Parental illness intrusiveness and youth glycaemic control in type 1 diabetes: intergenerational associations and processes

Objective: This study examined associations between the functioning of youth with type 1 diabetes and their parents, including parenting dimensions as intervening mechanisms. The study adds to the existing literature by focusing on (1) the concept of parental illness intrusiveness; (2) the (understudied) periods of adolescence and emerging adulthood; and (3) maternal and paternal functioning. Design: Questionnaires were completed by 317 patient-mother dyads and 277 patient-father dyads. All patients (aged 14–25) had type 1 diabetes. The hypothesised model was compared to an alternative model using structural equation modelling. Main Outcome Measures: Youth reported on depressive symptoms and treatment adherence; Physicians provided HbA_1c-values. Parents reported on illness intrusiveness, depressive symptoms, and their child’s treatment adherence. Patients and parents reported on psychological control and overprotection. Results: The hypothesised path model had a good fit to the data. Parental illness intrusiveness was positively associated with depressive symptoms and both were positively related to overprotection and psychological control. Psychological control was positively related to patients’ depressive symptoms and negatively to treatment adherence. Poorer treatment adherence was associated with worse HbA_1c-values. Conclusion: These findings underscore the relevance of parental illness intrusiveness and emphasise the importance of mothers’ and fathers’ roles throughout adolescence and emerging adulthood.     

融合视角下的西方创造力系统观

创造力研究领域的学者已经在大C创造力、小C创造力以及创造力过程、人格、产品、创造力社会文化环境等不同角度进行了丰富的研究与理论的建构, 但体系纷繁, 观点各异, 往往让人难以抓住问题的重点, 我们则在梳理创造力定义的基础上, 将西方创造力理论从两个大方向上进行一定的梳理与思考, 一个是发展的角度(从微C创造力到小C创造力, 再到专业C创造力, 最后到大C创造力), 另一个是从微观到宏观联系的角度(从创造力的认知神经基础到创造力过程……一直到创造力的社会文化层面), 组成一个既联系又发展的坐标分类图, 因其与星系发展的过程有类似之处, 便将其比喻为星系发展模型, 以此来分析每个理论(主要包括Kaufman的4-C创造力模型、Csikszentmihalyi的创造力系统模型、Sternberg的创造力贡献推进理论、Amabile的创造力组成成分模型、Gl?veanu的5A创造力理论)的适用范围与界限, 以期为深入理解各个理论, 树立创造力整体观及为更进一步深入研究与应用做出一定的铺垫。     

Telling losses: Personality correlates and functions of bereavement narratives

How and why do bereaved individuals talk about their loss? What are the personality correlates and social consequences of different kinds of bereavement narratives? Two studies were conducted to answer these questions. In Study 1, participants from online bereavement support groups and memorial websites wrote bereavement narratives. Participants high in Conscientiousness told brief, factual narratives; participants high in Neuroticism told self-focused contamination narratives; and participants high in Extraversion told narratives for social reasons. In Study 2, undergraduate participants responded to twelve narratives from Study 1. Participants felt more sympathetic concern but more social awkwardness and less acceptance towards contamination narrators compared to redemption narrators. The role of personality in the telling and reception of bereavement stories, and social support after loss, is discussed.     

骨髓造血干细胞移植治疗自身免疫性疾病的进展

自身免疫疾病发病机制复杂,目前尚缺少有效的治疗方法。近年来发现造血干细胞移植可以通过免疫重建显著缓解甚至治愈自身免疫病。笔者对近年来造血干细胞移植治疗自身免疫病进行了介绍和综述,就其在1型糖尿病这一领域的研究进展进行了述评,探讨造血干细胞移植用于治疗自身免疫病的前景和待解决的问题。     

加拿大健康战略及其启示

介绍了加拿大健康战略出台的背号、战略愿景、目标、优先发展领域和具体的行动计划,在此基础上总结了加拿大健康战略实施过程的基本特点与经验,并结合我国的实际情况,提出了我国制定和实施“健康中国2020”战略的相关政策建议。     

Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats

Bilateral intradentate injections of 3.0 μg of colchicine induced a substantial loss of granule cells and damage to the overlying pyramidal cell layer in region CA1 in adult male Long-Evans rats. All rats with such lesions showed a significant associative learning deficit in an olfactory discrimination task, while being unimpaired in the procedural component of this task. Injection of a partial selective 5-HT₄ agonist (SL65.0155; 0.01 mg/kg, i.p., vs. saline) before the third of six training sessions enabled complete recovery of associative learning performance in the lesioned rats. Activation of 5-HT₄ receptors by a selective agonist such as SL65.0155 might therefore provide an opportunity to reduce learning and memory deficits associated with temporal lobe damage, and could be useful for the symptomatic treatment of memory dysfunctions related to pathological aging such as Alzheimer’s disease.     

