背景应激对静息态下大脑自发神经活动的影响

本研究试图探究背景应激对应激相关大脑自发神经活动的影响。使用日常应激水平作为背景应激的量化指标,同时,使用静息态fMRI技术采集了个体在静息态下的大脑自发神经活动,并使用局部一致性(ReHo)作为指标。结果发现,背景应激越高的个体,右侧海马(扩展到丘脑和脑干)静息态下局部一致性水平越高。结果提示,经历了高背景应激的个体会表现出边缘系统脑区自发神经活动的持续活跃状态。     

Socially induced renal pathology of captive wild rats (Rattus villosissimus)

Long-haired rats, Rattus villosissimus, were studied in large cages. Groups of adult rats (each of 3 males, or 1 male and 2 females) were observed during intermittent encounters with a male intruder for up to 9 days. Two further groups, each of 8 males and 8 females, were maintained for 70 days without introduction of intruders. Controls were kept in small cages in which intolerant behavior was rare. Behavior during attack resembled that of male R. norvegicus, but social relationships were less stable. Only observations on males are described in detail. Some rats collapsed under attack, though unwounded, and died when not removed. Collapse occurred sometimes after a few hours, but sometimes after many days of exposure. Exposure to attack was accompanied by a decline in body weight and by some adrenal hypertrophy. Two kinds of renal pathology are described: focal glomerular hypercellularity (FGH), probably due to glomerulonephritis, and dilated distal convoluted tubules. Neither condition occurred in the controls. FGH occurred in 3 of 12 rats (25%) that remained apparently healthy during the 9 days of continuous exposure, in 21 of 23 intruders (91%) that were exposed to intermittent attack over 9 days or less without becoming debilitated, and in 8 of 11 such rats (73%) that collapsed. All rats examined from 70-day colonies had FGH, whether collapsed or not. Dilated tubules occurred in 6 of 32 intruders (19%) exposed to intermittent attack, and in 2 of 6 animals that collapsed during 70 days of exposure. Renal pathology, especially glomerulonephritis, was therefore a correlate of social intolerance; but there was no evidence that it was a significant cause of death.     

注意促进运动知觉判断的时间进程

本研究通过控制深度视觉线索, 分析3D SFM (structure from motion)知觉中的眼动特征, 探讨注意对SFM知觉判断的影响及其时间进程。结果显示, 有线索刺激比模糊刺激的判断更加快、更加肯定(百分比更高); 眼睛移动方向和微眼跳方向都分别与知觉判断的运动方向具有一致性; 微眼跳频次、峰速度和幅度也都分别表现出深度线索的促进效应。实验结果表明, SFM知觉过程大致分为速度计算和构建三维结构两个阶段; 注意对SFM知觉的调节作用主要发生在构建三维结构阶段; 注意从150 ms开始指向选择对象, 驻留持续约200 ms后, 从局部运动矢量流转移到整体运动方向的知觉判断。     

Le procès pénal du Mediator® et ses implications concernant les différents ordres de juridiction

The long-awaited judgment issued about the Mediator case by the 31st criminal court of the Tribunal de grande instance de Paris will not be the last one. The public prosecutor, as well as Servier and some of the victims have called for the appeal. Nevertheless, the number of victims reflects the extent of damage caused by this medicine. The complexity of the procedure highlights the specificities of the civil and administrative jurisdictions, as well as the transactional process. The purpose is to study the main points related to this articulation.     

外语焦虑量表(FLCAS)在大学生中的测试报告

本研究通过外语课堂焦虑量表（FLCAS）在我国大学生中初步应用及因素分析,结果发现：（1）中文版FLCAS具有较好的信度和效度,可用于今后的有关研究或实际工作。（2）我国大学生在学习英语过程中产生的焦虑主要包括担心、紧张不安、害怕说英语和害怕课堂提问等四个方面;（3）女大学生的外语焦虑水平显著低于男大学生,这可能女性的语言能力相对较强有关;（4）我国非英语专业大学生的外语学习焦虑水平显著低于国外学习其它外语的大学生,这可能跟他们外语学习的经历较长有关。     

