Composition of brain oscillations and their functions in the maintenance of auditory,visual and audio–visual speech percepts: an exploratory study

In the present exploratory study based on 7 subjects, we examined the composition of magnetoencephalographic (MEG) brain oscillations induced by the presentation of an auditory, visual, and audio-visual stimulus (a talking face) using an oddball paradigm. The composition of brain oscillations were assessed here by analyzing the probability-classification of short-term MEG spectral patterns. The probability index for particular brain oscillations being elicited was dependent on the type and the modality of the sensory percept. The maintenance of the integrated audio-visual percept was accompanied by the unique composition of distributed brain oscillations typical of auditory and visual modality, and the contribution of brain oscillations characteristic for visual modality was dominant. Oscillations around 20 Hz were characteristic for the maintenance of integrated audio-visual percept. Identifying the actual composition of brain oscillations allowed us (1) to distinguish two subjectively/consciously identical mental percepts, and (2) to characterize the types of brain functions involved in the maintenance of the multi-sensory percept.     

Etiologic Subtypes of Attention-Deficit/Hyperactivity Disorder: Brain Imaging, Molecular Genetic and Environmental Factors and the Dopamine Hypothesis

Multiple theories of Attention-Deficit/Hyper- activity Disorder (ADHD) have been proposed, but one that has stood the test of time is the dopamine deficit theory. We review the narrow literature from recent brain imaging and molecular genetic studies that has improved our understanding of the role of dopamine in manifestation of symptoms of ADHD, performance deficits on neuropsychological tasks, and response to stimulant medication that constitutes the most common treatment of this disorder. First, we consider evidence of the presence of dopamine deficits based on the recent literature that (1) confirms abnormalities in dopamine-modulated frontal-striatal circuits, reflected by size (smaller-than-average components) and function (hypoactivation); (2) clarifies the agonist effects of stimulant medication on dopaminergic mechanisms at the synaptic and circuit level of analysis; and (3) challenges the most-widely accepted ADHD-related neural abnormality in the dopamine system (higher-than-normal dopamine transporter [DAT] density). Second, we discuss possible genetic etiologies of dopamine deficits based on recent molecular genetic literature, including (1) multiple replications that confirm the association of ADHD with candidate genes related to the dopamine receptor D4 (DRD4) and the DAT; (2) replication of differences in performance of neuropsychological tasks as a function of the DRD4 genotype; and (3) multiple genome-wide linkage scans that demonstrate the limitations of this method when applied to complex disorders but implicate additional genes that may contribute to the genetic basis of ADHD. Third, we review possible environmental etiologies of dopamine deficits based on recent studies of (1) toxic substances that may affect the dopamine system in early development and contribute substantially to the etiology of ADHD; (2) fetal adaptations in dopamine systems in response to stress that may alter early development with lasting effects, as proposed by the developmental origins of health and disease hypothesis; and (3) gene-environment interactions that may moderate selective damage or adaptation of dopamine neurons. Based on these reviews, we identify critical issues about etiologic subtypes of ADHD that may involve dopamine, discuss methods that could be used to address these issues, and review old and new theories that may direct research in this area in the future.     

实验性恶心与呕吐——大脑皮层与内脏相关研究的新途径

大脑皮层与内脏关系的脑机制是揭示心身疾病和心理疾病的重要依据。本文综述了经典条件学习与期待性恶心与呕吐的关系以及实验性恶心与呕吐的研究方法。作者认为,实验性恶心与呕吐结合脑成像技术是研究大脑皮层与内脏关系神经机制的重要途径。     

Angel or demon? Self-monitoring differences in the mental representations of current versus former romantic partners

We investigated whether high and low self-monitors had (a) segregated/integrated and (b) uniformly favorable (angelic)/uniformly unfavorable (demonic) mental representations of actual romantic partners. Self-monitoring was assessed using the 25-item Self-Monitoring Scale and the structure of mental representations was calculated using a modified segregation/integration measure. In Study 1, low self-monitors were more likely than high self-monitors to have (a) segregated and (b) disproportionally favorable mental representations of their current romantic partners. In Study 2, low self-monitors were more likely than high self-monitors to have (a) segregated and (b) generally unfavorable mental representations of their former romantic partners. Self-monitoring differences were not moderated in either study by relationship longevity or conflict.     

