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351.
依据错误驱动的学习理论,行为预期结果与实际结果之间的不匹配即预期错误(Predictionerror,PE)是学习产生的驱动因素。作为显著性信息中的一种,预期错误和物理显著性、惊讶、新异性等存在信息加工阶段的不同,与记忆更新的关系也有差异。近年来,记忆再巩固干预范式(reconsolidation interference)被证明可用于人类条件性恐惧记忆的更新,其中记忆提取激活阶段所包含的预期错误起到了引发记忆“去稳定”、开启记忆再巩固的关键作用。在促进恐惧记忆更新的行为机制上,PE被认为是记忆去稳定的必要非充分条件。记忆提取必须包含适量的PE,但其引发的是记忆去稳定、消退还是中间状态,还需结合记忆本身性质确定。在促进恐惧记忆更新的神经机制上,杏仁核、导水管周围灰质(PAG)、海马均在PE探测和计算过程中具有重要作用;前额叶皮层(PFC)及其亚区在PE开启记忆再巩固过程中扮演了重要角色。上述过程又受到神经系统中特定神经递质的重要调节,尤其是多巴胺能和谷氨酸能。未来研究应进一步探索基于PE计算模型的量化研究,整合PE与其他边界条件的交互作用,考察不同类型显著性在记忆再巩固中的作用等;并亟...  相似文献   
352.
李培培  张丽丽  韦美  李敏 《心理学报》2011,43(5):544-552
探讨条件性恐惧大鼠内侧前额叶皮层边缘下区(IL区)Cdk5激酶活性、凋亡因子caspase-3表达和突触结构的变化。采用声音结合足底电击的方法对大鼠建立条件性恐惧模型后, 在不同时间点测定IL区Cdk5激活剂P35和P25的蛋白表达水平、Cdk5激酶活性、caspase-3的阳性细胞数, 并观察突触结构的变化。结果发现, 大鼠在条件性恐惧建立后第2、4和8天, IL区的P25蛋白表达和Cdk5激酶活性均明显高于正常; caspase-3的免疫反应阳性细胞数在3个时间点也均多于正常; 透射电镜下观察到:在恐惧建立后的第8天, IL区突触的突触后致密物质(PSD)厚度变薄, 在恐惧建立后第22天突触数密度减少、PSD厚度仍小于正常。推测条件性恐惧的建立, 使大鼠IL区的P25水平和Cdk5活性高于正常, 引起IL区的突触结构发生改变, 导致大鼠的恐惧反应持续存在。  相似文献   
353.
This study investigated links between three forms of perfectionism and beliefs associated with fear of failure (FF). College students (N = 372) enrolled in physical activity classes completed the Multidimensional Perfectionism Scale and Performance Failure Appraisal Inventory in a single session. After controlling for other forms of perfectionism, only socially prescribed perfectionism (SPP) was strongly associated with beliefs that failure led to aversive interpersonal consequences (i.e., important others losing interest, upsetting important others). Other-oriented perfectionism (OOP) exhibited a weak negative relation with beliefs that failure would lead to devaluation of one’s self-estimate; individuals who held the highest standards for others’ behavior had the weakest beliefs that failure would lead to them devaluing their self-estimate. Self-oriented perfectionism (SOP) was not associated with any beliefs that failure led to aversive consequences; however, when SOP and OOP were simultaneously elevated, they contributed positively to fears of experiencing shame and embarrassment (above and beyond main effects of SPP). Collectively these findings indicated that FF was not ubiquitous with all forms of perfectionism because the specific beliefs about the consequences of failure that underlie different forms of perfectionism varied tremendously. This research was supported in part by a grant from the College of Health & Human Development, The Pennsylvania State University.  相似文献   
354.
This paper examines the clinical features, symptom severity, diagnostic profile, and help-seeking behaviour of a media-recruited sample of driving-fearful women. Results support previous findings of the primary foci of fear as motor vehicle accidents as well as specific driving situations and conditions. Consistent with prior research, there was difficulty relating the foci of fear to current diagnostic concepts. Social concerns were identified as having a role in driving fear for some individuals. Fearful participants exhibited high levels of fear and symptom severity according to various diagnostic and self-report measures, although most reported that they would be unlikely to seek professional psychological help or driving instruction. Assessment of cognitions indicated a range of errors likely to maintain anxiety and fear reactions that would be a target of treatment. There were no group differences in number of major recent accidents, although fearful drivers learnt to drive later than controls, suggesting early fearfulness.
Joanne E. TaylorEmail:
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355.
The present study explores driving skills in a group of 50 media-recruited driving-fearful and 50 control drivers, all of whom were women. Participants completed an on-road practical driving assessment with a professional driving instructor. Diagnostic as well as pre-post self-report and instructor driving assessments were conducted. Fearful drivers made more errors on the driving assessment than controls. However, the pattern of errors was identical for both groups, indicating that fear and anxiety may be associated with the number rather than the type of driving errors made. These differences remained when factors such as driving history, current driving frequency, and diagnosis were controlled using case selection. More research is needed to replicate the findings in more diverse samples. Additional work should also aim to clarify the specific role of driving skills in driving fear, which will facilitate treatment planning for exposure-based treatments and help identify cases where driving skills assessment may be appropriate.  相似文献   
356.
