The neural pathways mediating quiet-biting attack behavior from the hypothalamus in the cat: A functional autoradiographic study

Electrical stimulation of the region of the lateral hypothalamus produced a consistent form of quiet-biting attack behavior in cats. In one series of experiments, cats, implanted with electrodes from which attack had been elicited, were anesthetized and then were injected with a bolus of ¹⁴C-2-deoxyglucose at the same time as electrical stimulation was delivered through the attack electrodes. Brains prepared for X-ray autoradiography revealed that lateral hypothalamic stimulation activated the classical medial forebrain bundle pathway supplying the septal region, diagonal band, lateral preoptic area, and ventral tegmental region. Stimulation of quiet-attack sites in perifornical hypothalamus resulted in the activation of a much more extensive projection system which included the central and lateral tegmental fields of the midbrain and pons, and central gray region, as well as the structures described above. In a second series of experiments, ³H-leucine was placed into the region of the electrode tip from which attack was elicited in order to identify more precisely the pathways arising from that site. In general, tritiated amino acid radioautography replicated the ¹⁴C-2-deoxyglucose findings. In addition, the amino acid radioautographic data revealed the presence of extensive projections from perifornical hypothalamus to such pontine structures as the nucleus locus coeruleus, motor nucleus of NV , and the lateral pontine tegmental field. The functional connections between the lateral hypothalamic “attack region” and lateral preoptic zone were also confirmed by electrophysiological methods.     

急性应激损害对威胁刺激的注意解除

急性应激会增强个体对威胁刺激的注意偏向, 但急性应激是增强了对威胁刺激的注意定向还是损害了对威胁刺激的注意解除还不清楚。本研究采用社会评估冷压任务和点探测任务, 结合事件相关电位技术, 考察急性应激对威胁刺激注意偏向影响的认知机制。在进行社会评估冷压任务后, 应激组个体的状态焦虑和皮质醇浓度显著升高。在注意偏向中, 应激组对威胁刺激的注意解除比控制组更慢, 应激组和控制组在对威胁刺激的注意定向上无显著差异。ERP结果上, 威胁刺激诱发应激组比控制组产生了更负的SPCN, 在N2pc上没有显著差异。应激组和控制组皮质醇增量的差异和N2pc、SPCN的组间差异均有显著正相关。这些结果说明, 急性应激增强对威胁刺激的注意偏向是因为其损害个体对威胁刺激的注意解除, 这可能是因为急性应激损害了与注意解除相关的额-顶网络的功能所致。     

语言熟练度对Stroop效应的影响——不平衡双语者的任务态fMRI研究

目的:探讨语言熟练度对Stroop效应的影响及其背后的脑机制。材料与方法:17位被试参与本研究。被试母语为汉语,第二语言为英语。在被试完成中英文的stroop色字的任务过程中对被试进行fMRI扫描。结果:在色字相一致的条件下,中文任务与英文任务相比,双侧背侧枕叶及右侧背外侧前额叶有更强的激活; 反向比较,双侧腹侧枕叶有更强的激活。在色字不一致的条件下,中文任务与英文任务相比,双侧背外侧前额叶、右侧枕下回有更强的激活; 反向比较,并无显著激活的脑区。此外,中文Stroop效应引起左侧额下回显著的激活。英文Stroop效应中,左侧额下回无显著激活。结论:结合前人研究,我们得出,语言熟练度影响了对注意控制有重要作用的背外侧前额叶以及与反应抑制有关的左侧额下回在Stroop任务中的参与程度,进而影响了Stroop任务的表现     

Human factors evaluation of an in-vehicle active traffic and demand management (ATDM) system

This research study focused on the evaluation of an emulated in-vehicle Active Traffic and Demand Management (ATDM) system on Interstate 66 in Northern Virginia. Traditional ATDM systems rely on infrastructure-mounted variable message signs (VMS) to provide information (speed limits, lane availability, etc.) to the traveling public. By providing information about dynamic roadway conditions on an in-vehicle device, the ATDM may improve driving safety and performance by allowing drivers to remain consistently aware of forthcoming traffic conditions and roadway requirements; even when external signage is inaccessible. This study represents an initial investigation of an emulated in-vehicle ATDM to provide developers with design guidance and ensure that unintended consequences, such as distraction, do not undermine the potential benefits.Twenty younger and 20 older participants, accompanied by a member of the research team, experienced the following ATDM features on an in-vehicle device (IVD) mounted to the dashboard: (1) dynamic speed limits, (2) dynamic lane use/shoulder control, (3) High Occupancy Vehicle (HOV) restrictions, and (4) roadway information from variable message signs. The IVD was equipped with auditory and visual alerts notifying the driver when relevant visual information was updated. Research questions addressed distraction and driver behavior associated with use of the system. Qualitative and quantitative participant data was acquired from the instrumented vehicle, various questionnaires, and researcher observation.Several key findings were uncovered: (1) The IVD, as tested, did not warrant classification as a source of distraction according to the NHTSA guidelines; v2) There was a significant difference in eye-glance durations to the IVD when comparing the VMS alerts to both the speed limit and lane management alerts; and (3) The speed limit alert motivated participants to alter their speed (per survey results and participant speed data).     

