Neurodevelopmental influences in the genesis and epigenesis of schizophrenia: An overview

The classical view of schizophrenia as a dementing disorder has recently been challenged by several findings pointing to a prenatal/perinatal origin of at least some of the brain abnormalities seen in these patients. This article reviews evidence from a number of different fields, including postmortem neuropathology, in vivo neuroimaging, developmental neuropsychology, and obstetric epidemiology in assessing the viability of a neurodevelopmental perspective of schizophrenia. Although the case for viewing schizophrenia as a neurodevelopmental condition is still circumstantial, and several gaps in this model remain, evidence from these diverse lines of inquiry converge to indicate at least a partial role of disturbances of brain development in the disorder's genesis and epigenesis.     

Spatial learning and goldfish telencephalon NMDA receptors

Recent results have demonstrated that the mammalian hippocampus and the dorso-lateral telencephalon of ray-finned fishes share functional similarities in relation to spatial memory systems. In the present study, we investigated whether the physiological mechanisms of this hippocampus-dependent spatial memory system were also similar in mammals and ray-finned fishes, and therefore possibly conserved through evolution in vertebrates. In Experiment 1, we studied the effects of the intracranial administration of the noncompetitive NMDA receptor antagonist MK-801 during the acquisition of a spatial task. The results indicated dose-dependent drug-induced impairment of spatial memory. Experiment 2 evaluated if the MK-801 produced disruption of retrieval of a learned spatial response. Data showed that the administration of MK-801 did not impair the retrieval of the information previously stored. The last experiment analyzed the involvement of the telencephalic NMDA receptors in a spatial and in a cue task. Results showed a clear impairment in spatial learning but not in cue learning when NMDA receptors were blocked. As a whole, these results indicate that physiological mechanisms of this hippocampus-dependent system could be a general feature in vertebrate, and therefore phylogenetically conserved.     

The nature of music from a biological perspective

Music, as language, is a universal human trait. Throughout human history and across all cultures, people have produced and enjoyed music. Despite its ubiquity, the musical capacity is rarely studied as a biological function. Music is typically viewed as a cultural invention. In this paper, the evidence bearing on the biological perspective of the musical capacity is reviewed. Related issues, such as domain-specificity, innateness, and brain localization, are addressed in an attempt to offer a unified conceptual basis for the study of music processing. This scheme should facilitate the study of the biological foundations of music by bringing together the fields of genetics, developmental and comparative research, neurosciences, and musicology.     

Qualia im Knotenpunkt zwischen Leib und Seele: „Argumentatives“ Dilemma in der gegenwärtigen Diskussion über die Subjektivität mentaler Zustände

Qualia in the node-point between mind and body: Dilemma of present discussion about the subjectivity of mental states. The present discussion about qualia shows a bewildering variety of different positions. We show implicit assumptions about brain, subject, and qualia of this complex discussion. By means of three assumptions we divide the discussion about qualia into three different positions (proposition, opposition, intermediate solutions). These positions and their exemplaric authors are briefly presented along the lines of the three assumptions. The next step shows how each position solves the dilemma which arises if one relates all three assumptions by eliminating at least one of the three assumptions. Finally, general problems in the discussion of qualia are shown by means of which the dilemma of the relation between brain, subject and qualia may be brought closer to a solution without eliminating one assumption.     

Using an AI creativity system to explore how aesthetic experiences are processed along the brain’s perceptual neural pathways

With the increased sophistication of AI techniques, the application of these systems has been expanding to ever newer fields. Increasingly, these systems are being used in modeling of human aesthetics and creativity, e.g. how humans create artworks and design products. Our lab has developed one such AI creativity deep learning system that can be used to create artworks in the form of images and videos. In this paper, we describe this system and its use in studying the human visual system and the formation of aesthetic experiences. Specifically, we show how time-based AI created media can be used to explore the nature of the dual-pathway neuro-architecture of the human visual system and how this relates to higher cognitive judgments such as aesthetic experiences that rely on these divergent information streams. We propose a theoretical framework for how the movement within percepts such as video clips, causes the engagement of reflexive attention and a subsequent focus on visual information that are primarily processed via the dorsal stream, thereby modulating aesthetic experiences that rely on information relayed via the ventral stream. We outline our recent study in support of our proposed framework, which serves as the first study that investigates the relationship between the two visual streams and aesthetic experiences.     

