Posterior superior temporal cortex connectivity is related to social communication in toddlers

The second year of life is a time when social communication skills typically develop, but this growth may be slower in toddlers with language delay. In the current study, we examined how brain functional connectivity is related to social communication abilities in a sample of 12-24 month-old toddlers including those with typical development (TD) and those with language delays (LD). We used an a-priori, seed-based approach to identify regions forming a functional network with the left posterior superior temporal cortex (LpSTC), a region associated with language and social communication in older children and adults. Social communication and language abilities were assessed using the Communication and Symbolic Behavior Scales (CSBS) and Mullen Scales of Early Learning. We found a significant association between concurrent CSBS scores and functional connectivity between the LpSTC and the right posterior superior temporal cortex (RpSTC), with greater connectivity between these regions associated with better social communication abilities. However, functional connectivity was not related to rate of change or language outcomes at 36 months of age. These data suggest an early marker of low communication abilities may be decreased connectivity between the left and right pSTC. Future longitudinal studies should test whether this neurobiological feature is predictive of later social or communication impairments.     

Predictions of X-linked inheritance for human characteristics

The conclusion reached by H. Thomas and W. Jamison (Developmental Review, 1981, 1, 274–283) that an observed sex-related difference in water-level task performance is due to an X-linked major gene raises the question of whether available data would be consistent with X-linkage predictions other than the one tested. Several predictions of X-linked inheritance for human characteristics are presented and discussed. It was concluded that although water-level task performance may involve a heritable component, the available data from seven independent studies reviewed by Thomas and Jamison are insufficient for determining the specific mode of genetic transmission.     

精神、意识到底有无实体

精神、意识有无实体历来是一个有争议的问题。神经科学家从“心网”与“脑网”的关系出发,在这个问题上形成了片面的认识。由于精神、意识依赖于人脑,因而他们就把精神、意识与实体的关系等同于“心网”与“脑网”的关系。我们的基本观点是：首先,精神、意识与实体之间的关系实际上是哲学上的主观与客观的关系;第二,意识作为哲学范畴还有人类意识与个体意识之分,并认为“三个世界”的理论能够较完满地解决这一争端。要揭示意识的本质不能仅仅依赖神经科学家。     

Sex differences in brain activity, personality and intelligence: a test of arousability theory

This report describes empirical tests of the theory that females have higher levels of behavioural and cerebral arousal than males and that these differences cause higher neuroticism scores in females, as well as lower female psychoticism scores and lower scores for females on the Gsar factor of intelligence. Data were obtained from 76 subjects, with equal numbers of males and females and with all adult ages represented. EEG responses to auditory stimulation were quantified in terms of the ‘amplitude, ‘rate of change of amplitude and ‘sweep variability factors obtained from a principal components analysis (PCA). Gf, Gc and Gsar intelligence scores were obtained from a PCA of sub-tests from the Wechsler Adult Intelligence Scale plus Ravens Advanced Progressive Matrices test. Personality differences were evaluated using the Neuroticism and Psychoticism scales of the Eysenck Personality Questionnaire (EPQ). Bivariate hypotheses relating sex to the arousal, intelligence and personality variables were confirmed. A PCA demonstrated that sex, neuroticism, Gsar, wakefulness and high frequency EEG activity all have high loadings on a common factor. These results are consistent with expectations generated by the cerebral arousability theory of personality and intelligence.     

The effects of encoding distinctiveness on retrieval variability in children and adults

To what extent are developmental differences in encoding distinctiveness responsible for differences in retrieval variability? This study examined this question by comparing the effects of different kinds of encoding distinctiveness on the ability of children and adults to reinstate the input environment at retrieval. The critical manipulations involved the use of semantic orienting questions at both encoding and retrieval. Second and fourth (Experiment 1) or fifth (Experiment 2) graders and college adults were given moderately associated word pairs (Knife-Axe) at input. Encoding was free or constrained at input and retrieval. The retrieval questions biased the Same interpretation of the cue as at input (weapon), a uniquely Different interpretation (utensil), or an inappropriate Negative interpretation. Encoding distinctiveness was varied by crossing these manipulations with either picture or word input (Experiment 1) or general or distinctive orienting questions (Experiment 2). The results suggested that encoding distinctiveness and retrieval variability contribute independently to developmental differences in recall.     