Presence of ε-martensite as an intermediate phase during the strain-induced transformation of SUS304 stainless steel

We have investigated the formation process of α′-martensite from the γ-phase induced by external strain using in situ synchrotron diffraction experiments, combined with Lorentz transmission electron microscopy (TEM) and high-resolution TEM observations. It is clearly demonstrated that ε-martensite with hexagonal symmetry appears as an intermediate structure during the plastic deformation of SUS304 stainless steel. In addition to stacking faults and dislocations, interfaces between the twin structures presumably play a key role in the formation of ε-martensite.     

Prosodic processing by children: an fMRI study

Prosodic information in the speech signal carries information about linguistic structure as well as emotional content. Although children are known to use prosodic information from infancy onward to assist linguistic decoding, the brain correlates of this skill in childhood have not yet been the subject of study. Brain activation associated with processing of linguistic prosody was examined in a study of 284 normally developing children between the ages of 5 and 18 years. Children listened to low-pass filtered sentences and were asked to detect those that matched a target sentence. fMRI scanning revealed multiple regions of activation that predicted behavioral performance, independent of age-related changes in activation. Likewise, age-related changes in task activation were found that were independent of differences in task accuracy. The overall pattern of activation is interpreted in light of task demands and factors that may underlie age-related changes in task performance.     

语言与数量认知关系的新认识

数量认知研究近年有长足发展。文章从新近提出的独立于语言的两个数量表征核心系统,语言与精确数量运算,语言与算术事实的储存,语言对儿童早期数概念发展的影响,语言与数量认知关系的最新脑科学证据,以及语言在数量认知模型中的角色等方面,介绍和评述了人类存在依赖和不依赖语言的两级数量能力的新认识。对于是否还存在其它不依赖语言的理解数量的系统,以及这些非语言数量表征系统的认知机制,文章认为有待进一步研究     

Effect of mindfulness meditation on brain–computer interface performance

Electroencephalogram based brain–computer interfaces (BCIs) enable stroke and motor neuron disease patients to communicate and control devices. Mindfulness meditation has been claimed to enhance metacognitive regulation. The current study explores whether mindfulness meditation training can thus improve the performance of BCI users. To eliminate the possibility of expectation of improvement influencing the results, we introduced a music training condition. A norming study found that both meditation and music interventions elicited clear expectations for improvement on the BCI task, with the strength of expectation being closely matched. In the main 12 week intervention study, seventy-six healthy volunteers were randomly assigned to three groups: a meditation training group; a music training group; and a no treatment control group. The mindfulness meditation training group obtained a significantly higher BCI accuracy compared to both the music training and no-treatment control groups after the intervention, indicating effects of meditation above and beyond expectancy effects.     

辛苦所得与意外所得的非理性消费偏差：基于IAT检测和ERP证据

不同来源的财富因其在人们心理的权重差异会导致对其消费态度与方式的不同。前人运用一系列行为实验已发现意外所得更容易消费、辛苦所得则不容易消费。基于心理账户和内隐社会认知等理论, 运用IAT和ERP考察财富的意外所得与辛苦所得在人们心理引起的内在消费偏差, 进而对内隐消费态度和脑加工机制进行间接检测。IAT研究结果表明, 意外所得与容易消费的联结更加紧密, 辛苦所得与不易消费的联结更加紧密, 从内隐层面验证了前人的行为研究结论; ERP研究结果发现辛苦所得与意外所得这两个不同收入来源可能建立了不同脑加工机制, 且在P3和LPC成分得到反映, P3成分可能是反映辛苦所得组偏好难消费型消费方式的ERP成分, LPC反映了意外所得收入条件下个体偏好易消费型消费方式的特点。     

Relationships,Environment, and the Brain: How Emerging Research is Changing What We Know about the Impact of Families on Human Development

Recent research is providing family therapists with new information about the complex interaction between an individual's biological makeup and his/her social and physical environment. Family and social relationships, particularly during sensitive periods early in life, can affect a child's biological foundation. Additionally, stress during the early years can have a lasting effect on an individual's physical and mental health and contribute to the onset of severe mental illness. Community programs have been developed to intervene early with families who have an at‐risk child to prevent or minimize the onset of mental illness including providing partnerships with at‐risk mothers of infants to shape attachment relationships. Programs are also developing individual and family interventions to prevent the onset of psychosis. Practicing family therapists can incorporate emerging neuroscience and early intervention research and leverage the growing base of community programs to enhance the effectiveness and sustainability of mental health outcomes for clients. Additionally, family therapy education programs should broaden student training to incorporate the growing body of information about how family relationships affect individual mental health development.