Prospective associations between physical fitness and executive function in adolescents: The UP&DOWN study

IntroductionThe objective of the present work is to investigate the prospective associations between physical fitness components (cardiorespiratory fitness, motor fitness, and muscular strength) and two domains of executive function (working memory and inhibitory control) in adolescents.MethodsA total of 422 Spanish adolescents (13.35 ± 1.54 years, at baseline) from the UP&DOWN study with assessments at baseline and at 2-year follow-up were included in the analysis. Physical fitness was assessed using the ALPHA Fitness Test Battery. Working memory was measured by the n-back task and inhibitory control by the go/no-go task. Relationships of physical fitness components with working memory and inhibitory control were examined using linear regression models, adjusted for confounders.ResultsHigher baseline levels of the three physical fitness components (cardiorespiratory fitness, motor fitness, and muscular strength) individually predicted better performance on the working memory (β_ranged, from .159 to .207; all p < .012) and inhibitory control (β_ranged, from 0.168 to 0.263; all p < .004) tasks at the 2-year follow-up. Muscular strength was the only component associated with inhibitory control independent of the other 2 physical fitness components (β = 0.266; p = .005).ConclusionsAll components of adolescents’ physical fitness at baseline were individually associated with better working memory and inhibitory control at 2-year follow-up. Specifically, our results revealed that muscular strength was the component showing the strongest association with executive function, and even the only fitness component associated with inhibitory control independent of the other fitness components. These findings may have important public health and educational implication, since promoting exercise programs that improve physical fitness, and particularly, muscular strength, may positively influence cognitive health.     

Cerebral cortical activity associated with non-experts’ most accurate motor performance

This study’s specific aim was to determine if non-experts’ most accurate motor performance is associated with verbal-analytic- and working memory-related cerebral cortical activity during motor preparation. To assess this, EEG was recorded from non-expert golfers executing putts; EEG spectral power and coherence were calculated for the epoch preceding putt execution; and spectral power and coherence for the five most accurate putts were contrasted with that for the five least accurate. Results revealed marked power in the theta frequency bandwidth at all cerebral cortical regions for the most accurate putts relative to the least accurate, and considerable power in the low-beta frequency bandwidth at the left temporal region for the most accurate compared to the least. As theta power is associated with working memory and low-beta power at the left temporal region with verbal analysis, results suggest non-experts’ most accurate motor performance is associated with verbal-analytic- and working memory-related cerebral cortical activity during motor preparation.     

Examining the link between adolescent brain development and risk taking from a social–developmental perspective (reprinted)

The adolescent age period is often characterized as a health paradox because it is a time of extensive increases in physical and mental capabilities, yet overall mortality/morbidity rates increase significantly from childhood to adolescence, often due to preventable causes such as risk taking. Asynchrony in developmental time courses between the affective/approach and cognitive control brain systems, as well as the ongoing maturation of neural connectivity are thought to lead to increased vulnerability for risk taking in adolescence. A critical analysis of the frequency of risk taking behaviors, as well as mortality and morbidity rates across the lifespan, however, challenges the hypothesis that the peak of risk taking occurs in middle adolescence when the asynchrony between the different developmental time courses of the affective/approach and cognitive control systems is the largest. In fact, the highest levels of risk taking behaviors, such as alcohol and drug use, often occur among emerging adults (e.g., university/college students), and highlight the role of the social context in predicting risk taking behavior. Moreover, risk taking is not always unregulated or impulsive. Future research should broaden the scope of risk taking to include risks that are relevant to older adults, such as risky financial investing, gambling, and marital infidelity. In addition, a lifespan perspective, with a focus on how associations between neural systems and behavior are moderated by context and trait-level characteristics, and which includes diverse samples (e.g., divorced individuals), will help to address some important limitations in the adolescent brain development and risk taking literature.     

教育神经科学:探究人类认知与学习的一条整合式途径

教育神经科学是第二代认知科学对人的具身认知进行认识深化的必然产物,也是不同层面研究以整合态势来研究教育情境中人的认知过程及其发展的当然结果。在认知神经科学与教育已有的良好沟通下,教育神经科学就是要通过教育学家、心理学家、神经科学家等的合力,借助多种技术(包括脑成像技术),多视角、多层面地分析人的心理活动,以求最终达到科学改进教育理论及其做法的目的。不可否认,本研究领域还存在一些问题;但这并不会就此阻止教育学、心理学、神经科学加快合作与融合的步伐。