实验性恶心与呕吐——大脑皮层与内脏相关研究的新途径

大脑皮层与内脏关系的脑机制是揭示心身疾病和心理疾病的重要依据。本文综述了经典条件学习与期待性恶心与呕吐的关系以及实验性恶心与呕吐的研究方法。作者认为,实验性恶心与呕吐结合脑成像技术是研究大脑皮层与内脏关系神经机制的重要途径。     

Notes for a dialogue between psychoanalysis and neuroscience1

The author postulates that the dialogue between psychoanalysis and neuroscience is based on the assumption that both deal with virtual structures. They are two facets of the same noumenal reality, but with different phenomenal realities, and it is possible to use metapsychology as a lingua franca to develop communication between the two fi elds. In the second part of the paper, the author refl ects on the results of recent neurophysiological research which seem to offer to psychoanalysis possibilities for fi nding an anatomical‐physiological correlate of some well‐known psychic phenomena and mechanisms, such as imitation, introjection, identifi cation, empathy, identity, mother‐child communication, learning, social communication and the analyst‐patient relationship. Particular neurons, called mirror neurons, have been located in the F5 area of baboons' brains. They are also present in man's brain within Broca's area. These neurons activate our motor system during both the performance of actions and the observation of actions performed by others giving rise to an automatic response, a sort of simulation or, rather, imitation, as the process is not intentional, but automatic and unaware, that is, unconscious.     

Identity,Indiscernibility, and Philosophical Claims

The concept of indiscernibility in a structure is analysed with the aim of emphasizing that in asserting that two objects are indiscernible, it is useful to consider these objects as members of (the domain of) a structure. A case for this usefulness is presented by examining the consequences of this view to the philosophical discussion on identity and indiscernibility in quantum theory.     

Structural Realism, Scientific Change, and Partial Structures

Scientific change has two important dimensions: conceptual change and structural change. In this paper, I argue that the existence of conceptual change brings serious difficulties for scientific realism, and the existence of structural change makes structural realism look quite implausible. I then sketch an alternative account of scientific change, in terms of partial structures, that accommodates both conceptual and structural changes. The proposal, however, is not realist, and supports a structuralist version of van Fraassen’s constructive empiricism (structural empiricism).     

Persons,animals, and identity

The paper is concerned with how neo-Lockean accounts of personal identity should respond to the challenge of animalist accounts. Neo-Lockean accounts that hold that persons can change bodies via brain transplants or cerebrum transplants are committed to the prima facie counterintuitive denial that a person is an (biologically individuated) animal. This counterintuitiveness can be defused by holding that a person is biological animal (on neo-Lockean views) if the “is” is the “is” of constitution rather than the “is” of identity, and that a person is identical with an animal in a sense of “animal” different from that which requires the persistence conditions of animals to be biological. Another challenge is the “too many minds problem”: if persons and their coincident biological animals share the same physical properties, and mental properties supervene on physical properties, the biological animal will share the mental properties of the person, and so should itself be a person. The response to this invokes a distinction between “thin” properties, which are shared by coincident entities, and “thick” properties which are not so shared. Mental properties, and their physical realizers, are thick, not thin, so are not properties persons share with their bodies or biological animals. The paper rebuts the objection that neo-Lockean accounts cannot explain how persons can have physical properties. To meet a further problem it is argued that the biological properties of persons and those of biological animals are different because of differences in their causal profiles.     

Relationship of temporal lobe volumes to neuropsychological test performance in healthy children

Ecological validity of neuropsychological assessment includes the ability of tests to predict real-world functioning and/or covary with brain structures. Studies have examined the relationship between adaptive skills and test performance, with less focus on the association between regional brain volumes and neurobehavioral function in healthy children. The present study examined the relationship between temporal lobe gray matter volumes and performance on two neuropsychological tests hypothesized to measure temporal lobe functioning (visual perception-VP; peabody picture vocabulary test, third edition-PPVT-III) in 48 healthy children ages 5-18 years. After controlling for age and gender, left and right temporal and left occipital volumes were significant predictors of VP. Left and right frontal and temporal volumes were significant predictors of PPVT-III. Temporal volume emerged as the strongest lobar correlate with both tests. These results provide convergent and discriminant validity supporting VP as a measure of the "what" system; but suggest the PPVT-III as a complex measure of receptive vocabulary, potentially involving executive function demands.     