Using the UTAUT2 model to explain public acceptance of conditionally automated (L3) cars: A questionnaire study among 9,118 car drivers from eight European countries

We investigated public acceptance of conditionally automated (SAE Level 3) passenger cars using a questionnaire study among 9,118 car-drivers in eight European countries, as part of the European L3Pilot project. 71.06% of respondents considered conditionally automated cars easy to use while 28.03% of respondents planned to buy a conditionally automated car once it is available. 41.85% of respondents would like to use the time in the conditionally automated car for secondary activities. Among these 41.85%, respondents plan to talk to fellow travellers (44.76%), surf the internet, watch videos or TV shows (44%), observe the landscape (41.70%), and work (17.06%). The UTAUT2 (Unified Theory of Acceptance and Use of Technology) was applied to investigate the effects of performance and effort expectancy, social influence, facilitating conditions, and hedonic motivation on the behavioural intention to use conditionally automated cars. Structural equation analysis revealed that the UTAUT2 can be applied to conditional automation, with hedonic motivation, social influence, and performance expectancy influencing the behavioural intention to buy and use a conditionally automated car. The present study also found positive effects of facilitating conditions on effort expectancy and hedonic motivation. Social influence was a positive predictor of hedonic motivation, facilitating conditions, and performance expectancy. Age, gender and experience with advanced driver assistance systems had significant, yet small (<0.10), effects on behavioural intention. The implications of these results on the policy and best practices to enable large-scale implementation of conditionally automated cars on public roads are discussed.     

The Harvard Pigeon Lab under Herrnstein

The history of the Harvard Pigeon Lab is a history of two periods of remarkable productivity, the first under Skinner's leadership and the second under Herrnstein's. In each period, graduate students flocked to the leader and then began stimulating one another. Chance favored Herrnstein's leadership, too, because an unusually large number of graduate students were admitted in the fall of 1962. In each period, productivity declined as the leader lost interest in the laboratory and withdrew. Directly and indirectly, the laboratory finally died as a result of the cognitive "revolution." Skinner and his students saw the possibility of a natural science of behavior and set about establishing that science based on concepts such as response rate, stimulus control, and schedules of reinforcement. Herrnstein and his students saw that the science could be quantitative and set about making it so, with relative response rate, the matching law, and the psychophysics of choice (analogous to S. S. Stevens' psychophysics). The history might provide a golden research opportunity for someone interested in the impact of such self-organizing research groups on the progress of science.     

What did mummy say? Dyadic interactions between young "hard to manage" children and their mothers

Thirty preschoolers rated as hard to manage on Goodman's (R. Goodman, 1997) Strengths and Difficulties Questionnaire (SDQ), and a group of matched control children were observed and recorded on audiotape at home, interacting with their mothers (Time 1). At the 18-month follow-up home visits (Time 2), the children and mothers were filmed across 4 observation settings. Mother–child interactions were rated on affect, control, responsiveness and connectedness of communication. At Time 1, mothers of the hard to manage group used more negative control and engaged in fewer connected conversations than did mothers in the control group. At Time 2, mothers of the hard to manage group displayed higher levels of negative control and lower levels of positive control. These results are discussed in terms of the importance of examining connected communication and different observation contexts when examining dyadic mother–child interactions.     

MMPI-2 subgroups in a sample of chronic pain patients

MMPI-2 scores of 307 female and 161 male chronic pain patients were analyzed by gender using a multivariate clustering method. Two subgroups were found for both sexes replicating previous results. The major subgroup corresponded to the classical "Conversion V" and the minor corresponded to the "Generally elevated" profile. The results also indicated a satisfactory internal consistency and a high discriminant validity of the Swedish version of the MMPI-2.     

Predictive Genetic Testing for Hereditary Breast and Ovarian Cancer: Psychological Distress and Illness Representations 1 Year Following Disclosure

This prospective study evaluates emotional functioning and illness representations in 68 unaffected women (34 carriers/34 noncarriers) 1 year after predictive testing for BRCA1/2 mutations when offered within a multidisciplinary approach. Carriers had higher subjective risk perception of breast cancer than noncarriers. Carriers who did not have prophylactic oophorectomy had the highest risk perception of ovarian cancer. No differences were found between carriers and noncarriers regarding perceived seriousness and perceived control of breast and ovarian cancer. Mean levels of distress were within normal ranges. Only few women showed an overall pattern of clinically elevated distress. Cancer-specific distress and state-anxiety significantly decreased in noncarriers from pre- to posttest while general distress remained about the same. There were no significant changes in distress in the group of carriers except for ovarian cancer distress which significantly decreased from pre- to posttest. Our study did not reveal adverse effects of predictive testing when offered in the context of a multidisciplinary approach.     

Steps and pips in the history of the cumulative recorder

From its inception in the 1930s until very recent times, the cumulative recorder was the most widely used measurement instrument in the experimental analysis of behavior. It was an essential instrument in the discovery and analysis of schedules of reinforcement, providing the first real-time analysis of operant response rates and patterns. This review traces the evolution of the cumulative recorder from Skinner's early modified kymographs through various models developed by Skinner and his colleagues to its perfection in the 1950s, and then into the 1960s when it proliferated as different scientific instrument companies began marketing their own models of the cumulative recorder. With the rise of digital computers, the demise of the cumulative recorder as a scientific instrument was inevitable; however, the value of the cumulative record as a monitoring device to assess schedule control of behavior continues. The cumulative recorder remains, along with the operant conditioning chamber, an icon of Skinner's approach to psychology.