Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task

It is well established that genetic deletion or pharmacological inhibition of the CB₁ receptor disrupts extinction learning in aversive conditioning tasks, but not in appetitive tasks. Consistent with these findings is that genetic deletion or pharmacological inhibition of fatty acid amide hydrolase (FAAH), the primary catabolic enzyme of the endogenous cannabinoid anandamide (AEA), accelerates acquisition as well as extinction in aversive conditioning tasks. However, it is unknown whether FAAH blockade will affect acquisition in an appetitive conditioning task. Therefore, in the present study, we assessed FAAH (−/−) and (+/+) mice in appetitive and aversive Barnes maze conditioning procedures. Here we report that FAAH (−/−) mice displayed accelerated acquisition rates in an aversively-motivated, but not in the appetitively-motivated, Barnes maze task. The CB₁ receptor antagonist, rimonabant attenuated enhanced acquisition in the aversive procedure, consistent with the idea that elevated AEA levels mediate this apparent nootropic effect. These findings support the hypothesis that stimulation of the endocannabinoid system enhances learned behavior in aversive, but not appetitive, conditioning paradigms.     

The War Memoirs: Some origins of the thought of W. R. Bion

The work of W. R. Bion changed the shape of psychoanalytic theory in fundamental ways, one of the most important of which was Bion's insight into the nature of normal projective identification. No other psychoanalytic theorist has Bion's ability to represent the horrors of psychic abandonment and the converse, the absolute necessity of the presence of another mind for psychic survival. Through a discussion of Bion's War Memoirs 1917–1919 ( Bion, 1997 ), Attacks on linking and A theory of thinking (1993), this paper explores the link between war, masculinity, the maternal and Bion's sensitivity to the significance of everyday interpersonal contact. It is argued that Bion's apocalyptic experiences as a teenage tank commander gave him shattering insight into the extent to which mind is inter-mind, self is inter-self. Bion's life writing has the quality of survivor insight: 'And only I am escaped alone to tell thee' (Job 1: 14–19), as he returns repeatedly to the events of the day when he 'died ', 8 August 1918. His insight into the elemental passions nature of love, hate and mindlessness are borne of his experiences on the battlefield, and exquisitely crystallized in his repeated explorations of an encounter with a dying soldier.     

Ghost and self: Jung's paradigm shift and a response to Zinkin

Abstract :  Zinkin's lucid challenge to Jung makes perfect sense. Indeed, it is the implications of this 'making sense' that this paper addresses. For Zinkin's characterization of the 'self' takes it as a 'concept' requiring coherence; a variety of abstract non-contextual knowledge that itself has a mythical heritage. Moreover, Zinkin's refinement of Jung seeks to make his work fit for the scientific paradigm of modernity. In turn, modernity's paradigm owes much to Newton's notion of knowledge via reductionism. Here knowledge or investigation is divided up into the smallest possible units with the aim of eventually putting it all together into 'one' picture of scientific truth. Unfortunately, 'reductionism' does not do justice to the resonant possibilities of Jung's writing. These look forward to a new scientific paradigm of the twenty-first century, of the interactive 'field', emergence and complexity theory. The paper works paradoxically by discovering Zinkin's 'intersubjective self' after all, in two undervalued narratives by Jung, his doctoral thesis and a short late ghost story. However, in the ambivalences and radical fictional experimentation of these fascinating texts can be discerned an-Other self, one both  created and found .     

Equity Sensitivity Revisited: Contrasting Unidimensional and Multidimensional Approaches

Purpose  Past research has shown little support for direct relationships between equity sensitivity and various equity-relevant criteria. Recent work by Davison and Bing (J Manag Issues 20: 131–150, 2008) suggests that equity sensitivity consists of separate input- and outcome-focus dimensions and that these dimensions are associated with such criteria in an interactive fashion. The current study extends this research by theoretically strengthening and empirically testing their two-dimensional model. Design/methodology/approach  We surveyed adults who were working at least 30 h a week at three time periods to temporally separate measurement of predictors and criteria (n = 172). Findings  Results provide support for the two-dimensional model. Input and outcome focus interacted to explain variance in individuals’ satisfaction and self-reported job performance even after controlling for demographic characteristics, personality, and social desirability. By contrast, the original ESI only significantly predicted one of 10 dependent variables. Implications  Whereas a ratio has been historically used as the basis for evaluating equity, employing independent dimensions and investigating their interaction seems more appropriate to assess individuals’ equity sensitivity. The current study suggests a multidimensional measure of equity sensitivity may better reflect the original theoretical underpinnings of the construct. Originality/value  The current study enhances our understanding of equity theory in general, and equity sensitivity in particular, by drawing attention to the multidimensional nature of the equity sensitivity construct. In particular, it extends the work of Davison and Bing (J Manag Issues 20: 131–150, 2008) by revisiting Huseman et al.’s (Acad Manag Rev 12: 222–234, 1987) original conceptualization of equity sensitivity. In doing so, we broaden its utility as a potential unique predictor of organizationally relevant criteria.     