中国人人格量表（QZPS）的编制过程与初步结果

旨在编制能够反映中国人人格结构特点的中国人人格量表（QZPS）。文中首先分析了直接采用或修订西方人格量表的问题和潜在危险,以及目前国内使用的各种人格量表存在的局限;按照人格研究的“词汇学假设”,根据杨国枢和王登峰（1999）以及后来的研究所确定的中国人人格结构的七因素模型,提出了QZPS的编制原则和操作程序。按照人格特质形容词的含义编写测量项目,并根据小因素和大因素的含义对项目进行修改,初步确定了1600多个项目。经2280名被试的评定,初步筛选出409个项目。再经1099名被试评定,确定了215个项目构成QZPS,测量中国人人格的7个维度和18个小因素。文中还报告了对QZPS的项目分析的结果     

汉语图片命名中获得年龄的作用

不同语种的研究都发现获得年龄是影响图片命名和词汇命名的重要因素。该研究对汉语图片命名中获得年龄的作用进行了初步探讨。研究分为两部分,第一部分让20名大学生对187幅选自Snodgrass和Vanderwart图片集的线条画的名称的获得年龄进行了评定;第二部分以该187幅图片为刺激,30名大学生被试对图片进行命名反应。以命名反应时为因变量,采用多重回归分析,发现除了名称一致性和概念熟悉性,获得年龄是图片命名反应时的主要预测指标,并没有发现词频的效应。文章对此结果进行了讨论。     

The Nature and Meaning of the Near-Death Experience for Patients and Critical Care Nurses

This study was designed to develop a conceptual framework for the near-death experience (NDE), reflecting its nature and meaning for the patient and the critical care nurse. The study used naturalistic inquiry to examine the question: What is the nature and meaning of an NDE and how has it influenced the individual's view of the self, the future, and feelings and beliefs about life and death? The NDE Scale (Greyson, 1983) was used with patients and semi-structured interview guides were used with both nurses and patients to explore the NDE from a comprehensive perspective. An NDE was defined as the report of “unusual” recollections associated with a period of unconsciousness during either serious illness or injury, or resuscitation from a cardiac or respiratory arrest. The sample included 12 patients who experienced an NDE and 19 nurses who cared for patients who experienced NDEs. This study highlighted the emotional aspects of the NDE. Patients described how the NDE transformed their lives and nurses reported how their experiences with patients changed them personally and professionally.     

Septal infusions of glucose or pyruvate,but not fructose,produce avoidance deficits when co-infused with the GABA agonist muscimol

Although glucose typically enhances memory or reverses memory deficits, glucose can also produce memory deficits when co-infused with the gamma-aminobutyric acid (GABA) agonist muscimol into the medial septum (Parent & Gold, 1997; Parent, Laurey, Wilkniss, & Gold, 1997). To date the mechanisms underlying the memory-impairing interaction between GABA and glucose remain unknown. Here we investigate whether this effect is the result of hyperosmolar conditions or may involve glucose metabolism. Male Sprague-Dawley rats were given one-trial inhibitory avoidance training after receiving septal infusions of vehicle (phosphate-buffered saline, 0.5 microl), the GABA(A) agonist muscimol (3 nmol), glucose (16.5, 33, or 66 nmol), fructose (33 nmol), pyruvate (33 nmol), or a solution containing muscimol combined with glucose, fructose, or pyruvate. Retention performance was tested 48 h later. Infusions of glucose, pyruvate, fructose, or muscimol alone did not affect retention performance. However, co-infusions of all doses of glucose (16.5, 33, or 66 nmol) or the glycolytic end product pyruvate with muscimol impaired retention performance. Co-infusions of fructose with muscimol did not affect retention performance. These results suggest that the memory-impairing interaction between glucose and muscimol does not result from hyperosmolar conditions, because equiosmolar concentrations of fructose do not mimic the effects of glucose and the memory deficits do not vary as a function of glucose concentration. The finding that pyruvate mimicked the effects of glucose and impaired memory when combined with muscimol suggests that glucose metabolism may be involved in the memory-impairing interaction between glucose and GABA(A) receptors in the medial septum.