血清CHO、D-二聚体、FDP与Child-Pugh分级的关系研究

为了探讨血清胆固醇（CHO）、D-二聚体、纤维蛋白降解产物（FDP）与肝硬化Child-Pugh分级的关系,选取73例肝硬化患者按Child-pugh评分分为A、B、C级,与30例健康对照组比较,肝硬化组CHO显著降低,D-二聚体和FDP显著升高,且A级与B级、B级与C级之间均有差异。因此,联合检测肝硬化患者CHO、D-二聚体、FDP含量,对肝脏受损的严重程度、肝病的疗效观察及预后具有重要的临床意义。     

Resilience in Scientific Research: Understanding How Natural Product Research Rebounded in an Adverse Situation

The recent declining rate in the discovery of new drugs has made natural product (NP) research—the traditional method of using living organisms to acquire drug candidates—regain its importance, despite the fact that it was once regarded as an obsolete method in the face of the exalted expectations about emerging new approaches since the 1990s. The concept of ‘resilience’ in scientific research provides a clue for understanding the dynamism of this rebound in research. Four elements may be highlighted in the context of microbial NP research in Japan: first, ‘institutional precondition’ is essential in the sense that the research must be rooted in an institutional complex involving academia, drug companies, and national policies. Second, the dual nature of the ‘attack from rival innovations’ including semiotic labeling and technical advances is examined. Third, four approaches to NP research are observed as responses to such challenges: (1) reevaluating the naturalness of NPs; (2) adopting various technical elements from their rivals; (3) shifting the emphasis from the practical pursuit of drug candidates to biological research using bioprobes; and (4) examining the uneven degree of resilience between academia and industry. Fourth and finally, NPs are viewed as an icon of cultural practice. This view may eventually open the door to questions about the meaning of ‘tradition’ in the context of general contemporary scientific research.     

努力程度对消费者购买意愿的影响

在日常生活中, 消费者经常面临着各种各样的自我控制问题。当消费者有合适的理由时, 他们会放松自我控制。基于此, 本文经由三个实验探查了消费者努力程度对消费者购买意愿的影响。其中, 实验一和实验二通过操纵被试的相对努力程度, 发现努力会提高人们对于产品的购买意愿, 并且证明负罪感的变化是导致这一影响的内在原因。实验三通过改变产品品类, 证明相对于实用品, 努力对于人们对享乐品的购买意愿的影响更大。     

A mechanism model of the effect of hedonic product consumption on well‐being

In response to recent calls for research into activities that may increase happiness, this study uses longitudinal data to investigate changes in within-subject, instead of between-subject, well-being. In the context of hedonic product consumption, this study reveals a mechanism by which consumption influences well-being through the mediating effect of satisfaction with associated life domains. Four years of data from a large national panel survey show that consuming hedonic products has indirect effects on well-being, by improving consumers' satisfaction within relevant life domains. High hedonic consumption improves satisfaction with relevant life domains, primarily through more frequent consumption of low-cost hedonic products rather than less frequent consumption of high-cost hedonic products.     

L’accès aux médicaments : quelles contributions des règles sur les brevets de l’Accord de partenariat transpacifique global et progressiste ?

Enhanced protection for patents in free trade agreements would undermine access to medicines and show difficulties for developing countries with respect to public health issue. In the context of the Comprehensive and Progressive Trans-Pacific Partnership Agreement, however, after the withdrawal of the United States, the legal regime applicable to patents seems less rigid and, therefore, more favorable to access to medicines. This results, on the one hand, from certain flexibilities contained in this agreement itself; and on the other hand, the suspension of some material and procedural obligations. This article aims to analyze these two sides to justify the contribution of this agreement to ensure access to medicines.     

Can designing and selling low-quality products be ethical?