积极道德情绪和年龄对3-5岁幼儿安慰行为的影响

大量研究已经表明,消极道德情绪可以促进幼儿的亲社会行为,但积极道德情绪对幼儿亲社会行为的促进作用仍然缺乏全面探索。安慰行为是幼儿的典型亲社会行为,本研究使用实验法,采取想象启动和实际启动两种范式,考察积极道德情绪对3-5岁257名幼儿的安慰行为的影响。研究发现,幼儿的安慰行为发展具有年龄特征,4岁是幼儿安慰行为发展的转变关键期,更有意义的是,研究证明积极道德情绪对幼儿的安慰行为具有促进效应。本研究结果能为有效培养儿童的安慰行为提供有益建议。     

Effects of serotonin receptor agonists and antagonists on offensive aggression in mice

The effects of serotonin receptor agonists 5-methoxytryptamine and quipazine, and antagonist mianserin on resident-intruder offensive aggression were investigated. Both agonists reduced aggression. The fact that 5-methoxytryptamine preferentially binds to 5-HT-1 receptors strongly suggest that the decreased aggression with S-methoxytryptamine was related to stimulation of an inhibitory 5-HT-1 receptor. It is also suggested that the reduction in aggression with quipazine was related to quipazine's preferential binding to the 5-HT-1 receptor. The 5-HT-2 receptor antagonist mianserin reduced aggression suggesting that 5-HT-2 receptor blockade is inhibitory for aggression. Thus, two serotonin classes of receptors may be differentially involved in offensive aggression.     

中国近代心理学史上的丁韪良及其《性学举隅》

传教士丁韪良出于借心理学来传播宗教的目的在1898年出版了《性学举隅》, 这是融入了许多西方科学心理学知识的中文心理学著作。中国最早开设心理学课程的登州文会馆的两名毕业生在丁韪良撰写《性学举隅》过程中进行了笔述工作。丁韪良曾为益智书会撰写心理学教材但未完成, 益智书会转而出版了颜永京的《心灵学》(上本)。以丁韪良及其《性学举隅》为纽带, 19世纪后半叶中国近代心理学发展进程中的几个重要事件构成了一副较完整的历史图景, 反映出中国近代心理学的发展与宗教传播有着密切联系。《性学举隅》吸收了当时西方心理学前沿性的生理心理学知识, 向中国引介了催眠术和颅相学知识, 并对中国的“五官说”、“七情说”进行了修正与补充, 同时也借用了汉字的造字法来阐述其部分心理学观点。由于丁韪良向中国传播心理学是其宣传宗教思想的手段之一, 而颜永京译述海文原著的《心灵学》更倾向于向中国传播心理学这一学科, 强调了心理学与众多学科的联系和应用价值, 因此丁韪良在心理学术语创制上的历史功绩要逊于颜永京。颜永京于1882年将psychology翻译为“心才学”, 这是目前发现心理学学科的最早汉语翻译名称。     

公平加工的情境依赖性：来自ERP的证据

公平是人类社会生活的重要概念。大量研究采用最后通牒博弈, 发现人们具有不公平厌恶倾向, 即宁愿牺牲个人的经济利益, 也要拒绝不公平的分配提议。已有研究表明, 损失情境会增强不公平厌恶, 但其神经机制尚不清楚。本实验采用ERP技术, 运用最后通牒博弈范式, 考察两个情境因素：域(损失或获益)和博弈对象(人或计算机)对公平加工的影响。发现损失域下对不公平分配的拒绝率更高, 而博弈对象对决策行为无影响; 获益域下, 对家为人比对家为计算机诱发了更负的N1; 人机博弈时, 获益域比损失域诱发了更大的P2和LPP, 损失域比获益域、不公平提议比公平提议诱发了更大的N350, 而公平提议比不公平提议诱发了更大的LPP; 人际博弈时, 这些差异均不显著。这些结果表明, 对分配提议的大脑加工受博弈对象的调节, 人际博弈时, 对损益域、公平与不公平提议的加工类似, 而人机博弈时, 损失域和不公平提议涉及更多的抑制加工和冲突解决, 获益域和公平提议则更富动机性意义, 证实公平加工具有情境依赖性。     

Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food.

The hypothesis that mesolimbic dopamine is selectively involved in cocaine reinforcement was investigated in the rat. Animals were trained under a multiple schedule in which responding was reinforced by intravenous cocaine (0.75 mg/kg/injection) or food (45-mg pellets) under fixed-ratio 15 schedule requirements in alternate 30-min components of a 2-hr daily session. Infusion of the catecholaminergic neurotoxin 6-hydroxydopamine, but not the vehicle solution, into the region of the nucleus accumbens and olfactory tubercle produced selective reductions in cocaine self-administration without significantly altering responding maintained by food within the same sessions. This effect was reproduced in intact animals by substituting saline for cocaine in the self-administration component. These results support the hypothesis that the reinforcing effects of cocaine are dependent upon mesolimbic dopamine and demonstrate that cocaine self-administration can be disrupted in animals without altering behavior maintained by a nondrug reinforcer.