LKB1蛋白在食管鳞癌组织中的表达及意义

为了探讨肝激酶B1（LKB1）蛋白在食管鳞癌组织中的表达水平及其与食管鳞癌临床特征及生存期的关系,应用免疫组化方法检测120例食管鳞癌患者组织中LKB1蛋白表达情况并对诸多临床特征进行相关性分析研究,发现LKB1蛋白在食管癌旁正常组织的阳性表达率高于癌组织;LKB1蛋白表达与患者年龄、性别、肿瘤部位、病变长度及浸润深度无关而与分化程度、淋巴结转移及临床分期（TNM）相关,且LKB1蛋白阴性组预后较阳性组差.可见LKB1视为抑癌基因影响食管鳞癌的预后,可能成为食管鳞癌新型的临床预后指标之一.     

Can Muslims Befriend Non-Muslims? Debating al-walāʾ wa-al-barāʾ (Loyalty and Disavowal) in Theory and Practice

This article analyzes the polemic on the concept of al-walā? wa-al-barā? (commonly translated as “loyalty and disavowal”). While existing academic literature focuses on the usages of this concept by jihad activists, the article centers on the role “loyalty and disavowal” plays in debates between contemporary salafī and wasa?ī jurists and theologians, specifically in their conflicting agendas for Muslims living as minorities. Salafīs, relying on several qur'anic verses and Prophetic traditions, promote an understanding of “loyalty and disavowal” that requires Muslims to refrain from befriending or loving non-Muslims, or imitating their beliefs and customs. Relying on counter-verses and traditions, in particular Q 60.8, wasa?īs have interpreted the concept of “loyalty and disavowal” more narrowly, arguing that it applies only to non-Muslims who fight against Muslims; as part of their integration-oriented doctrine for Muslims in the West, they have in recent years dedicated considerable efforts to refuting the salafī interpretation of al-walā? wa-al-barā?. The article examines the juristic methodologies utilized in the debate, and how it has affected religious decisions (fatwās) on Islamic life in Western societies.     

Tisha B’Av, “Ghetto Day,” and producing “authentic” Jews at postwar Jewish summer camps

The postwar period brought sweeping changes for American Jews. Communal socioeconomic transitions and the aftermath of the Holocaust triggered intense anxieties among Jewish leaders regarding the preservation of so-called Jewish “authenticity,” and to an increased focus on the moulding of American Jewish youth. This article considers how Jewish summer camps used Tisha B’Av and secular, alternative memorial days, to lead campers toward various, ideologically imbued visions of Jewish authenticity. Through fostering an aura of tragedy in what was otherwise a world of play, songs, and enjoyment, Jewish educators used memorial days as transformative educational tools. Though camps’ ceremonies looked remarkably similar, often including a carefully crafted sombre atmosphere, dirges, and responsive readings, the message of the days proved malleable to different ideological perspectives. This article considers how Zionist, Yiddishist, Reform and Conservative camps came to use memorial days to produce “real,” “ideal,” or “authentic” Jews in accordance with their ideological visions in the decades immediately following the Holocaust.     

Motivation for Physical Activity among Hawaiian,Japanese, and Filipino University Students in Hawaii

The purpose is to identify the motivations and barriers to physical activity (PA) among the three largest ethnic groups in Hawaii (Hawaiians/part-Hawaiians, Japanese, and Filipinos). University of Hawai'i students (N = 32, aged 18+) self-identified as one of those ethnicities participated in focus groups. There are more common themes than ethnic-specific variations in factors influencing PA. PA is understood as exercise among all groups; leisure time PA like running and surfing are common activities. Results were more similar among Hawaiian and Japanese than with Filipino participants. The findings offer an opportunity for improving cross-cultural and culture-specific PA interventions for those ethnicities.     

The Developmental Activities of Elite Ice Hockey Players

The purpose of this study was to analyze the development of four 20 year-old elite hockey players through an in-depth examination of their sporting activities. The theoretical frameworkof deliberate practice (Ericsson, Krampe, & Tesch-Romer, 1993) and the notion of deliberate play (Côté, 1999) served as the theoretical foundations. Interviews were conducted to providea longitudinal and detailed account of each participant.s involvement in various sporting activities. The interviewer asked questions about the conditions and sporting activities for eachyear of development. The data obtained were validated through independent interviews conducted with three parents of three different athletes. The results were consistent with Côté.s(1999) three stages of development in sport: the sampling (age 6.12), specializing (age 13. 15), and investment (age 16+) years.     