Whereas previous studies have criticized low-quality products for inadequate safety, this paper considers only safe products, and it examines the ethics of designing and selling low-quality products. Product quality is defined as suitability to a general purpose. The duty that companies owe to consumers is summarized in the Consumer-Oriented Process principle: “to place an increase in the consumer’s quality of life as the primary goal for producing products.” This principle is applied in analyzing the primary ethical justifications for low-quality products: availability and applicability. Finally, a low-quality product should be designed afresh, not by altering an existing high-quality product. Supported by the National Science Foundation under Grant CCR-9315696. The views, opinions, and conclusions of this paper are not necessarily those of the University of Illinois or the National Science Foundation. A preliminary version of this paper was presented at the Fifth Annual Meeting of the Association for Practical and Professional Ethics, St. Louis, Mo., February 29 to March 2, 1996. Willem Bakker is an undergraduate at the University of Illinois at Urbana-Champaign. He is majoring in computer engineering and philosophy. Michael Loui is professor of electrical and computer engineering and associate dean of the Graduate College at the University of Illinois at Urbana-Champaign. From 1990 to 1991, he served at the National Science Foundation in Washington, D.C. His scholarly interests include computational complexity theory, theory of parallel and distributed computation, faulttolerant software, and professional ethics.     

The Logic of Quantum Measurements in terms of Conditional Events

This paper shows that the non-Boolean logic of quantum measurementsis more naturally represented by a relatively new 4-operationsystem of Boolean fractions—conditional events—thanby the standard representation using Hilbert Space. After therequirements of quantum mechanics and the properties of conditionalevent algebra are introduced, the quantum concepts of orthogonality,completeness, simultaneous verifiability, logical operations,and deductions are expressed in terms of conditional eventsthereby demonstrating the adequacy and efficacy of this formulation.Since conditional event algebra is nearly Boolean and consistsmerely of ordered pairs of standard events or propositions,quantum events and the so-called "superpositions" of statesneed not be mysterious, and are here fully explicated. Conditionalevent algebra nicely explains these non-standard "superpositions"of quantum states as conjunctions or disjunctions of conditionalevents, Boolean fractions, but does not address the so-called"entanglement phenomena" of quantum mechanics, which remainphysically mysterious. Nevertheless, separating the latter phenomenafrom superposition issues adds clarity to the interpretationof quantum entanglement, the phenomenon of influence propagatedat faster than light speeds. With such treacherous possibilitiespresent in all quantum situations, an observer has every reasonto be completely explicit about the environmental–instrumentalconfiguration, the conditions present when attempting quantummeasurements. Conditional event algebra allows such explicationwithout the physical and algebraic remoteness of Hilbert space.     

How context shapes category inferences and attribute preference for new ambiguous products

Extant research suggests that when marketers introduce products with functions that span multiple categories, consumers tend to generate beliefs in line with only a single category. This has been regarded as a major marketing challenge because it leads consumers to ignore key attributes from the product's supplementary category. Contrary to this prediction, the authors find that because consumers tend to classify new hybrid products by contrasting them against the competitive context, attributes from the supplementary category become more salient and thus contribute greater utility in choice. The authors pit the strength of this effect against several of the most dominant and favored category cues. The results confirm that classification inferences and attribute preference for new hybrid products are highly contextual, and as such, single category inferences need not translate directly into attribute preference.     

Abstractness and Messages Describing Consequences Promote Healthier Behavioral Intentions

Many health-risk behaviors present a self-control conflict in which the short-term outcomes of an action conflict with its long-term consequences. Across three studies, we find that an abstract construal level leads people to focus on long-term rather than short-term consequences when both are described in a message (vs. no message). Studies 1 and 2 explore this hypothesis through a risk behavior (snacking on sugary products), and Study 3 does the same through a health behavior (physical exercise). In Study 1, the Behavioral Identification Form scale is used to measure the construal level as a personal disposition; Studies 2 and 3 use a priming task designed by Freitas, Gollwitzer, and Trope to manipulate the construal level. All these studies show that, under an abstract mindset, people who have read a mixed-outcome message (vs. no message) tend to base their behavioral plans on long-term outcomes. Individually or in small groups (e.g. school class, therapy groups) health messages can be presented along with protocols to change construal level and thus, promote healthier intentions.