Inhibition of mGluR1 and IP3Rs impairs long-term memory formation in young chicks

Calcium (Ca²⁺) is involved in a myriad of cellular functions in the brain including synaptic plasticity. However, the role of intracellular Ca²⁺ stores in memory processing remains poorly defined. The current study explored a role for glutamate-dependent intracellular Ca²⁺ release in memory processing via blockade of metabotropic glutamate receptor subtype 1 (mGluR1) and inositol (1,4,5)-trisphosphate receptors (IP₃Rs). Using a single-trial discrimination avoidance task developed for the young chick, administration of the specific and potent mGluR1 antagonist JNJ16259685 (500 nM, immediately post-training, ic), or the IP₃R antagonist Xestospongin C (5 μM, immediately post-training, ic), impaired retention from 90 min post-training. These findings are consistent with mGluR1 activating IP₃Rs to release intracellular Ca²⁺ required for long-term memory formation and have been interpreted within an LTP2 model. The consequences of different patterns of retention loss following ryanodine receptor (RyR) and IP₃R inhibition are discussed.     

Trace administration of vitamin E can retrieve and prevent UV-irradiation- and metal exposure-induced memory deficits in nematode Caenorhabditis elegans

Vitamin E (α-tocopherol), a lipid-soluble anti-oxidant, prevents the uncontrolled propagation of lipid peroxidation by free radicals. Nevertheless, there is weak or no evidence of a protective effect of previous vitamin E intake on cognitive function in humans. In the present study, we explored the thermosensation model to investigate the possible effects of vitamin E administration on memory behaviors in Caenorhabditis elegans. Administration of 100 and 200 μg/mL of vitamin E had no significant effects on the memory for different time intervals, whereas relatively high concentration (400 μg/mL) of vitamin E exposure shortened the extinction period of the association paradigm (food at 20 °C). Following the UV-irradiation, post-treatment with 200 μg/mL of vitamin E not only retrieved the UV-irradiation-induced memory deficits, but also enhanced the memory functions in UV-irradiating animals. Post-treatment with trace vitamin E could also ameliorate the memory deficits in metal (Al or Pb) exposed worms. In addition, pre-treatment with 200 μg/mL of vitamin E could effectively prevent the occurrence of memory deficits induced by metal exposure and UV-irradiation. Therefore, the close association may exist between trace dietary vitamin E intake and memory behaviors, and a specific response mechanism may be activated after the administration of vitamin E in stress-exposed animals. Moreover, treatment with 200 μg/mL of vitamin E could restore the memory deficits formed in the ncs-1 mutant worms, suggesting that exogenous treatment with trace vitamin E can largely mimic the function of NCS-1 in regulating the memory for thermosensation.     

Apodemus sylvaticus (LOXT) is a suitable mouse strain for testing spatial memory retention in the Morris water maze

Information on the difference in cognitive function between laboratory and wild-caught mice is anecdotal and this question has not been systematically studied. Moreover, studying a wild-caught mouse strain per se may add information to the repertoire of mouse strains available. We aimed to study spatial memory in a wild mouse strain (Apodemus sylvaticus, AS) as compared to two individual laboratory mouse strains.Male AS (n = 20), CD1 (n = 19) and C57BL/6J mice (n = 19), 12–14 weeks old, were used in the experiments. The Morris water maze (MWM) was used for determination of spatial memory and time spent in the target quadrant at time points 5 (D5) and 12 days (D12) was evaluated. During the acquisition phase latency to reach the platform and path length to reach the platform was evaluated.Following four training days on day 5 (D5), time spent in the target quadrant was highest in AS > CD1 > C57BL/6J (P < 0.006). On day 12 (D12), time spent in the target quadrant was significantly higher in AS than in both other strains (P < 0.001).All animals learned the task and during the acquisition phase, latency to reach the platform as well as path length decreased significantly in AS.It is concluded that the AS is the most suitable strain for the evaluation of spatial memory in the MWM and is presenting with memory retention superior to laboratory mouse strains CD1 and C57BL/6J.     

Rawls on Human Rights: A Review Essay

In this essay, I first evaluate the conceptual analysis of human rights by Wilfried Hinsch and Markus Stepanians. Next I criticize Allen Buchanan’s claim that Rawls did not address basic human interests/capabilities theories of human nature. I argue Buchanan is doubly mistaken when he claims that John Rawls sought to avoid such theories because they are comprehensive doctrines. Then I evaluate David Reidy’s defense of Rawls, while questioning his efforts to show how Rawls’s list of human rights could be expanded. Finally, I accept James Nickel’s argument that Rawls has tied human rights too closely to intervention on their behalf. However, I reject his, and by implication Rawls’s, refusal to accept a two-tiered approach to human rights.