impairment of IA memory consolidation that was induced by ACPA. Although post-training intra-CeA administration of the NMDA receptor antagonist, d-(−)-2-amino-5-phosphonopentanoic acid (d-AP5; 0.01, 0.05 and 0.1 μg/rat) alone had no effect, its co-administration with an ineffective dose of ACPA (1 ng/rat) impaired IA memory consolidation. Post-training intra-CeA microinjection of an ineffective dose of d-AP5 (0.01 μg/rat) prevented an NMDA response to the impaired effect of ACPA. These results suggest that amnesia induced by intra-CeA administration of ACPA is at least partly mediated through an NMDA receptor mechanism in the Ce-A.