Age-Related Differences in Identity Style: A Cross-Sectional Analysis

The Identity Style Inventory–Revised for a Sixth-Grade Reading Level (ISI-6G) was administered to samples of community college students (N = 99) and middle school and high school students (N = 320). Tests of between-groups differences indicated that the college sample had a significantly lower mean diffuse-avoidant score on the ISI-6G than the middle and high school sample. In terms of actual assignment to identity styles, college students were significantly more likely to be classified as informational or normative, while the younger students were more likely to be diffuse-avoidant. The mean ages of participants for each of the three identity styles were compared, and it was found that diffuse-avoidant participants had the lowest mean age (15.54 years), while individuals with an informational orientation had the highest mean age (17.20 years). Results suggest that, in general, identity style evolves with age and maturity and the general trajectory or progression involves movement away from a diffuse-avoidant orientation. Findings are discussed in terms of current knowledge of neurocognitive development during adolescence and early adulthood.     

语言与数量认知关系的新认识

数量认知研究近年有长足发展。文章从新近提出的独立于语言的两个数量表征核心系统,语言与精确数量运算,语言与算术事实的储存,语言对儿童早期数概念发展的影响,语言与数量认知关系的最新脑科学证据,以及语言在数量认知模型中的角色等方面,介绍和评述了人类存在依赖和不依赖语言的两级数量能力的新认识。对于是否还存在其它不依赖语言的理解数量的系统,以及这些非语言数量表征系统的认知机制,文章认为有待进一步研究     

The somatotopy of speech: Phonation and articulation in the human motor cortex

A sizable literature on the neuroimaging of speech production has reliably shown activations in the orofacial region of the primary motor cortex. These activations have invariably been interpreted as reflecting “mouth” functioning and thus articulation. We used functional magnetic resonance imaging to compare an overt speech task with tongue movement, lip movement, and vowel phonation. The results showed that the strongest motor activation for speech was the somatotopic larynx area of the motor cortex, thus reflecting the significant contribution of phonation to speech production. In order to analyze further the phonatory component of speech, we performed a voxel-based meta-analysis of neuroimaging studies of syllable-singing (11 studies) and compared the results with a previously-published meta-analysis of oral reading (11 studies), showing again a strong overlap in the larynx motor area. Overall, these findings highlight the under-recognized presence of phonation in imaging studies of speech production, and support the role of the larynx motor cortex in mediating the “melodicity” of speech.     

Neocortical maturation during adolescence: change in neuronal soma dimension

During adolescence, cognitive abilities increase robustly. To search for possible related structural alterations of the cerebral cortex, we measured neuronal soma dimension (NSD = width times height), cortical thickness and neuronal densities in different types of neocortex in post-mortem brains of five 12-16 and five 17-24 year-olds (each 2F, 3M). Using a generalized mixed model analysis, mean normalized NSD comparing the age groups shows layer-specific change for layer 2 (p < .0001) and age-related differences between categorized type of cortex: primary/primary association cortex (BA 1, 3, 4, and 44) shows a generalized increase; higher-order regions (BA 9, 21, 39, and 45) also show increase in layers 2 and 5 but decrease in layers 3, 4, and 6 while limbic/orbital cortex (BA 23, 24, and 47) undergoes minor decrease (BA 1, 3, 4, and 44 vs. BA 9, 21, 39, and 45: p = .036 and BA 1, 3, 4, and 44 vs. BA 23, 24, and 47: p = .004). These data imply the operation of cortical layer- and type-specific processes of growth and regression adding new evidence that the human brain matures during adolescence not only functionally but also structurally.