Behind the wheels with autism and ADHD: Brain networks involved in driving hazard detection

Driving is a cognitively challenging task, and many individuals with autism spectrum disorder (ASD) or with attention-deficit/hyperactivity disorder (ADHD) struggle to drive safely and effectively. Previous evidence suggests that core neuropsychological deficits in executive functioning (EF) and theory of mind (ToM) may impact driving in ASD and ADHD. This functional magnetic resonance imaging (fMRI) study compares the brain mechanisms underlying ToM and EF during a hazard perception driving task. Forty-six licensed drivers (14 ASD, 17 ADHD, 15 typically developing (TD)), ages 16–27 years, viewed a driving scenario in the MRI scanner and were instructed to respond to driving hazards that were either “social” (contained a human component such as a pedestrian) or “nonsocial” (physical objects such as a barrel). All groups of participants recruited regions part of the “social brain” (anterior insula, angular gyrus, right middle occipital gyrus, right cuneus/precuneus, and right inferior frontal gyrus) when processing social hazards, and regions associated with motor planning and object recognition (postcentral gyrus, precentral gyrus, and supplementary motor area) when processing nonsocial hazards. While there were no group differences in brain activation during the driving task, years licensed was predictive of greater prefrontal and temporal activation to social hazards in all participants. Findings of the current study suggest that high-functioning ASD and ADHD licensed drivers may be utilizing similar cognitive resources as TD controls for decisions related to driving-related hazard detection.     

Massive redeployment,exaptation, and the functional integration of cognitive operations

The massive redeployment hypothesis (MRH) is a theory about the functional topography of the human brain, offering a middle course between strict localization on the one hand, and holism on the other. Central to MRH is the claim that cognitive evolution proceeded in a way analogous to component reuse in software engineering, whereby existing components—originally developed to serve some specific purpose—were used for new purposes and combined to support new capacities, without disrupting their participation in existing programs. If the evolution of cognition was indeed driven by such exaptation, then we should be able to make some specific empirical predictions regarding the resulting functional topography of the brain. This essay discusses three such predictions, and some of the evidence supporting them. Then, using this account as a background, the essay considers the implications of these findings for an account of the functional integration of cognitive operations. For instance, MRH suggests that in order to determine the functional role of a given brain area it is necessary to consider its participation across multiple task categories, and not just focus on one, as has been the typical practice in cognitive neuroscience. This change of methodology will motivate (even perhaps necessitate) the development of a new, domain-neutral vocabulary for characterizing the contribution of individual brain areas to larger functional complexes, and direct particular attention to the question of how these various area roles are integrated and coordinated to result in the observed cognitive effect. Finally, the details of the mix of cognitive functions a given area supports should tell us something interesting not just about the likely computational role of that area, but about the nature of and relations between the cognitive functions themselves. For instance, growing evidence of the role of “motor” areas like M1, SMA and PMC in language processing, and of “language” areas like Broca’s area in motor control, offers the possibility for significantly reconceptualizing the nature both of language and of motor control.     

Differences in numeric,verbal, and spatial reasoning between engineering and literature students through a neurocognitive lens

This study used electroencephalography to investigate the brain activations of college students of various disciplines when they responded to questions in numeric, verbal, and spatial reasoning tasks. In total, 15 engineering students and 15 literature students were recruited in this experiment and were asked to respond to 12 intelligence test questions. The results were as follows: (i) the participants’ brain activations increased in the frontoparietal network during the numeric reasoning task, and the spectral power in the right anterior temporal cortex was generally higher in the literature students than in the engineering students. (ii) Activations of the language network were observed during the verbal reasoning task, and the spectral power in the right-biased posterior frontal cortex was generally higher in the literature students than in the engineering students; by contrast, the spectral power in the left lateral frontal cortex was generally higher in the engineering students than in the literature students. (iii) The participants’ brain activations increased in the spatial processing network during the spatial reasoning task, and the spectral power in the right posterior temporal cortex was generally higher in the literature students than in the engineering students.     

创造性思维的脑机制

创造性思维是创造性的核心。近年来,脑电和脑成像技术的发展为研究创造性思维的神经基础提供了有力的技术支持,对创造性思维的脑机制研究取得了较大进展。创造性思维的脑机制研究主要包括顿悟的脑机制、发散性思维的脑机制、远距离联想的脑机制、言语创造性和图画创造性的对比的脑机制研究。研究结果显示创造性思维需要多个脑区的参与,因不同的认知任务其关键脑区而有所不同。对创造性思维的脑机制研究进行了总结,对这些研究可能存在创造性思维究竟应该定义为“领域一般的”还是“领域特殊的”的解释进行了讨论,并指出了研究中可能存在的基线任务设置问题和未来研究中需要在研究手段、研究设计、研究领域等方面加以改进的建议     

Putative sex differences in verbal abilities and language cortex: a critical review

This review brings together evidence from a diverse field of methods for investigating sex differences in language processing. Differences are found in certain language-related deficits, such as stuttering, dyslexia, autism and schizophrenia. Common to these is that language problems may follow from, rather than cause the deficit. Large studies have been conducted on sex differences in verbal abilities within the normal population, and a careful reading of the results suggests that differences in language proficiency do not exist. Early differences in language acquisition show a slight advantage for girls, but this gradually disappears. A difference in language lateralization of brain structure and function in adults has also been suggested, perhaps following size differences in the corpus callosum. Neither of these claims is substantiated by evidence. In addition, overall results from studies on regional grey matter distribution using voxel-based morphometry, indicate no consistent differences between males and females in language-related cortical regions. Language function in Wada tests, aphasia, and in normal ageing also fails to show sex differentiation.