睡眠问题可能会诱发恐惧相关情绪障碍(焦虑、创伤性应激障碍、恐怖症等),研究睡眠影响恐惧学习的认知神经机制,有助于增强对恐惧相关情绪障碍的预测、诊断和治疗。以往研究表明睡眠剥夺影响恐惧习得和消退主要是通过抑制vmPFC活动,阻碍其与杏仁核的功能连接,从而导致恐惧习得增强或是消退学习受损。进一步研究发现睡眠不同阶段对恐惧学习相关脑区有独特的影响:剥夺(缺乏)快速眼动睡眠会抑制vmPFC活动、增强杏仁核、海马激活,导致恐惧习得增强,消退学习受损,此外边缘皮层的功能连接减少破坏了记忆巩固(恐惧记忆和消退记忆);而慢波睡眠主要与海马变化有关,慢波睡眠期间进行目标记忆重激活可促进恐惧消退学习。未来研究需要增加睡眠影响恐惧泛化的神经机制研究、及昼夜节律中断对恐惧消退的影响,以及关注动物睡眠研究向人类睡眠研究转化中存在的问题。  相似文献   
357.
Recent conceptualisations of anxiety posit that equivocal findings related to the time-course of disengaging from threat-relevant stimuli may be attributable to individual differences in associative and rule-based processing. The current study was designed to test the hypothesis that strength of spider-fear associations would indirectly predict reported spider fear via impaired disengagement. One hundred and thirty-one undergraduate volunteer participants completed the Go/No-go Association Task, a visual search task, and self-report spider fear questionnaires. Stronger spider-fear associations were associated with reduced disengagement accuracy, whereas higher levels of reported spider fear were related to faster engagement with and disengagement from spiders. Bootstrapping multiple mediation analyses demonstrated that stronger-spider fear associations evidenced an indirect relationship with reported spider fear via reduced disengagement accuracy, highlighting the importance of fine-grained analyses of different aspects of cognitive bias. Results are discussed in terms of cognitive models of anxiety.  相似文献   
358.
Nachträglichkeit provides the memory, not the event, with traumatic signifi cance and signifi es a circular complementarity of both directions of time. Conceived by Freud as early as 1895 in the Project for a scientifi c psychology, the concept remains in his work without offi cial status but through its character of biphasic development and latency indispensable for understanding temporal connections and psychic causality. As an implicit principle it is linked with the postponement and biphasic onset of sexual life … and retains its sometimes hidden importance until the late Moses study. Temporarily virtually forgotten, it was recalled to memory by Lacan in 1953. Translations into French as après‐coup and into English as ‘deferred action’ emphasized the two vectors (retroactivity and after‐effect) separately which are united in the substantive form coined by Freud. Unnoticed, it played a part in many aspects of clinical practice, especially in Winnicott's Fear of breakdown and the subsequent (nachträglich) working through of unconscious infantile and transgenerational confl icts. The author uses a clinical illustration to elucidate the belated understanding of the striving for non‐existence in Winnicott's sense. Wolfgang Loch extended Freud's concept of Nachträglichkeit in a constructivist way, advocating an art of interpretation as an innovative enterprise through which connections are not only unmasked but also created, constituted by subsequent (nachträglich) reinterpretation of a subjective past. Very briefl y the author refers to the interdisciplinary reception of the concept of Nachträglichkeit, especially in cultural studies.  相似文献   
359.
Recent evidence suggests that drug-induced conditioned taste avoidance may be mediated by conditioned fear (e.g., Parker, 2003). The experiments reported here evaluated the effect of exposure to a drug-paired flavor on open arm exploration in an elevated plus maze (EPM), a measure of fear. When rats were tested on a familiar (trial 2) EPM, but not on a novel (trial 1) EPM, prior exposure to a lithium-paired saccharin solution enhanced open arm activity relative to saline-paired saccharin. On the other hand, when rats were exposed to lithium-paired saccharin during plus maze exposure, they displayed suppressed open arm activity relative to unpaired controls when tested in a familiar maze. The pattern of results was specific to the conditional affective properties of the taste, because exposure to unconditional sickness produced by administration of lithium, and unconditionally unpalatable quinine solution did not produce this pattern. These results were interpreted in terms of the opponent process model of motivation; that is, exposure to a lithium-paired flavor elicits conditioned fear which is immediately followed by conditioned relief when the exposure is terminated. On the other hand, exposure to an amphetamine-paired flavor either before or during EPM testing enhanced open arm exploration. Since the strength of taste avoidance did not differ among amphetamine and lithium conditioned rats, these results provide further evidence that the nature of a saccharin-lithium association differs from that of a saccharin-amphetamine association.  相似文献   
360.
Children and adolescents who exhibit a callous interpersonal style seem to be at risk for developing severe forms of violent behavior. Theoretical models suggest that children with low levels of temperamental fearfulness may be at increased risk for developing callous traits because they are relatively unaffected by punishment. This study examines hypotheses about the callousness pathway to severe violent delinquency in a cross‐sectional sample of 169 (97=males, 72=females) adjudicated adolescents. Structural equation modeling is used to test mediation models regarding the relation between temperamental fear, punishment concern, callousness, and severe violent delinquency. The findings of the study indicate that the relation between low levels of temperamental fear and increased callousness is mediated by a lack of concern about being punished for aggressive acts. Although low levels of fear and punishment concern were both related to increased levels of severe violent delinquency, increased levels of callousness mediated these relations. All findings remained significant after controlling for the potential confounds of gender, race, and social desirability. The results provide a heuristic for understanding the callousness pathway to severe violent behavior in youth. However, longitudinal investigations replicating these results are necessary before firm conclusions can be drawn. Aggr. Behav. 32:590–598, 2006. © 2006 Wiley‐Liss, Inc.  相似文献   
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