Hostilidad,patrón de conducta tipo A y reactividad cardíaca

Resumen

La presente investigación tuvo como objetivo estudiar el efecto de la hostilidad autoinformada en la reactividad cardíaca de sujetos Tipo A/B. Los sujetos fueron 40 estudiantes varones repartidos en cuatro grupos: (1) Tipo A con alta Hostilidad, (2) Tipo A con baja Hostilidad, (3) Tipo B con alta Hostilidad y (4) Tipo B con baja Hostilidad. Todos ellos pasaron por tres pruebas de reactividad psicofisiológica: El Test de la Respuesta Cardíaca de Defensa ante estimulación auditiva intensa, una Tarea de Aritmética Mental y una Tarea de Juego de Vídeo Competitivo. La variable dependiente registrada fue la tasa cardíaca. Los resultados indican que en las tres pruebas no se observan diferencias en la reactividad de la tasa cardíaca entre sujetos Tipo A y B con alta Hostilidad autoinformada. Sin embargo, sí se observan diferencias entre sujetos Tipo A y B con baja Hostilidad autoinformada, siendo los sujetos Tipo A los que muestran mayores incrementos en tasa cardíaca durante la Respuesta Cardíaca de Defensa y el Juego de Vídeo Competitivo. En la Tarea de Aritmética Mental se observa esta tendencia, aunque no llegan a ser diferencias significativa s. Estos resultados sugieren que la supresión o negación de la hostilidad en sujetos Tipo A está asociada con un incremento en la reactividad cardiovascular.     

exploring drug users' illness representations of hiv,hepatitis b and hepatitis c using repertory grids

Abstract

Hepatitis B and C viruses are more prevalent among injecting drug users than HIV. This study explored drug users' illness representations of hepatitis B and C using repertory grid methodology. Initially, nine drug users were presented with six elements including hepatitis B and C, and HIV. Constructs were elicited via the sequential form variation of the method of triads. Elements were rated on elicited constructs using a five-point scale, and analyzed using “Flexigrid”. In a second quantitative research stage, 52 drug users were presented with six elements and supplied constructs. Results of the first stage indicated participants were able to generate constructs relating to Leventhal et al.'s (1980) features of illness representations. Most constructs, however, were causal in nature. Participants perceived hepatitis B, C and HIV similarly along the causal component. This similarity on the causal component was largely replicated in the second research stage. Participants, however, distinguished HIV from hepatitis B and C along serious, cure and timeline features. Participants did not distinguish hepatitis B from hepatitis C. The implications of these results for health promotion are discussed.     

A case of subcortical dementia due to sarcoidosis of the hypothalamus and fornices

A patient with sarcoidosis involving predominantly the hypothalamus and fornices was evaluated for dementia. He showed a relative sparing of fund of knowledge and orientation. Memory skills, particularly short-term memory, were severely impaired. Behavioral changes included apathy and a lack of spontaneity. Insight was relatively preserved. The pattern of his deficits showed some similarities to the pattern reported in patients with Huntington's disease and was different from that described in Alzheimer's disease. The dementia caused by subcortical pathology may differ in important respects from that caused by diffuse cortical dysfunction.     

Psychometric and Piagetian intelligences: Toward resolution of controversy

Whether “psychometric” and “Piagetian” kinds of intelligence, as measured by instruments designed to measure these constructs, are the same or different is regarded as a question of whether they have the same or different courses of development with age. While factor analysis may not be fully adequate for investigation of this question, use of this technique with variables reflecting chronological age variation must involve elimination of the age effect in order to assess relations among the constructs measured. Humphreys and Parsons (1979) were justified in partialing out age in their reanalysis of a study by Stephens, McLaughlin, Miller, and Glass (1972), to show that the two constructs are highly correlated and possibly identical in the sample studied. Reanalyses of studies by DeVries and Kohlberg (1977) and by DeVries (1974) yield somewhat conflicting results on the identity between psychometric and Piagetian intelligences. The former study does not yield a convincing separation between them, whereas the latter suggests that they can be distinguished, though substantially correlated and both loaded with a general factor. Problems in further investigating the issue are discussed.