fMRI of developmental stuttering: a pilot study

The purpose of this investigation was to explore the feasibility of fMRI in the study of developmental stuttering. Speech contrasts (loud versus silent reading) and language contrasts (reading of semantically meaningful text versus nonsense words) of six developmental stutterers and six nonstutterers were compared using a commercial 1 Tesla MR-Scanner (Siemens Expert). Results indicate that mapping cortical function in persons who stutter is indeed feasible, even with a 1TMR-system. Compared to normals the stutterers seemed to employ different and particularly less differentiated auditory and motor feedback strategies in speech. They apparently rely on auditory processing and on cerebellar contribution as much during silent reading as during reading aloud. Moreover, they showed a greater involvement of the right hemisphere in language processing, activating not only the typical language areas on the left but also and with equal magnitude the right side homologues of these areas. In spite of the promising results, at present several practical problems such as possible movement artifacts and possible masking through scanner noise still hamper a more straightforward use of fMRI in the study of developmental stuttering.     

Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models

Developmental differences in hypothalamic–pituitary–adrenal (HPA) axis responsiveness to stressors and ongoing development of glucocorticoid-sensitive brain regions in adolescence suggest that similar to the neonatal period of ontogeny, adolescence may also be a sensitive period for programming effects of stressors on the central nervous system. Although research on this period of life is scarce compared to early life and adulthood, the available research indicates that effects of stress exposure during adolescence differ from, and may be longer-lasting than, effects of the same stress exposure in adulthood. Research progress in animal models in this field is reviewed including HPA function and the enduring effects of stress exposures in adolescence on sensitivity to drugs of abuse, learning and memory, and emotional behaviour in adulthood. The effects of adolescent stress depend on a number of factors, including the age, gender, the duration of stress exposure, the type of stressor, and the time between stress exposure and testing.     

Mapping gray matter development: Implications for typical development and vulnerability to psychopathology

Recent studies with brain magnetic resonance imaging (MRI) have scanned large numbers of children and adolescents repeatedly over time, as their brains develop, tracking volumetric changes in gray and white matter in remarkable detail. Focusing on gray matter changes specifically, here we explain how earlier studies using lobar volumes of specific anatomical regions showed how different lobes of the brain matured at different rates. With the advent of more sophisticated brain mapping methods, it became possible to chart the dynamic trajectory of cortical maturation using detailed 3D and 4D (dynamic) models, showing spreading waves of changes evolving through the cortex. This led to a variety of time-lapse films revealing characteristic deviations from normal development in schizophrenia, bipolar illness, and even in siblings at genetic risk for these disorders. We describe how these methods have helped clarify how cortical development relates to cognitive performance, functional recovery or decline in illness, and ongoing myelination processes. These time-lapse maps have also been used to study effects of genotype and medication on cortical maturation, presenting a powerful framework to study factors that influence the developing brain.     

CT故障停机时放射科危机管理的应用研究

放射科应用危机管理理论,在CT故障停机时,启动危机处理方案:用MRI替代检查,配以危机处理工作流程,MRI加班不停机和一小时内出报告等措施,保障了患者影像诊疗的持续性,使"以患者为中心"得以拓展和落实,为医院带来了良好的品牌效益、服务效益和技术效益。     

The effects of musical practice on structural plasticity: The dynamics of grey matter changes

Intensive training and the acquisition of expertise are known to bring about structural changes in the brain. Musical training is a particularly interesting model. Previous studies have reported structural brain modifications in the auditory, motor and visuospatial areas of musicians compared with nonmusicians. The main goal of the present study was to go one step further, by exploring the dynamic of those structural brain changes related to musical experience. To this end, we conducted a regression study on 44 nonmusicians and amateur musicians with 0–26 years of musical practice of a variety instruments. We sought first to highlight brain areas that increased with the duration of practice and secondly distinguish (thanks to an ANOVA analysis) brain areas that undergo grey matter changes after only limited years of musical practice from those that require longer practice before they exhibit changes. Results revealed that musical training results a greater grey matter volumes in different brain areas for musicians. Changes appear gradually in the left hippocampus and right middle and superior frontal regions, but later also include the right insula and supplementary motor area and left superior temporal, and posterior cingulate areas. Given that all participants had the same age and that we controlled for age and education level, these results cannot be ascribed to normal brain maturation. Instead, they support the notion that musical training could induce dynamic structural changes.     

APOLOGIA PRO SCRIPTURA SUA, OR MAYBE WE GOT IT RIGHT AFTER ALL

Abstract. A summary of the progress of biogenetic structuralism as an approach to the social and behavioral sciences is presented, from the publication of Biogenetic Structuralism in 1974 to the present. The difficulty that many scholars have found integrating neuroan-thropology and comparative ethology into an understanding of cultural, and particularly of religious, phenomena over the past almost two decades is considered. More specifically, the articles of James Ashbrook and Mary Lynn Dell published in the same June 1993 issue of Zygon as this article are analyzed and responded to. These authors critique Eugene d'Aquili's work of integrating neuropsychology and religious experience primarily by analyzing Brain, Symbol & Experience , which d'Aquili co-authored with Charles Laughlin, Jr., and John McManus, H. Rodney Holmes's article in the same issue of Zygon analyzes the whole corpus of d'Aquili's religion and science work as it appeared over the years in the pages of Zygon and in other articles and books as well as in Brain, Symbol & Experience. This critique is likewise carefully considered and responded to. Finally a proposed trajectory of d'Aquili's (and Andrew Newberg's) future work in their ongoing project integrating neuropsychology and religious experience is elaborated. This involves, not only expansion of their general theoretical approach, but also empirical testing of hypotheses relating brain function to religious experience using PET scanning and some newer MRI visualization techniques.