试论社会人群中医学信息的不对称性

简述了社会人群中产生的医学信息不对称性的根源、特点和社会效应,以及医务人员应如何正确对待这个问题.     

Correlation between inspection time and psychometric abilities: A personal interpretation

More than 25 years of research suggests that the measure inspection time (IT) does capture low-level aspects of cognitive functioning that contribute to human intelligence. However, recent evidence does not support earlier claims that IT estimates the speed of a single mechanism like “sampling input” or “apprehension.” Rather, together with other tasks that employ pattern backward masking to limit the duration for which information is available for processing, IT is probably sensitive both to focused attentional capacities to detect organization and change under severe time constraints and to decision processes, ongoing beyond mask onset, that monitor responding. Among normal young adults, IT is correlated with the broad psychometric factor Gs (“speediness”). This mediates correlation with general intelligence. In this group, IT is not correlated with Gf. However, whether this outcome generalizes to samples of persons with an intellectual disability, to young children, or to elderly persons is not yet known. Psychological processes underpinning IT are currently only speculatively defined, but it should prove possible to unravel these by experimentation. To this end, backward masking procedures are arguably more theoretically tractable than reaction time tasks because they reduce the impact of higher-level cognitive strategies on performance. On this basis, IT may hold promise as a means for developing partial explanations for intelligence in psychological terms. However, whether this is realized depends on identifying the psychological functions that support IT.     

Test theory without an answer key

A general model is presented for homogeneous, dichotomous items when the answer key is not known a priori. The model is structurally related to the two-class latent structure model with the roles of respondents and items interchanged. For very small sets of respondents, iterative maximum likelihood estimates of the parameters can be obtained by existing methods. For other situations, new estimation methods are developed and assessed with Monte Carlo data. The answer key can be accurately reconstructed with relatively small sets of respondents. The model is useful when a researcher wants to study objectively the knowledge possessed by members of a culturally coherent group that the researcher is not a member of.This research was supported by NSF Grant No. SES-8320173 to the authors. We gratefully acknowledge comments and suggestions from John Boyd, Tarow Indow, and Kathy Maher as well as the editor and several anonymous referees.     

超重女性对食物信息加工的注意偏向和记忆偏向

采用与食物图片相关的点探测任务和学习—再认范式考察超重女性对不同热量食物信息的注意偏向和记忆偏向。结果发现：(1) 超重女性对高热量食物信息存在注意警觉—注意脱离困难模式,对低热量食物信息仅表现为注意回避模式。(2) 超重组女性对高热量食物信息的再认正确率显著高于正常体重组,而对低热量食物信息的再认成绩组间差异不显著。研究结果证实了超重女性对高热量食物信息投入更多的认知资源,存在注意偏向和记忆偏向。     

文本阅读过程中信息的协调性整合

采用移动窗口阅读技术探讨文本阅读中信息的协调性整合问题。被试为华南师范大学本科生120名。实验材料按照主 人公特征与其目标句行为的关系总体上分为一致与恢复一致两个版本,每个版本都有两个目标句,出现在不同位置。实验1主 要探讨阅读过程中背景信息的激活与协调性整合的性质与特点,实验2主要探讨阅读过程工作记忆中前后信息的协调性整合 问题。采用相关样本t检验分别对两个目标句的阅读时间进行统计分析,结果发现,无论是通过共振激活的背景信息,还是保留 在工作记忆的文本信息,如果与新进入的文本信息有局部的不协调,那么就会产生协调性整合,整合的结果不仅维持了文本的连 贯,而且将相关的信息建构成整体的信息块     

Concise formulas for the standard errors of component loading estimates

Concise formulas for the asymptotic standard errors of component loading estimates were derived. The formulas cover the cases of principal component analysis for unstandardized and standardized variables with orthogonal and oblique rotations. The formulas can be used under any distributions for observed variables as long as the asymptotic covariance matrix for sample covariances/correlations is available. The estimated standard errors in numerical examples were shown to be equivalent to those by the methods using information matrices.The author is indebted to anonymous reviewers for the corrections and suggestions on this study, which have led to improvements of earlier versions of this article.     

The use of genetic test information in insurance: The argument from indistinguishability reconsidered

In the bioethical literature, discrimination in insurance on the basis of genetic risk factors detected by genetic testing has been defended and opposed on various ethical grounds. One important argument in favour of the practice is offered by those who believe that it is not possible to distinguish between genetic and non-genetic information, at least not for practical policy purposes such as insurance decision-making. According to the argument from indistinguishability, the use of genetic test information for insurance purposes should be permitted, because genetic test information is no different from non-genetic medical information in any relevant respect, therefore it would be inconsistent to prohibit the former whilst permitting the latter. This paper discusses and defends this argument and suggests a new, more tenable foundation.     

Doctor's Expertise and Managing Discrepant Information from Other Sources in Genetic Counseling: A Conversation Analytic Perspective

The study examines a recurrent interactional pattern in genetic counseling. It describes clinical geneticists' responses in situations in which clients have presented information from other sources that is potentially discrepant with information given by the doctor. The data consists of 12 video-recorded sessions of genetic counseling in Finland, and the method is conversation analysis. There are two primary ways the doctors respond: either they accept the client's information as such, but show that it is not discrepant with the doctor's information, or they reject the client's information. In the latter case they mitigate the ‘wrongness’ of the client's information. The clinical geneticists seem to be working with a dilemma: they need to find a balance between ensuring correct understanding of the information and showing respect for the expertise of others. A particularly complex case is also analyzed and reflected on.     

The Nature and Significance of Behavioural Genetic Information

In light of the human genome project, establishing the genetic aetiology of complex human diseases has become a research priority within Western medicine. However, in addition to the identification of disease genes, numerous research projects are also being undertaken to identify genes contributing to the development of human behavioural characteristics, such as cognitive ability and criminal tendency. The permissibility of this research is obviously controversial: will society benefit from this research, or will it adversely affect our conceptions of ourselves and each other? When assessing the permissibility of this research, it is important to consider the nature and deterministic significance of behavioural genetic information. Whilst todate there has been much discussion and debate about the properties of genetic information per se and genetic determinism, this has not been applied to behavioural genetic research and its ethical implications. Therefore, this paper elucidates how behavioural genetic information can be distinguished from other types of genetic and non-genetic information and also synthesises the determinative significance of genetic factors for the development of human behavioural traits. Undertaking this analysis enables the ethical issues raised by this research to be debated in an appropriate context and indicates that separate policy considerations are warranted.

     

Emotional avoidance: an experimental test of individual differences and response suppression using biological challenge

The present study examined the affective consequences of response inhibition during a state of anxiety-related physical stress. Forty-eight non-clinical participants were selected on the basis of pre-experimental differences in emotional avoidance (high versus low) and subjected to four inhalations of 20% carbon dioxide-enriched air. Half of the participants were instructed to inhibit the challenge-induced aversive emotional state, whereas the other half was instructed to simply observe their emotional response. Participants high in emotional avoidance compared to those low in emotional avoidance responded with greater levels of anxiety and affective distress but not physiological arousal. Individuals high in emotional avoidance also reported greater levels of anxiety relative to the low emotional avoidance group when suppressing compared to observing bodily sensations. These findings are discussed in terms of the significance of emotional avoidance processes during physical stress, with implications for better understanding the nature of panic disorder.